| 05 May 2008 | First Round | Rawtenstall v East Lancashire | The Worswick Memorial Ground, Rawtenstall | Results |
| 18 May 2008 | First Round | Fulwood and Broughton v Denton St Lawrence | Highfield, Broughton | Results |
| 15 Jun 2008 | Second Round | Burscough v Denton St Lawrence | School Lane, Burscough | Results |
| 11 May 2008 | First Round | Sutton v Denton West | New Street, Sutton | Results |
| 11 May 2008 | First Round | Walshaw v Clifton | Sycamore Road, Tottington | Results |
| 11 May 2008 | First Round | Stayley v Friarmere | Oxford Street, Millbrook | Results |
| 11 May 2008 | First Round | Egerton v Baxenden | Blackburn Road, Egerton | Results |
| 11 May 2008 | First Round | Penwortham v Walkden | Middleforth Green, Penwortham | Results |
| 11 May 2008 | First Round | Swinton Moorside v Greenmount | Moorside Park, Swinton | Results |
| 11 May 2008 | First Round | Darwen v Colwyn Bay | The Brookhouse Aerospace Birch Hall Cricket Ground, Darwen | Results |
| 11 May 2008 | First Round | Castletown v Padiham | King William's College, Castletown | Results |
| 25 May 2008 | First Round | Edgworth v Winton | Barlow Memorial Ground, Edgworth | Results |
| 11 May 2008 | First Round | Heywood v Norley Hall | The Crimble Ground, Heywood | Results |
| 11 May 2008 | First Round | Tonge v Cheetham Hill | Castle Hill, Bolton | Results |
| 11 May 2008 | First Round | Stretford v Norden | The Boundary, Stretford | Results |
| 11 May 2008 | First Round | Great Eccleston v Kashmir | Hall Lane, Great Eccleston | Results |
| 11 May 2008 | First Round | Burscough v Wythenshawe | School Lane, Burscough | Results |
| 11 May 2008 | First Round | New Brighton v Rainford | Rake Lane, Wallasey | Results |
| 11 May 2008 | First Round | Hollinwood v Northern | Lime Lane, Hollinwood | Results |
| 11 May 2008 | First Round | Vernon Carus v Morecambe | Factory Lane, Penwortham | Results |
| 11 May 2008 | First Round | Preston v Unsworth | West Cliff, Preston | Results |
| 20 Apr 2008 | First Round | Great Harwood v Prestwich | Evolve Document Solutions Cliffe Park, Great Harwood | Results |
| 05 May 2008 | First Round | Whalley v Glossop | Station Road, Whalley | Results |
| 11 May 2008 | First Round | Standish v Farnworth Social Circle | Green Lane, Standish | Results |
| 11 May 2008 | First Round | Little Hulton v South West Manchester | The Old Vicarage, Little Hulton | Results |
| 11 May 2008 | First Round | Rochdale v Bootle | Redbrook, Rochdale | Results |
| 11 May 2008 | First Round | BAC-EE Preston v Skelmersdale | Riverside, Preston | Results |
| 11 May 2008 | First Round | Bamford Fieldhouse v Lytham | Hollin Lane, Bamford | Results |
| 11 May 2008 | First Round | Kendal v Blackburn Northern | Shap Road, Kendal | Results |
| 11 May 2008 | First Round | Shaw v Astley Bridge | Holebottom Clough, Shaw | Results |
| 15 Jun 2008 | Second Round | Walshaw v Denton West | Sycamore Road, Tottington | Results |
| 15 Jun 2008 | Second Round | Baxenden v Stayley | Back Lane, Baxenden | Results |
| 15 Jun 2008 | Second Round | Greenmount v Walkden | Brandlesholme Road, Greenmount | Results |
| 15 Jun 2008 | Second Round | Colwyn Bay v Ormskirk | Penrhyn Avenue, Rhos-on-Sea, Colwyn Bay | Results |
| 07 Jun 2008 | Second Round | Winton v Padiham | Alder Forest Avenue, Winton | Results |
| 31 May 2008 | Second Round | Tonge v Heywood | Castle Hill, Bolton | Results |
| 15 Jun 2008 | Second Round | Kashmir v Stretford | Kashmir Cricket Club Ground, Oldham | Results |
| 15 Jun 2008 | Second Round | Hollinwood v New Brighton | Lime Lane, Hollinwood | Results |
| 15 Jun 2008 | Second Round | Morecambe v Spring View | Woodhill Lane, Morecambe | Results |
| 15 Jun 2008 | Second Round | Prestwich v Preston | The Heys, Prestwich | Results |
| 06 Jun 2008 | Second Round | Farnworth Social Circle v Whalley | Piggott Park, Farnworth | Results |
| 01 Jun 2008 | Second Round | Bootle v Little Hulton | Wadham Road, Bootle | Results |
| 15 Jun 2008 | Second Round | Lytham v BAC-EE Preston | Church Road, Lytham St Annes | Results |
| 15 Jun 2008 | Second Round | St Annes v Kendal | Vernon Road, St Annes | Results |
| 15 Jun 2008 | Second Round | East Lancashire v Astley Bridge | Alexandra Meadows, Blackburn | Results |
| 06 Jul 2008 | Third Round | Denton West v Stayley | Windsor Park, Denton | Results |
| 22 Jun 2008 | Third Round | Walkden v Ormskirk | The Oval, Walkden | Results |
| 29 Jun 2008 | Third Round | Winton v Heywood | Alder Forest Avenue, Winton | Results |
| 06 Jul 2008 | Third Round | Stretford v Burscough | The Boundary, Stretford | Results |
| 06 Jul 2008 | Third Round | New Brighton v Morecambe | Rake Lane, Wallasey | Results |
| 30 Jun 2008 | Third Round | Prestwich v Farnworth Social Circle | The Heys, Prestwich | Results |
| 30 Jun 2008 | Third Round | Bootle v BAC-EE Preston | Wadham Road, Bootle | Results |
| 06 Jul 2008 | Third Round | Kendal v Astley Bridge | Shap Road, Kendal | Results |
| 27 Jul 2008 | Quarter-Final | Walkden v Denton West | The Oval, Walkden | Results |
| 27 Jul 2008 | Quarter-Final | Stretford v Winton | The Boundary, Stretford | Results |
| 27 Jul 2008 | Quarter-Final | Farnworth Social Circle v New Brighton | Piggott Park, Farnworth | Results |
| 13 Jul 2008 | Quarter-Final | Astley Bridge v Bootle | Sharples Park, Astley Bridge | Results |
| 10 Aug 2008 | Semi-Final | Walkden v Winton | The Oval, Walkden | Results |
| 10 Aug 2008 | Semi-Final | Farnworth Social Circle v Bootle | Piggott Park, Farnworth | Results |
| 14 Sep 2008 | Final | Farnworth Social Circle v Walkden | Stanley Park, Blackpool | Results |
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