| 09 May 1981 | Group B | Derbyshire v Yorkshire | Racecourse Ground, Derby | Results |
| 09 May 1981 | Group C | Glamorgan v Essex | St Helen's, Swansea | Results |
| 09 May 1981 | Group B | Lancashire v Warwickshire | Emirates Old Trafford, Manchester | Results |
| 09 May 1981 | Group A | Leicestershire v Gloucestershire | Uptonsteel County Ground, Leicester | Results |
| 09 May 1981 | Group D | Middlesex v Hampshire | Lord's Cricket Ground, St John's Wood | Results |
| 09 May 1981 | Group A | Northamptonshire v Nottinghamshire | County Ground, Northampton | Results |
| 11 May 1981 | Group C | Kent v Combined Universities | Spitfire Ground, St Lawrence, Canterbury | Results |
| 11 May 1981 | Group D | Sussex v Surrey | New County Ground, Hove | Results |
| 13 May 1981 | Group D | Hampshire v Minor Counties | County Ground, Southampton | Results |
| 16 May 1981 | Group C | Combined Universities v Glamorgan | The University Parks, Oxford | Results |
| 16 May 1981 | Group C | Essex v Somerset | The Cloud County Ground, Chelmsford | Results |
| 16 May 1981 | Group A | Gloucestershire v Northamptonshire | Seat Unique Stadium, Bristol | Results |
| 16 May 1981 | Group D | Hampshire v Surrey | Dean Park, Bournemouth | Results |
| 16 May 1981 | Group D | Minor Counties v Middlesex | Chalvey Road, Slough | Results |
| 16 May 1981 | Group A | Nottinghamshire v Worcestershire | Trent Bridge, Nottingham | Results |
| 16 May 1981 | Group B | Scotland v Lancashire | Titwood, Glasgow | Results |
| 16 May 1981 | Group B | Warwickshire v Derbyshire | Edgbaston, Birmingham | Results |
| 19 May 1981 | Group C | Combined Universities v Somerset | FP Fenner's Ground, Cambridge | Results |
| 19 May 1981 | Group B | Derbyshire v Scotland | Racecourse Ground, Derby | Results |
| 19 May 1981 | Group C | Glamorgan v Kent | Sophia Gardens, Cardiff | Results |
| 19 May 1981 | Group D | Middlesex v Sussex | Lord's Cricket Ground, St John's Wood | Results |
| 19 May 1981 | Group A | Northamptonshire v Leicestershire | County Ground, Northampton | Results |
| 19 May 1981 | Group B | Warwickshire v Yorkshire | Edgbaston, Birmingham | Results |
| 19 May 1981 | Group A | Worcestershire v Gloucestershire | Visit Worcestershire New Road, Worcester | Results |
| 21 May 1981 | Group C | Essex v Combined Universities | The Cloud County Ground, Chelmsford | Results |
| 21 May 1981 | Group A | Gloucestershire v Nottinghamshire | Winget Sports Ground, Gloucester | Results |
| 21 May 1981 | Group B | Lancashire v Derbyshire | Emirates Old Trafford, Manchester | Results |
| 21 May 1981 | Group A | Leicestershire v Worcestershire | Uptonsteel County Ground, Leicester | Results |
| 21 May 1981 | Group D | Minor Counties v Sussex | Chalvey Road, Slough | Results |
| 21 May 1981 | Group C | Somerset v Kent | The Cooper Associates County Ground, Taunton | Results |
| 21 May 1981 | Group D | Surrey v Middlesex | The Kia Oval, Kennington | Results |
| 21 May 1981 | Group B | Yorkshire v Scotland | Park Avenue Cricket Ground, Bradford | Results |
| 30 May 1981 | Group C | Kent v Essex | Hesketh Park, Dartford | Results |
| 30 May 1981 | Group A | Nottinghamshire v Leicestershire | Trent Bridge, Nottingham | Results |
| 30 May 1981 | Group B | Scotland v Warwickshire | Titwood, Glasgow | Results |
| 30 May 1981 | Group C | Somerset v Glamorgan | The Cooper Associates County Ground, Taunton | Results |
| 30 May 1981 | Group D | Surrey v Minor Counties | The Kia Oval, Kennington | Results |
| 30 May 1981 | Group D | Sussex v Hampshire | New County Ground, Hove | Results |
| 30 May 1981 | Group A | Worcestershire v Northamptonshire | Visit Worcestershire New Road, Worcester | Results |
| 30 May 1981 | Group B | Yorkshire v Lancashire | Headingley, Leeds | Results |
| 24 Jun 1981 | Quarter-Final | Kent v Warwickshire | The Kia Oval, Kennington | Results |
| 24 Jun 1981 | Quarter-Final | Nottinghamshire v Surrey | Trent Bridge, Nottingham | Results |
| 24 Jun 1981 | Quarter-Final | Sussex v Leicestershire | New County Ground, Hove | Results |
| 24 Jun 1981 | Quarter-Final | Yorkshire v Somerset | Headingley, Leeds | Results |
| 08 Jul 1981 | Semi-Final | Somerset v Kent | The Cooper Associates County Ground, Taunton | Results |
| 08 Jul 1981 | Semi-Final | Surrey v Leicestershire | The Kia Oval, Kennington | Results |
| 25 Jul 1981 | Final | Somerset v Surrey | Lord's Cricket Ground, St John's Wood | Results |
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