| 24 Apr 2022 | Group 1 Preliminary Round | Hetton Lyons v Sessay | Lilywhite Terrace, Hetton-le-Hole | Results |
| 01 May 2022 | Group 1 Preliminary Round | Wakefield Thornes v Harrogate | Field Lane, Wakefield | Results |
| 01 May 2022 | Group 1 Preliminary Round | Sheriff Hutton Bridge v South Kirkby | Moor Farm, Strensall | Results |
| 01 May 2022 | Group 1 Preliminary Round | Hartlepool v Driffield Town | Park Drive, Hartlepool | Results |
| 15 May 2022 | Group 1 First Round | Richmondshire v Hetton Lyons | Hugill Road, Richmond | Results |
| 15 May 2022 | Group 1 First Round | Woodlands v Wakefield Thornes | Albert Terrace, Oakenshaw | Results |
| 15 May 2022 | Group 1 First Round | Appleby Frodingham v South Kirkby | Brumby Hall, Scunthorpe | Results |
| 15 May 2022 | Group 1 First Round | Chester-le-Street v Hartlepool | Ropery Lane, Chester-le-Street | Results |
| 29 May 2022 | Group 1 Second Round | Richmondshire v Woodlands | Hugill Road, Richmond | Results |
| 29 May 2022 | Group 1 Second Round | Appleby Frodingham v Hartlepool | Brumby Hall, Scunthorpe | Results |
| 19 Jun 2022 | Group 1 Third Round | Woodlands v Appleby Frodingham | Albert Terrace, Oakenshaw | Results |
| 01 May 2022 | Group 2 Preliminary Round | Clifton Alliance v Consett | Clifton Hospital Ground, York | Results |
| 01 May 2022 | Group 2 Preliminary Round | Treeton v Stockton | Washfield Lane, Treeton | Results |
| 01 May 2022 | Group 2 Preliminary Round | Benwell Hill v York | Denton Bank, Benwell Hill | Results |
| 15 May 2022 | Group 2 First Round | South Northumberland v Clifton Alliance | Roseworth Terrace, Gosforth | Results |
| 15 May 2022 | Group 2 First Round | Scarborough v Stockton | Queens, Scarborough | Results |
| 15 May 2022 | Group 2 First Round | Castleford v York | Savile Park, Castleford | Results |
| 15 May 2022 | Group 2 First Round | Barnard Castle v Woodhouse Grange | Vere Road, Barnard Castle | Results |
| 29 May 2022 | Group 2 Second Round | South Northumberland v Stockton | Roseworth Terrace, Gosforth | Results |
| 29 May 2022 | Group 2 Second Round | York v Barnard Castle | Clifton Park, York | Results |
| 19 Jun 2022 | Group 2 Third Round | South Northumberland v York | Roseworth Terrace, Gosforth | Results |
| 01 May 2022 | Group 3 Preliminary Round | Spondon v Attenborough | Locko Road, Spondon | Results |
| 01 May 2022 | Group 3 Preliminary Round | Papplewick and Linby v Doncaster Town | Hall Lane, Papplewick | Results |
| 01 May 2022 | Group 3 Preliminary Round | Langtons v Tutbury | Langtons Cricket Club Ground, East Langton | Results |
| 01 May 2022 | Group 3 Preliminary Round | Alvaston and Boulton v Clifton Village | Raynesway, Alvaston | Results |
| 15 May 2022 | Group 3 First Round | Kibworth v Spondon | Kibworth Cricket Club New Ground, Kibworth | Results |
| 15 May 2022 | Group 3 First Round | Ockbrook and Borrowash v Doncaster Town | Victoria Avenue, Ockbrook | Results |
| 15 May 2022 | Group 3 First Round | Kimberley Institute v Langtons | Private Ground, Kimberley | Results |
| 15 May 2022 | Group 3 First Round | Sheffield Collegiate v Clifton Village | Abbeydale Park, Sheffield | Results |
| 29 May 2022 | Group 3 Second Round | Kimberley Institute v Clifton Village | Private Ground, Kimberley | Results |
| 29 May 2022 | Group 3 Second Round | Kibworth v Ockbrook and Borrowash | Kibworth Cricket Club New Ground, Kibworth | Results |
| 19 Jun 2022 | Group 3 Third Round | Kibworth v Kimberley Institute | Kibworth Cricket Club New Ground, Kibworth | Results |
| 01 May 2022 | Group 4 Preliminary Round | Cuckney v Newtown Linford | Langwith Road, Cuckney | Results |
| 01 May 2022 | Group 4 Preliminary Round | Denby v Tickhill | The Copper Yard, Denby Village | Results |
| 08 May 2022 | Group 4 Preliminary Round | Grantham v Wollaton | Gorse Lane, Grantham | Results |
| 15 May 2022 | Group 4 First Round | Sandiacre Town v Cuckney | Longmoor Lane, Sandiacre | Results |
| 15 May 2022 | Group 4 First Round | Cavaliers and Carrington v Denby | Carrington Sports Ground, Nottingham | Results |
| 15 May 2022 | Group 4 First Round | Ticknall v Grantham | The Grange, Ticknall | Results |
| 15 May 2022 | Group 4 First Round | Loughborough Town v Radcliffe-on-Trent | Park Road, Loughborough | Results |
| 29 May 2022 | Group 4 Second Round | Sandiacre Town v Denby | Longmoor Lane, Sandiacre | Results |
| 12 Jun 2022 | Group 4 Second Round | Grantham v Radcliffe-on-Trent | Gorse Lane, Grantham | Results |
| 19 Jun 2022 | Group 4 Third Round | Sandiacre Town v Grantham | Longmoor Lane, Sandiacre | Results |
| 01 May 2022 | Group 5 Preliminary Round | Wigan v Dalton | Bull Hey, Wigan | Results |
| 24 Apr 2022 | Group 5 Preliminary Round | Lancaster v Furness | Lune Road, Lancaster | Results |
| 01 May 2022 | Group 5 Preliminary Round | Formby v Ribblesdale Wanderers | Cricket Path, Formby | Results |
| 01 May 2022 | Group 5 Preliminary Round | Farnworth v Southport and Birkdale | Bridgeman Park, Farnworth | Results |
| 24 Apr 2022 | Group 5 Preliminary Round | Ormskirk v St Annes | Brook Lane, Ormskirk | Results |
| 15 May 2022 | Group 5 First Round | Walkden v Dalton | The Oval, Walkden | Results |
| 15 May 2022 | Group 5 First Round | Furness v Formby | Furness Park, Barrow-in-Furness | Results |
| 15 May 2022 | Group 5 First Round | Northern v Farnworth | Moor Park, Great Crosby | Results |
| 15 May 2022 | Group 5 First Round | Prestwich v Ormskirk | The Heys, Prestwich | Results |
| 29 May 2022 | Group 5 Second Round | Walkden v Furness | The Oval, Walkden | Results |
| 29 May 2022 | Group 5 Second Round | Northern v Ormskirk | Moor Park, Great Crosby | Results |
| 19 Jun 2022 | Group 5 Third Round | Furness v Northern | Furness Park, Barrow-in-Furness | Results |
| 01 May 2022 | Group 6 Preliminary Round | Rainhill v Chorley | Rainhill Recreation Ground, Rainhill | Results |
| 01 May 2022 | Group 6 Preliminary Round | Longridge v New Brighton | George Newsham Memorial Cricket Ground, Longridge | Results |
| 01 May 2022 | Group 6 Preliminary Round | Leigh v Workington | Beech Walk, Leigh | Results |
| 24 Apr 2022 | Group 6 Preliminary Round | Netherfield v Whitehaven | Parkside Road, Kendal | Results |
| 01 May 2022 | Group 6 Preliminary Round | Westhoughton v Highfield | The Tyldesleys, Westhoughton | Results |
| 01 May 2022 | Group 6 Preliminary Round | Denton West v Birkenhead Park | Windsor Park, Denton | Results |
| 15 May 2022 | Group 6 First Round | Blackpool v Chorley | Stanley Park, Blackpool | Results |
| 15 May 2022 | Group 6 First Round | Wallasey v Longridge | The Kevin McCullagh Oval, Wallasey | Results |
| 15 May 2022 | Group 6 First Round | Leigh v Netherfield | Beech Walk, Leigh | Results |
| 15 May 2022 | Group 6 First Round | Westhoughton v Denton West | The Tyldesleys, Westhoughton | Results |
| 29 May 2022 | Group 6 Second Round | Blackpool v Wallasey | Stanley Park, Blackpool | Results |
| 29 May 2022 | Group 6 Second Round | Leigh v Westhoughton | Beech Walk, Leigh | Results |
| 19 Jun 2022 | Group 6 Third Round | Wallasey v Leigh | The Kevin McCullagh Oval, Wallasey | Results |
| 01 May 2022 | Group 7 Preliminary Round | J and G Meakin v Oxton | Dave Kettle Memorial Ground, Hanley | Results |
| 01 May 2022 | Group 7 Preliminary Round | Barnards Green v Timperley | North End Lane, Malvern | Results |
| 15 May 2022 | Group 7 First Round | Barnt Green v J and G Meakin | Cherry Hill Road, Barnt Green | Results |
| 15 May 2022 | Group 7 First Round | Nantwich v Timperley | Whitehouse Lane, Nantwich | Results |
| 15 May 2022 | Group 7 First Round | Leamington v Longton | Arlington Avenue, Leamington Spa | Results |
| 15 May 2022 | Group 7 First Round | St Asaph v Shrewsbury | Elwy Grove Park, St Asaph | Results |
| 12 Jun 2022 | Group 7 Second Round | Barnt Green v Nantwich | Cherry Hill Road, Barnt Green | Results |
| 29 May 2022 | Group 7 Second Round | Longton v St Asaph | Trentham Road, Stoke-on-Trent | Results |
| 19 Jun 2022 | Group 7 Third Round | Nantwich v St Asaph | Whitehouse Lane, Nantwich | Results |
| 01 May 2022 | Group 8 Preliminary Round | Oulton Park v Stone | Pinfold Lane, Little Budworth | Results |
| 08 May 2022 | Group 8 Preliminary Round | Wolverhampton v Elworth | Danescourt, Wolverhampton | Results |
| 15 May 2022 | Group 8 Preliminary Round | Chester Boughton Hall v Moseley | Boughton Hall Avenue, Chester | Results |
| 01 May 2022 | Group 8 Preliminary Round | Walsall v Widnes | Gorway, Walsall | Results |
| 15 May 2022 | Group 8 First Round | Kidderminster v Stone | Chester Road North, Kidderminster | Results |
| 15 May 2022 | Group 8 First Round | Porthill Park v Elworth | Knutton Road, Wolstanton | Results |
| 15 May 2022 | Group 8 First Round | Didsbury v Widnes | Wilmslow Road, Didsbury | Results |
| 29 May 2022 | Group 8 Second Round | Knowle and Dorridge v Chester Boughton Hall | Station Road, Dorridge | Results |
| 29 May 2022 | Group 8 Second Round | Stone v Porthill Park | Lichfield Road, Stone | Results |
| 12 Jun 2022 | Group 8 Third Round | Knowle and Dorridge v Didsbury | Station Road, Dorridge | Results |
| 01 May 2022 | Group 9 Preliminary Round | Bovey Tracey v Corsham | The Recreation Ground, Bovey Tracey | Results |
| 01 May 2022 | Group 9 Preliminary Round | Bedminster v Neath | The Clanage, Bower Ashton | Results |
| 08 May 2022 | Group 9 Preliminary Round | Bashley (Rydal) v Ferndown Wayfarers | Bashley Road, Bashley | Results |
| 15 May 2022 | Group 9 First Round | Bath v Bovey Tracey | North Parade, Bath | Results |
| 15 May 2022 | Group 9 First Round | St Fagans v Bedminster | Croft-y-Genau Road, St Fagans | Results |
| 15 May 2022 | Group 9 First Round | South Wilts v Lansdown | Bemerton Sports Ground, Salisbury | Results |
| 15 May 2022 | Group 9 First Round | Potterne v Bashley (Rydal) | The Grove, Potterne | Results |
| 29 May 2022 | Group 9 Second Round | Bath v St Fagans | North Parade, Bath | Results |
| 29 May 2022 | Group 9 Second Round | South Wilts v Potterne | Bemerton Sports Ground, Salisbury | Results |
| 19 Jun 2022 | Group 9 Third Round | Bath v Potterne | North Parade, Bath | Results |
| 17 Apr 2022 | Group 10 Preliminary Round | Taunton Deane v Newport | The Convent Field, Taunton | Results |
| 02 May 2022 | Group 10 Preliminary Round | Bridgwater v Pentyrch | The Parks, Bridgwater | Results |
| 15 May 2022 | Group 10 First Round | Penzance v Plymouth | St Clare Ground, Penzance | Results |
| 22 May 2022 | Group 10 First Round | Clevedon v Swansea | Dial Hill, Clevedon | Results |
| 15 May 2022 | Group 10 First Round | Sandford v Newport | Creedy Park, Sandford | Results |
| 22 May 2022 | Group 10 First Round | St Cross Symondians v Bridgwater | Green Jackets Ground, Winchester | Results |
| 05 Jun 2022 | Group 10 Second Round | Sandford v Bridgwater | Creedy Park, Sandford | Results |
| 29 May 2022 | Group 10 Second Round | Penzance v Swansea | St Clare Ground, Penzance | Results |
| 26 Jun 2022 | Group 10 Third Round | Penzance v Bridgwater | St Clare Ground, Penzance | Results |
| 01 May 2022 | Group 11 Preliminary Round | Havant v Littlehampton, Clapham and Patching | Havant Park, Havant | Results |
| 01 May 2022 | Group 11 Preliminary Round | Stanmore v Berkhamsted | Stanmore Common, Stanmore | Results |
| 01 May 2022 | Group 11 Preliminary Round | Hook and Newnham Basics v Shinfield | King George V Playing Field, Hook | Results |
| 22 May 2022 | Group 11 First Round | High Wycombe v Havant | London Road, High Wycombe | Results |
| 15 May 2022 | Group 11 First Round | Teddington v Aston Rowant | Teddington Cricket Club Ground, Bushy Park, Teddington | Results |
| 22 May 2022 | Group 11 First Round | Weybridge v Stanmore | The Cricket Green, Weybridge | Results |
| 15 May 2022 | Group 11 First Round | Richmond v Hook and Newnham Basics | Old Deer Park, Richmond | Results |
| 29 May 2022 | Group 11 Second Round | High Wycombe v Aston Rowant | London Road, High Wycombe | Results |
| 29 May 2022 | Group 11 Second Round | Weybridge v Richmond | The Cricket Green, Weybridge | Results |
| 19 Jun 2022 | Group 11 Third Round | Aston Rowant v Richmond | The Butts Way, Kingston Blount | Results |
| 01 May 2022 | Group 12 Preliminary Round | Shepherds Bush v Malden Wanderers | Beechwood Grove, Shepherds Bush | Results |
| 01 May 2022 | Group 12 Preliminary Round | Datchet v Waterlooville | Wally Gage Memorial Ground, Datchet | Results |
| 01 May 2022 | Group 12 Preliminary Round | Normandy v Portsmouth | Hunts Hill Road, Normandy | Results |
| 15 May 2022 | Group 12 First Round | Sunbury v Shepherds Bush | Kenton Court Meadow, Sunbury-on-Thames | Results |
| 15 May 2022 | Group 12 First Round | Buckingham Town v Ealing | Bourton Road, Buckingham | Results |
| 15 May 2022 | Group 12 First Round | Brondesbury v Datchet | Harman Drive, Brondesbury | Results |
| 15 May 2022 | Group 12 First Round | Banbury v Normandy | White Post Road, Bodicote | Results |
| 29 May 2022 | Group 12 Second Round | Datchet v Banbury | Wally Gage Memorial Ground, Datchet | Results |
| 29 May 2022 | Group 12 Second Round | Sunbury v Buckingham Town | Kenton Court Meadow, Sunbury-on-Thames | Results |
| 19 Jun 2022 | Group 12 Third Round | Sunbury v Datchet | Kenton Court Meadow, Sunbury-on-Thames | Results |
| 01 May 2022 | Group 13 Preliminary Round | Hertford v Bedford Park | Balls Park, Hertford | Results |
| 01 May 2022 | Group 13 Preliminary Round | Swardeston v Bishop's Stortford | The Common, Swardeston | Results |
| 01 May 2022 | Group 13 Preliminary Round | Bourne v Horsford | Abbey Lawn, Bourne | Results |
| 01 May 2022 | Group 13 Preliminary Round | Great Witchingham v West Herts | Walcis Park, Great Witchingham | Results |
| 01 May 2022 | Group 13 Preliminary Round | Crouch End v Martians | The Calthorpe Ground, Crouch End | Results |
| 15 May 2022 | Group 13 First Round | Peterborough Town v Hertford | Bretton Gate, Peterborough | Results |
| 15 May 2022 | Group 13 First Round | Swardeston v Bourne | The Common, Swardeston | Results |
| 15 May 2022 | Group 13 First Round | Harpenden v West Herts | The Common, Harpenden | Results |
| 22 May 2022 | Group 13 First Round | Wanstead and Snaresbrook v Crouch End | Overton Drive, Wanstead | Results |
| 29 May 2022 | Group 13 Second Round | Harpenden v Wanstead and Snaresbrook | The Common, Harpenden | Results |
| 29 May 2022 | Group 13 Second Round | Peterborough Town v Swardeston | Bretton Gate, Peterborough | Results |
| 19 Jun 2022 | Group 13 Third Round | Peterborough Town v Wanstead and Snaresbrook | Bretton Gate, Peterborough | Results |
| 01 May 2022 | Group 14 Preliminary Round | North Middlesex v Saffron Walden | North Middlesex Cricket Club Ground, Crouch End | Results |
| 01 May 2022 | Group 14 Preliminary Round | Totteridge Millhillians v Sudbury | Totteridge Green, Totteridge | Results |
| 01 May 2022 | Group 14 Preliminary Round | Hadleigh and Thundersley v Winchmore Hill | John H Burrows Recreation Ground, Hadleigh | Results |
| 01 May 2022 | Group 14 Preliminary Round | Hornchurch v Finchley | Harrow Lodge Park, Hornchurch | Results |
| 01 May 2022 | Group 14 Preliminary Round | Brentwood v Harrow Town | Old County Ground, Brentwood | Results |
| 01 May 2022 | Group 14 Preliminary Round | Mildenhall v Waltham | Wamil Way, Mildenhall | Results |
| 22 May 2022 | Group 14 First Round | Chelmsford v North Middlesex | Chelmer Park, Chelmsford | Results |
| 22 May 2022 | Group 14 First Round | Totteridge Millhillians v Hadleigh and Thundersley | Totteridge Green, Totteridge | Results |
| 15 May 2022 | Group 14 First Round | Sawston and Babraham v Hornchurch | Spicer's Sports Ground, Sawston | Results |
| 22 May 2022 | Group 14 First Round | Brentwood v Mildenhall | Old County Ground, Brentwood | Results |
| 29 May 2022 | Group 14 Second Round | Sawston and Babraham v Brentwood | Spicer's Sports Ground, Sawston | Results |
| 29 May 2022 | Group 14 Second Round | North Middlesex v Hadleigh and Thundersley | North Middlesex Cricket Club Ground, Crouch End | Results |
| 19 Jun 2022 | Group 14 Third Round | North Middlesex v Brentwood | North Middlesex Cricket Club Ground, Crouch End | Results |
| 01 May 2022 | Group 15 Preliminary Round | Wimbledon v Beckenham | Church Road, Wimbledon | Results |
| 01 May 2022 | Group 15 Preliminary Round | Three Bridges v Bromley | Three Bridges Road, Three Bridges | Results |
| 01 May 2022 | Group 15 Preliminary Round | Blackheath v St Peters | The Rectory Field, Blackheath | Results |
| 01 May 2022 | Group 15 Preliminary Round | Bickley Park v Banstead | Bickley Park Road, Bickley | Results |
| 22 May 2022 | Group 15 First Round | Preston Nomads v Wimbledon | Spen Cama Memorial Ground, Fulking | Results |
| 15 May 2022 | Group 15 First Round | Sandwich Town v Three Bridges | The Butts, Sandwich | Results |
| 15 May 2022 | Group 15 First Round | East Molesey v Blackheath | Memorial Cricket Ground, East Molesey | Results |
| 22 May 2022 | Group 15 First Round | Roffey v Bickley Park | Crawley Road, Horsham | Results |
| 29 May 2022 | Group 15 Second Round | Wimbledon v Sandwich Town | Church Road, Wimbledon | Results |
| 29 May 2022 | Group 15 Second Round | Blackheath v Roffey | North Parade, Bath | Results |
| 19 Jun 2022 | Group 15 Third Round | Sandwich Town v Blackheath | The Butts, Sandwich | Results |
| 01 May 2022 | Group 16 Preliminary Round | Ashtead v Dartford | Woodfield Lane, Ashtead | Results |
| 01 May 2022 | Group 16 Preliminary Round | Esher v Crawley | New Road, Esher | Results |
| 01 May 2022 | Group 16 Preliminary Round | Middleton-on-Sea v Bromley Common | Sea Lane, Middleton-on-Sea | Results |
| 01 May 2022 | Group 16 Preliminary Round | Reigate Priory v Whitstable | Park Lane, Reigate | Results |
| 01 May 2022 | Group 16 Preliminary Round | Tunbridge Wells v Bognor Regis | The Nevill Ground, Tunbridge Wells | Results |
| 01 May 2022 | Group 16 Preliminary Round | Eastbourne v Minster (Sheppey) | The Saffrons, Eastbourne | Results |
| 15 May 2022 | Group 16 First Round | Bexley v Ashtead | Manor Way, Bexley | Results |
| 22 May 2022 | Group 16 First Round | Esher v Middleton-on-Sea | New Road, Esher | Results |
| 15 May 2022 | Group 16 First Round | East Grinstead v Reigate Priory | East Grinstead Sports Club Ground, East Grinstead | Results |
| 22 May 2022 | Group 16 First Round | Tunbridge Wells v Minster (Sheppey) | The Nevill Ground, Tunbridge Wells | Results |
| 29 May 2022 | Group 16 Second Round | Bexley v Esher | Manor Way, Bexley | Results |
| 29 May 2022 | Group 16 Second Round | East Grinstead v Tunbridge Wells | East Grinstead Sports Club Ground, East Grinstead | Results |
| 26 Jun 2022 | Group 16 Third Round | Bexley v East Grinstead | Manor Way, Bexley | Results |
| 10 Jul 2022 | Fourth Round | Sandiacre Town v Nantwich | Longmoor Lane, Sandiacre | Results |
| 10 Jul 2022 | Fourth Round | Porthill Park v Kimberley Institute | Knutton Road, Wolstanton | Results |
| 10 Jul 2022 | Fourth Round | Wallasey v Woodlands | The Kevin McCullagh Oval, Wallasey | Results |
| 10 Jul 2022 | Fourth Round | South Northumberland v Northern | Roseworth Terrace, Gosforth | Results |
| 10 Jul 2022 | Fourth Round | Brentwood v Bexley | Old County Ground, Brentwood | Results |
| 10 Jul 2022 | Fourth Round | Sandwich Town v Wanstead and Snaresbrook | The Butts, Sandwich | Results |
| 10 Jul 2022 | Fourth Round | Bridgwater v Potterne | The Parks, Bridgwater | Results |
| 10 Jul 2022 | Fourth Round | Aston Rowant v Sunbury | The Butts Way, Kingston Blount | Results |
| 31 Jul 2022 | Quarter-Final | Wallasey v South Northumberland | The Kevin McCullagh Oval, Wallasey | Results |
| 31 Jul 2022 | Quarter-Final | Bexley v Wanstead and Snaresbrook | Manor Way, Bexley | Results |
| 31 Jul 2022 | Quarter-Final | Nantwich v Kimberley Institute | Whitehouse Lane, Nantwich | Results |
| 31 Jul 2022 | Quarter-Final | Potterne v Aston Rowant | The Grove, Potterne | Results |
| 21 Aug 2022 | Semi-Final | Bexley v Potterne | Manor Way, Bexley | Results |
| 21 Aug 2022 | Semi-Final | Nantwich v Wallasey | Whitehouse Lane, Nantwich | Results |
| 17 Sep 2022 | Final | Bexley v Nantwich | Lord's Cricket Ground, St John's Wood | Results |
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