| 16 May 2022 | Central Division | Somerset Second XI v Worcestershire Second XI | Taunton Vale Sports Club Ground, Taunton | Results |
| 16 May 2022 | Central Division | Warwickshire Second XI v Glamorgan Second XI | Edgbaston Foundation Community Sports Ground, Birmingham | Results |
| 16 May 2022 | North Division | Yorkshire Second XI v Durham Second XI | Weetwood Playing Fields, Leeds | Results |
| 16 May 2022 | North Division | Yorkshire Second XI v Durham Second XI | Weetwood Playing Fields, Leeds | Results |
| 16 May 2022 | North Division | Leicestershire Second XI v Lancashire Second XI | Kibworth Cricket Club New Ground, Kibworth | Results |
| 16 May 2022 | North Division | Leicestershire Second XI v Lancashire Second XI | Kibworth Cricket Club New Ground, Kibworth | Results |
| 16 May 2022 | North Division | Nottinghamshire Second XI v Derbyshire Second XI | Worksop College Ground, Worksop | Results |
| 16 May 2022 | South Division | Surrey Second XI v Essex Second XI | London School of Economics Sports Ground, New Malden | Results |
| 17 May 2022 | Central Division | Northamptonshire Second XI v Gloucestershire Second XI | County Ground, Northampton | Results |
| 17 May 2022 | Central Division | Northamptonshire Second XI v Gloucestershire Second XI | County Ground, Northampton | Results |
| 17 May 2022 | Central Division | Worcestershire Second XI v Glamorgan Second XI | Visit Worcestershire New Road, Worcester | Results |
| 17 May 2022 | North Division | Derbyshire Second XI v Leicestershire Second XI | Racecourse Ground, Derby | Results |
| 17 May 2022 | South Division | Kent Second XI v Middlesex Second XI | Polo Farm Sports Club, Canterbury | Results |
| 17 May 2022 | South Division | Sussex Second XI v Surrey Second XI | Spen Cama Memorial Ground, Fulking | Results |
| 18 May 2022 | Central Division | Warwickshire Second XI v Gloucestershire Second XI | Edgbaston Foundation Community Sports Ground, Birmingham | Results |
| 18 May 2022 | Central Division | Glamorgan Second XI v Somerset Second XI | Sophia Gardens, Cardiff | Results |
| 18 May 2022 | North Division | Durham Second XI v Nottinghamshire Second XI | Seat Unique Riverside Ground, Chester-le-Street | Results |
| 18 May 2022 | North Division | Durham Second XI v Nottinghamshire Second XI | Seat Unique Riverside Ground, Chester-le-Street | Results |
| 18 May 2022 | South Division | Essex Second XI v Middlesex Second XI | Garon Park, Southend-on-Sea | Results |
| 18 May 2022 | South Division | Hampshire Second XI v Sussex Second XI | Utilita Bowl, Southampton | Results |
| 19 May 2022 | Central Division | Somerset Second XI v Northamptonshire Second XI | Taunton Vale Sports Club Ground, Taunton | Results |
| 19 May 2022 | Central Division | Somerset Second XI v Northamptonshire Second XI | Taunton Vale Sports Club Ground, Taunton | Results |
| 19 May 2022 | Central Division | Worcestershire Second XI v Warwickshire Second XI | Cherry Hill Road, Barnt Green | Results |
| 19 May 2022 | North Division | Derbyshire Second XI v Lancashire Second XI | Racecourse Ground, Derby | Results |
| 19 May 2022 | South Division | Hampshire Second XI v Essex Second XI | Utilita Bowl, Southampton | Results |
| 19 May 2022 | South Division | Hampshire Second XI v Essex Second XI | Utilita Bowl, Southampton | Results |
| 20 May 2022 | Central Division | Glamorgan Second XI v Worcestershire Second XI | Deepweir, Caldicot | Results |
| 20 May 2022 | Central Division | Somerset Second XI v Gloucestershire Second XI | Taunton Vale Sports Club Ground, Taunton | Results |
| 20 May 2022 | North Division | Leicestershire Second XI v Durham Second XI | Uptonsteel County Ground, Leicester | Results |
| 20 May 2022 | North Division | Leicestershire Second XI v Durham Second XI | Uptonsteel County Ground, Leicester | Results |
| 20 May 2022 | South Division | Kent Second XI v Sussex Second XI | The Kent County Cricket Ground, Beckenham | Results |
| 20 May 2022 | South Division | Kent Second XI v Sussex Second XI | The Kent County Cricket Ground, Beckenham | Results |
| 23 May 2022 | Central Division | Gloucestershire Second XI v Glamorgan Second XI | Seat Unique Stadium, Bristol | Results |
| 23 May 2022 | North Division | Leicestershire Second XI v Derbyshire Second XI | Uptonsteel County Ground, Leicester | Results |
| 23 May 2022 | North Division | Yorkshire Second XI v Lancashire Second XI | Town Fields, Doncaster | Results |
| 23 May 2022 | South Division | Essex Second XI v Kent Second XI | The Cloud County Ground, Chelmsford | Results |
| 23 May 2022 | South Division | Essex Second XI v Kent Second XI | The Cloud County Ground, Chelmsford | Results |
| 23 May 2022 | South Division | Hampshire Second XI v Middlesex Second XI | Utilita Bowl, Southampton | Results |
| 23 May 2022 | South Division | Surrey Second XI v Sussex Second XI | The Kia Oval, Kennington | Results |
| 24 May 2022 | Central Division | Glamorgan Second XI v Gloucestershire Second XI | Spytty Park, Newport | Results |
| 24 May 2022 | Central Division | Warwickshire Second XI v Northamptonshire Second XI | Edgbaston Foundation Community Sports Ground, Birmingham | Results |
| 24 May 2022 | Central Division | Warwickshire Second XI v Northamptonshire Second XI | Edgbaston Foundation Community Sports Ground, Birmingham | Results |
| 24 May 2022 | Central Division | Worcestershire Second XI v Somerset Second XI | Visit Worcestershire New Road, Worcester | Results |
| 24 May 2022 | North Division | Derbyshire Second XI v Nottinghamshire Second XI | Racecourse Ground, Derby | Results |
| 24 May 2022 | South Division | Surrey Second XI v Middlesex Second XI | The Kia Oval, Kennington | Results |
| 24 May 2022 | South Division | Sussex Second XI v Hampshire Second XI | Cricket Field Road, Horsham | Results |
| 25 May 2022 | Central Division | Warwickshire Second XI v Somerset Second XI | Edgbaston Foundation Community Sports Ground, Birmingham | Results |
| 25 May 2022 | North Division | Yorkshire Second XI v Leicestershire Second XI | Town Fields, Doncaster | Results |
| 25 May 2022 | South Division | Kent Second XI v Hampshire Second XI | The Kent County Cricket Ground, Beckenham | Results |
| 25 May 2022 | South Division | Kent Second XI v Hampshire Second XI | The Kent County Cricket Ground, Beckenham | Results |
| 25 May 2022 | South Division | Sussex Second XI v Middlesex Second XI | Cricket Field Road, Horsham | Results |
| 26 May 2022 | North Division | Nottinghamshire Second XI v Lancashire Second XI | Worksop College Ground, Worksop | Results |
| 26 May 2022 | North Division | Nottinghamshire Second XI v Lancashire Second XI | Worksop College Ground, Worksop | Results |
| 26 May 2022 | South Division | Hampshire Second XI v Surrey Second XI | Utilita Bowl, Southampton | Results |
| 27 May 2022 | North Division | Derbyshire Second XI v Yorkshire Second XI | Queen's Park, Chesterfield | Results |
| 27 May 2022 | North Division | Derbyshire Second XI v Yorkshire Second XI | Queen's Park, Chesterfield | Results |
| 27 May 2022 | South Division | Middlesex Second XI v Essex Second XI | Merchant Taylors' School Ground, Northwood | Results |
| 27 May 2022 | South Division | Surrey Second XI v Kent Second XI | London School of Economics Sports Ground, New Malden | Results |
| 29 May 2022 | South Division | Kent Second XI v Surrey Second XI | The Kent County Cricket Ground, Beckenham | Results |
| 30 May 2022 | Central Division | Somerset Second XI v Glamorgan Second XI | Taunton Vale Sports Club Ground, Taunton | Results |
| 30 May 2022 | Central Division | Warwickshire Second XI v Worcestershire Second XI | Edgbaston Foundation Community Sports Ground, Birmingham | Results |
| 30 May 2022 | North Division | Lancashire Second XI v Derbyshire Second XI | Stanley Park, Blackpool | Results |
| 30 May 2022 | North Division | Leicestershire Second XI v Yorkshire Second XI | Uptonsteel County Ground, Leicester | Results |
| 30 May 2022 | South Division | Middlesex Second XI v Sussex Second XI | Merchant Taylors' School Ground, Northwood | Results |
| 30 May 2022 | South Division | Surrey Second XI v Hampshire Second XI | London School of Economics Sports Ground, New Malden | Results |
| 31 May 2022 | Central Division | Glamorgan Second XI v Northamptonshire Second XI | Spytty Park, Newport | Results |
| 31 May 2022 | Central Division | Glamorgan Second XI v Northamptonshire Second XI | Spytty Park, Newport | Results |
| 31 May 2022 | Central Division | Gloucestershire Second XI v Worcestershire Second XI | College Ground, Cheltenham | Results |
| 31 May 2022 | Central Division | Gloucestershire Second XI v Worcestershire Second XI | College Ground, Cheltenham | Results |
| 31 May 2022 | North Division | Leicestershire Second XI v Nottinghamshire Second XI | Uptonsteel County Ground, Leicester | Results |
| 31 May 2022 | South Division | Essex Second XI v Sussex Second XI | Garon Park, Southend-on-Sea | Results |
| 31 May 2022 | South Division | Middlesex Second XI v Kent Second XI | Merchant Taylors' School Ground, Northwood | Results |
| 01 Jun 2022 | Central Division | Gloucestershire Second XI v Warwickshire Second XI | College Ground, Cheltenham | Results |
| 01 Jun 2022 | North Division | Durham Second XI v Derbyshire Second XI | Ropery Lane, Chester-le-Street | Results |
| 01 Jun 2022 | North Division | Durham Second XI v Derbyshire Second XI | Ropery Lane, Chester-le-Street | Results |
| 01 Jun 2022 | North Division | Lancashire Second XI v Yorkshire Second XI | Stanley Park, Blackpool | Results |
| 01 Jun 2022 | North Division | Nottinghamshire Second XI v Leicestershire Second XI | Gorse Lane, Grantham | Results |
| 01 Jun 2022 | South Division | Essex Second XI v Surrey Second XI | Garon Park, Southend-on-Sea | Results |
| 02 Jun 2022 | Central Division | Glamorgan Second XI v Warwickshire Second XI | Spytty Park, Newport | Results |
| 02 Jun 2022 | Central Division | Gloucestershire Second XI v Somerset Second XI | College Ground, Cheltenham | Results |
| 02 Jun 2022 | Central Division | Northamptonshire Second XI v Worcestershire Second XI | County Ground, Northampton | Results |
| 02 Jun 2022 | Central Division | Northamptonshire Second XI v Worcestershire Second XI | County Ground, Northampton | Results |
| 02 Jun 2022 | South Division | Middlesex Second XI v Surrey Second XI | Merchant Taylors' School Ground, Northwood | Results |
| 02 Jun 2022 | South Division | Sussex Second XI v Essex Second XI | New County Ground, Hove | Results |
| 03 Jun 2022 | Central Division | Somerset Second XI v Warwickshire Second XI | Taunton Vale Sports Club Ground, Taunton | Results |
| 03 Jun 2022 | North Division | Lancashire Second XI v Durham Second XI | The Tyldesleys, Westhoughton | Results |
| 03 Jun 2022 | North Division | Lancashire Second XI v Durham Second XI | The Tyldesleys, Westhoughton | Results |
| 03 Jun 2022 | North Division | Yorkshire Second XI v Nottinghamshire Second XI | St George's Road, Harrogate | Results |
| 03 Jun 2022 | North Division | Yorkshire Second XI v Nottinghamshire Second XI | St George's Road, Harrogate | Results |
| 03 Jun 2022 | South Division | Middlesex Second XI v Hampshire Second XI | Merchant Taylors' School Ground, Northwood | Results |
| 09 Jun 2022 | Final | Glamorgan Second XI v Leicestershire Second XI | Arundel Castle Cricket Club Ground, Arundel | Results |
| 09 Jun 2022 | Semi-Final | Leicestershire Second XI v Nottinghamshire Second XI | Arundel Castle Cricket Club Ground, Arundel | Results |
| 09 Jun 2022 | Semi-Final | Glamorgan Second XI v Middlesex Second XI | Arundel Castle Cricket Club Ground, Arundel | Results |
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