| 21 May 1980 | First Round | Normanby Park Works Second XI v Broughton | Foxhills Sports Ground, Scunthorpe | Results |
| 23 Jul 1980 | Regional Final | Appleby Frodingham v Normanby Park Works Second XI | Cemetery Road Sports Ground, Brumby | Results |
| 19 May 1980 | Zone A First Round | Alkborough v Messingham | West Halton Lane, Alkborough | Results |
| 19 May 1980 | Zone D First Round | Rustons v Hykeham | Newark Road, Lincoln | Results |
| 02 Jun 1980 | Zone A Quarter-Final | Messingham v Scunthorpe Town | Memorial Playing Field, Messingham | Results |
| 02 Jun 1980 | Zone A Quarter-Final | Normanby Park Works v Broughton | Cemetery Road Sports Ground, Brumby | Results |
| 02 Jun 1980 | Zone A Quarter-Final | Nuform Sports v Normanby Park | Nuform Ground, Scunthorpe | Results |
| 02 Jun 1980 | Zone A Quarter-Final | Brigg Town v Appleby Frodingham | Brigg Recreation Ground, Brigg | Results |
| 02 Jun 1980 | Zone B Quarter-Final | Nettleton Mines v Immingham British Rail Sports Association | Lysaghts Sports Ground, Holton le Moor | Results |
| 31 May 1980 | Zone B Quarter-Final | Grimsby Town v East Halton | Augusta Street, Grimsby | Results |
| 02 Jun 1980 | Zone B Quarter-Final | Healing Clee Rovers v Cromwell Drewery | Oak Road, Healing | Results |
| 02 Jun 1980 | Zone B Quarter-Final | Caistor Town v Barton Town | Brigg Road Ground, Caistor | Results |
| 02 Jun 1980 | Zone C Quarter-Final | Skegness v Holton-le-Clay | Richmond Drive, Skegness | Results |
| 02 Jun 1980 | Zone C Quarter-Final | Grimsby British Rail Sports Association v Ross Sports | Carr Lane, Grimsby | Results |
| 02 Jun 1980 | Zone C Quarter-Final | Cleethorpes v Market Rasen | Sports Ground, Cleethorpes | Results |
| 02 Jun 1980 | Zone D Quarter-Final | Southcliffe St Andrews v not known | Sobraon Barracks, Lincoln | Results |
| 02 Jun 1980 | Zone D Quarter-Final | St John's Hospital v Waddington | St John's Hospital, Bracebridge Heath | Results |
| 02 Jun 1980 | Zone D Quarter-Final | Ruston Bucyrus v Hartsholme | Ruston-Bucyrus Ground, Lincoln | Results |
| 02 Jun 1980 | Zone D Quarter-Final | Saxilby v Lincoln Claytons | Saxilby Sports Association Ground, Saxilby | Results |
| 30 Jun 1980 | Zone A Semi-Final | Appleby Frodingham v Normanby Park | Brumby Hall, Scunthorpe | Results |
| 30 Jun 1980 | Zone A Semi-Final | Scunthorpe Town v Normanby Park Works | Heslam Park, Scunthorpe | Results |
| 30 Jun 1980 | Zone B Semi-Final | not known v not known | not known | Results |
| 30 Jun 1980 | Zone B Semi-Final | not known v not known | not known | Results |
| 30 Jun 1980 | Zone C Semi-Final | not known v Ross Sports | not known | Results |
| 30 Jun 1980 | Zone C Semi-Final | not known v not known | not known | Results |
| 30 Jun 1980 | Zone D Semi-Final | Ruston Bucyrus v not known | Ruston-Bucyrus Ground, Lincoln | Results |
| 30 Jun 1980 | Zone D Semi-Final | not known v not known | not known | Results |
| 28 Jul 1980 | Zone B Final | not known v not known | not known | Results |
| 28 Jul 1980 | Zone C Final | not known v Ross Sports | not known | Results |
| 28 Jul 1980 | Zone D Final | Ruston Bucyrus v not known | Ruston-Bucyrus Ground, Lincoln | Results |
| 31 Aug 1980 | Semi-Final | Ruston Bucyrus v not known | Ruston-Bucyrus Ground, Lincoln | Results |
| 31 Aug 1980 | Semi-Final | Normanby Park Works v Ross Sports | Cemetery Road Sports Ground, Brumby | Results |
| 07 Sep 1980 | Final | Ross Sports v Ruston Bucyrus | Augusta Street, Grimsby | Results |
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