| 14 May 2022 | Group 2 | Lightning v Northern Diamonds | Haslegrave Ground, Loughborough | Results |
| 14 May 2022 | Group 1 | Western Storm v Central Sparks | Sophia Gardens, Cardiff | Results |
| 14 May 2022 | Group 2 | Southern Vipers v Thunder | New County Ground, Hove | Results |
| 14 May 2022 | Group 1 | Sunrisers v South East Stars | The Cloud County Ground, Chelmsford | Results |
| 18 May 2022 | Group 2 | Southern Vipers v Lightning | Utilita Bowl, Southampton | Results |
| 18 May 2022 | Group 1 | South East Stars v Central Sparks | Woodbridge Road, Guildford | Results |
| 18 May 2022 | Group 2 | Thunder v Northern Diamonds | Rookwood, Sale | Results |
| 18 May 2022 | Group 1 | Sunrisers v Western Storm | The Cloud County Ground, Chelmsford | Results |
| 21 May 2022 | Group 1 | South East Stars v Western Storm | The Kent County Cricket Ground, Beckenham | Results |
| 21 May 2022 | Group 1 | Central Sparks v Sunrisers | Edgbaston, Birmingham | Results |
| 21 May 2022 | Group 2 | Northern Diamonds v Southern Vipers | Seat Unique Riverside Ground, Chester-le-Street | Results |
| 21 May 2022 | Group 2 | Lightning v Thunder | Uptonsteel County Ground, Leicester | Results |
| 29 May 2022 | Group 1 | Central Sparks v South East Stars | Edgbaston, Birmingham | Results |
| 29 May 2022 | Group 2 | Northern Diamonds v Thunder | Headingley, Leeds | Results |
| 29 May 2022 | Group 1 | Western Storm v Sunrisers | The Cooper Associates County Ground, Taunton | Results |
| 29 May 2022 | Group 2 | Lightning v Southern Vipers | Trent Bridge, Nottingham | Results |
| 01 Jun 2022 | Group 1 | Western Storm v South East Stars | Seat Unique Stadium, Bristol | Results |
| 01 Jun 2022 | Group 2 | Thunder v Southern Vipers | Emirates Old Trafford, Manchester | Results |
| 01 Jun 2022 | Group 2 | Northern Diamonds v Lightning | Seat Unique Riverside Ground, Chester-le-Street | Results |
| 01 Jun 2022 | Group 1 | Sunrisers v Central Sparks | County Ground, Northampton | Results |
| 04 Jun 2022 | Group 2 | Southern Vipers v Northern Diamonds | Utilita Bowl, Southampton | Results |
| 03 Jun 2022 | Group 2 | Thunder v Lightning | Emirates Old Trafford, Manchester | Results |
| 05 Jun 2022 | Group 1 | South East Stars v Sunrisers | Woodbridge Road, Guildford | Results |
| 04 Jun 2022 | Group 1 | Central Sparks v Western Storm | Visit Worcestershire New Road, Worcester | Results |
| 11 Jun 2022 | Final | Central Sparks v Southern Vipers | County Ground, Northampton | Results |
| 11 Jun 2022 | Semi-Final | Central Sparks v South East Stars | County Ground, Northampton | Results |
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