| 20 May 2018 | First Round | Farnworth v Todmorden | Bridgeman Park, Farnworth | Results |
| 20 May 2018 | First Round | Read v Penwortham | Whalley Road, Read | Results |
| 20 May 2018 | First Round | Blackpool v Norley Hall | Stanley Park, Blackpool | Results |
| 20 May 2018 | First Round | Northern v Littleborough | Moor Park, Great Crosby | Results |
| 20 May 2018 | First Round | Walsden v Formby | Scott Street, Walsden | Results |
| 20 May 2018 | First Round | Oswaldtwistle Immanuel v Greenfield | New Lane, Oswaldtwistle | Results |
| 20 May 2018 | First Round | Sutton v Farnworth Social Circle | New Street, Sutton | Results |
| 20 May 2018 | First Round | Kearsley v Crompton | Springfield Road, Kearsley | Results |
| 20 May 2018 | First Round | Settle v Woodbank | Marshfield, Settle | Results |
| 20 May 2018 | First Round | Nelson v Clifton | Seedhill, Nelson | Results |
| 20 May 2018 | First Round | Walkden v Rainhill | The Oval, Walkden | Results |
| 20 May 2018 | First Round | Monton and Weaste v Westhoughton | Welbeck Road, Eccles | Results |
| 20 May 2018 | First Round | Clitheroe v Chorley | Chatburn Road, Clitheroe | Results |
| 20 May 2018 | First Round | Lytham v Eccleston | Church Road, Lytham St Annes | Results |
| 20 May 2018 | First Round | Burnley v Longridge | The boohoo.com Turf Moor, Burnley | Results |
| 20 May 2018 | First Round | Leyland v Fleetwood | The John Stanning Memorial Cricket Ground, Leyland | Results |
| 20 May 2018 | First Round | Denton St Lawrence v Euxton | Sycamore Park, Denton | Results |
| 20 May 2018 | First Round | Fulwood and Broughton v Whalley | Highfield, Broughton | Results |
| 20 May 2018 | First Round | Ormskirk v Prestwich | Brook Lane, Ormskirk | Results |
| 20 May 2018 | First Round | Barnoldswick v Prestwich | Victory Park, Barnoldswick | Results |
| 20 May 2018 | First Round | Roe Green v Vernon Carus | Greenleach Lane, Roe Green | Results |
| 20 May 2018 | First Round | Flixton v Elite | Lawrence Road, Flixton | Results |
| 20 May 2018 | First Round | Leigh v Darwen | Beech Walk, Leigh | Results |
| 20 May 2018 | First Round | Denton West v Bootle | Windsor Park, Denton | Results |
| 20 May 2018 | First Round | Garstang v Penrith | Riverside Sports Ground, Garstang | Results |
| 20 May 2018 | First Round | Salesbury v Horwich RMI | Ribchester Road, Salesbury | Results |
| 20 May 2018 | First Round | Great Eccleston v Lowerhouse | Hall Lane, Great Eccleston | Results |
| 20 May 2018 | First Round | Rochdale v Bradshaw | Redbrook, Rochdale | Results |
| 10 Jun 2018 | Second Round | Todmorden v Penwortham | Centre Vale, Todmorden | Results |
| 10 Jun 2018 | Second Round | Farnworth Social Circle v Crompton | Piggott Park, Farnworth | Results |
| 10 Jun 2018 | Second Round | Walkden v Westhoughton | The Oval, Walkden | Results |
| 10 Jun 2018 | Second Round | Burnley v Leyland | The boohoo.com Turf Moor, Burnley | Results |
| 10 Jun 2018 | Second Round | Denton St Lawrence v Fulwood and Broughton | Sycamore Park, Denton | Results |
| 10 Jun 2018 | Second Round | Elite v Darwen | The Brookhouse Aerospace Birch Hall Cricket Ground, Darwen | Results |
| 10 Jun 2018 | Second Round | Penrith v Salesbury | Tynefield Park, Penrith | Results |
| 10 Jun 2018 | Second Round | Walsden v Greenfield | Scott Street, Walsden | Results |
| 10 Jun 2018 | Second Round | Netherfield v Ramsbottom | Parkside Road, Kendal | Results |
| 10 Jun 2018 | Second Round | Woodbank v Clifton | The Kenyons, Bury | Results |
| 10 Jun 2018 | Second Round | Chorley v Eccleston | Windsor Park, Chorley | Results |
| 10 Jun 2018 | Second Round | Norden v Roe Green | Woodhouse Lane, Norden | Results |
| 10 Jun 2018 | Second Round | Ormskirk v Barnoldswick | Brook Lane, Ormskirk | Results |
| 10 Jun 2018 | Second Round | St Annes v Bootle | Vernon Road, St Annes | Results |
| 10 Jun 2018 | Second Round | Blackpool v Northern | Stanley Park, Blackpool | Results |
| 10 Jun 2018 | Second Round | Lowerhouse v Rochdale | The Brooks Foundation Ground, Lowerhouse | Results |
| 01 Jul 2018 | Third Round | Todmorden v Northern | Centre Vale, Todmorden | Results |
| 01 Jul 2018 | Third Round | Clifton v Walkden | Manchester Road, Clifton | Results |
| 01 Jul 2018 | Third Round | Chorley v Leyland | Windsor Park, Chorley | Results |
| 01 Jul 2018 | Third Round | Netherfield v Denton St Lawrence | Parkside Road, Kendal | Results |
| 01 Jul 2018 | Third Round | Ormskirk v Roe Green | Brook Lane, Ormskirk | Results |
| 01 Jul 2018 | Third Round | Darwen v Bootle | The Brookhouse Aerospace Birch Hall Cricket Ground, Darwen | Results |
| 01 Jul 2018 | Third Round | Penrith v Rochdale | Tynefield Park, Penrith | Results |
| 01 Jul 2018 | Third Round | Walsden v Crompton | Scott Street, Walsden | Results |
| 22 Jul 2018 | Quarter-Final | Northern v Walsden | Moor Park, Great Crosby | Results |
| 22 Jul 2018 | Quarter-Final | Clifton v Leyland | Manchester Road, Clifton | Results |
| 22 Jul 2018 | Quarter-Final | Netherfield v Ormskirk | Parkside Road, Kendal | Results |
| 22 Jul 2018 | Quarter-Final | Darwen v Rochdale | The Brookhouse Aerospace Birch Hall Cricket Ground, Darwen | Results |
| 19 Aug 2018 | Semi-Final | Ormskirk v Darwen | Brook Lane, Ormskirk | Results |
| 19 Aug 2018 | Semi-Final | Northern v Clifton | Moor Park, Great Crosby | Results |
| 02 Sep 2018 | Final | Darwen v Clifton | Brook Lane, Ormskirk | Results |
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