| 02 May 2016 | First Round | Burnmoor Second XI v Tudhoe Second XI | Village Ground, Burnmoor | Results |
| 02 May 2016 | First Round | Chester-le-Street Second XI v Whitburn Second XI | Ropery Lane, Chester-le-Street | Results |
| 02 May 2016 | First Round | Eppleton Second XI v Boldon Second XI | Church Road, Hetton-le-Hole | Results |
| 02 May 2016 | First Round | Newcastle Second XI v Benwell Hill Second XI | Osborne Avenue, Jesmond | Results |
| 02 May 2016 | First Round | Sacriston Second XI v Seaham Harbour Second XI | Front Street, Sacriston | Results |
| 02 May 2016 | First Round | Tynemouth Second XI v Sunderland Second XI | Preston Avenue, North Shields | Results |
| 02 May 2016 | First Round | Willington Second XI v Blaydon Second XI | Manor Road, Low Willington | Results |
| 05 Jun 2016 | Second Round | Chester-le-Street Second XI v South Shields Second XI | Ropery Lane, Chester-le-Street | Results |
| 05 Jun 2016 | Second Round | Brandon Second XI v Newcastle Second XI | Brandon Lane, Brandon | Results |
| 05 Jun 2016 | Second Round | Willington Second XI v Gateshead Fell Second XI | Manor Road, Low Willington | Results |
| 05 Jun 2016 | Second Round | Tynemouth Second XI v Mainsforth Second XI | Preston Avenue, North Shields | Results |
| 05 Jun 2016 | Second Round | Stockton Second XI v Burnmoor Second XI | Grangefield Road, Stockton-on-Tees | Results |
| 05 Jun 2016 | Second Round | Sacriston Second XI v Felling Second XI | Front Street, Sacriston | Results |
| 05 Jun 2016 | Second Round | Hetton Lyons Second XI v South Northumberland Second XI | Lilywhite Terrace, Hetton-le-Hole | Results |
| 05 Jun 2016 | Second Round | Eppleton Second XI v Washington Second XI | Church Road, Hetton-le-Hole | Results |
| 03 Jul 2016 | Quarter-Final | Willington Second XI v Tynemouth Second XI | Manor Road, Low Willington | Results |
| 17 Jul 2016 | Quarter-Final | Stockton Second XI v South Northumberland Second XI | Grangefield Road, Stockton-on-Tees | Results |
| 24 Jul 2016 | Quarter-Final | Washington Second XI v Newcastle Second XI | Vigo Lane, Washington | Results |
| 31 Jul 2016 | Quarter-Final | Chester-le-Street Second XI v Sacriston Second XI | Ropery Lane, Chester-le-Street | Results |
| 31 Jul 2016 | Semi-Final | South Northumberland Second XI v Tynemouth Second XI | Roseworth Terrace, Gosforth | Results |
| 14 Aug 2016 | Semi-Final | Chester-le-Street Second XI v Newcastle Second XI | Ropery Lane, Chester-le-Street | Results |
| 29 Aug 2016 | Final | Chester-le-Street Second XI v Tynemouth Second XI | Ropery Lane, Chester-le-Street | Results |
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