| 21 Nov 1980 | Northern Section | Transvaal B v Orange Free State | New Wanderers No 1 Oval, Johannesburg | Results |
| 22 Nov 1980 | Southern Section | Western Province B v Border | Claremont Cricket Club, Cape Town | Results |
| 27 Nov 1980 | Southern Section | Boland v Border | Oude Libertas, Stellenbosch Farmers Winery Ground, Stellenbosch | Results |
| 27 Nov 1980 | Northern Section | Griqualand West v Natal B | De Beers Diamond Oval, Kimberley | Results |
| 11 Dec 1980 | Southern Section | Eastern Province B v Border | Rhodes University Prospect Field, Grahamstown | Results |
| 11 Dec 1980 | Northern Section | Griqualand West v Transvaal B | De Beers Diamond Oval, Kimberley | Results |
| 11 Dec 1980 | Northern Section | Orange Free State v Natal B | Ramblers Cricket Club Ground, Bloemfontein | Results |
| 12 Dec 1980 | Southern Section | Boland v Western Province B | Oude Libertas, Stellenbosch Farmers Winery Ground, Stellenbosch | Results |
| 26 Dec 1980 | Southern Section | Border v Eastern Province B | Recreation Ground, East London | Results |
| 26 Dec 1980 | Southern Section | Western Province B v Boland | PPC Newlands, Cape Town | Results |
| 01 Jan 1981 | Southern Section | Border v Western Province B | Recreation Ground, East London | Results |
| 01 Jan 1981 | Northern Section | Natal B v Transvaal B | Hollywoodbets Kingsmead, Durban | Results |
| 01 Jan 1981 | Northern Section | Orange Free State v Griqualand West | Ramblers Cricket Club Ground, Bloemfontein | Results |
| 15 Jan 1981 | Southern Section | Eastern Province B v Western Province B | Old Grey Ground, Port Elizabeth | Results |
| 19 Jan 1981 | Northern Section | Transvaal B v Griqualand West | Imperial Wanderers Stadium, Johannesburg | Results |
| 23 Jan 1981 | Northern Section | Natal B v Griqualand West | Jan Smuts Stadium, Pietermaritzburg | Results |
| 23 Jan 1981 | Northern Section | Orange Free State v Transvaal B | Rovers Cricket Club, Welkom | Results |
| 24 Jan 1981 | Southern Section | Border v Boland | Recreation Ground, East London | Results |
| 29 Jan 1981 | Southern Section | Eastern Province B v Boland | Old Grey Ground, Port Elizabeth | Results |
| 05 Feb 1981 | Northern Section | Transvaal B v Natal B | Imperial Wanderers Stadium, Johannesburg | Results |
| 12 Feb 1981 | Northern Section | Natal B v Orange Free State | Hollywoodbets Kingsmead, Durban | Results |
| 14 Feb 1981 | Southern Section | Boland v Eastern Province B | Oude Libertas, Stellenbosch Farmers Winery Ground, Stellenbosch | Results |
| 19 Feb 1981 | Northern Section | Griqualand West v Orange Free State | De Beers Diamond Oval, Kimberley | Results |
| 19 Feb 1981 | Southern Section | Western Province B v Eastern Province B | Claremont Cricket Club, Cape Town | Results |
| 13 Mar 1981 | Final | Transvaal B v Western Province B | Imperial Wanderers Stadium, Johannesburg | Results |
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