| 08 May 2010 | First Round | Baxenden Second XI v Oswaldtwistle Immanuel Second XI | Back Lane, Baxenden | Results |
| 08 May 2010 | First Round | Brinscall Second XI v Padiham Second XI | School Lane, Brinscall | Results |
| 08 May 2010 | First Round | Burnley Belvedere Second XI v Settle Second XI | Holden Road, Reedley | Results |
| 08 May 2010 | First Round | Burnley Grammar School Old Boys Second XI v Feniscowles Second XI | Habergham Community College Ground, Burnley | Results |
| 08 May 2010 | First Round | Clitheroe Second XI v Salesbury Second XI | Chatburn Road, Clitheroe | Results |
| 08 May 2010 | First Round | Edenfield Second XI v Ghyll | Gincroft Lane, Edenfield | Results |
| 08 May 2010 | First Round | Feniscowles v Barnoldswick Second XI | War Memorial Ground, Feniscowles | Results |
| 08 May 2010 | First Round | Ghyll Second XI v Cherry Tree Second XI | Ghyll Lane Sports Ground, Barnoldswick | Results |
| 08 May 2010 | First Round | Read Second XI v Earby Second XI | Whalley Road, Read | Results |
| 08 May 2010 | First Round | Stacksteads Second XI v Stacksteads | New Hall Hey Cricket Ground, Rawtenstall | Results |
| 08 May 2010 | First Round | Whalley Second XI v Burnley Grammar School Old Boys | Station Road, Whalley | Results |
| 23 May 2010 | Second Round | Burnley Belvedere v Brinscall | Holden Road, Reedley | Results |
| 23 May 2010 | Second Round | Cherry Tree Second XI v Burnley Belvedere Second XI | Preston Old Road, Cherry Tree | Results |
| 23 May 2010 | Second Round | Feniscowles Second XI v Baxenden Second XI | War Memorial Ground, Feniscowles | Results |
| 23 May 2010 | Second Round | Great Harwood Second XI v Barnoldswick Second XI | Evolve Document Solutions Cliffe Park, Great Harwood | Results |
| 23 May 2010 | Second Round | Padiham Second XI v Edenfield Second XI | The Arbories Memorial Sports Ground, Padiham | Results |
| 23 May 2010 | Second Round | Ribblesdale Wanderers Second XI v Stacksteads | Church Meadow, Clitheroe | Results |
| 23 May 2010 | Second Round | Whalley Second XI v Salesbury Second XI | Station Road, Whalley | Results |
| 20 Jun 2010 | Quarter-Final | Cherry Tree Second XI v Brinscall | Preston Old Road, Cherry Tree | Results |
| 20 Jun 2010 | Quarter-Final | Great Harwood Second XI v Padiham Second XI | Evolve Document Solutions Cliffe Park, Great Harwood | Results |
| 20 Jun 2010 | Quarter-Final | Ribblesdale Wanderers Second XI v Read Second XI | Church Meadow, Clitheroe | Results |
| 20 Jun 2010 | Quarter-Final | Whalley Second XI v Baxenden Second XI | Station Road, Whalley | Results |
| 04 Jul 2010 | Sem-Final | Baxenden Second XI v Brinscall | Back Lane, Baxenden | Results |
| 04 Jul 2010 | Sem-Final | Ribblesdale Wanderers Second XI v Great Harwood Second XI | Church Meadow, Clitheroe | Results |
| 08 Aug 2010 | Final | Brinscall v Ribblesdale Wanderers Second XI | School Lane, Brinscall | Results |
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