| 06 May 2006 | First Round | Barnoldswick Second XI v Burnley Grammar School Old Boys Second XI | Victory Park, Barnoldswick | Results |
| 06 May 2006 | First Round | Blackburn Northern Second XI v Earby Second XI | Pleckgate Road, Blackburn | Results |
| 06 May 2006 | First Round | Brinscall Second XI v Whalley Second XI | School Lane, Brinscall | Results |
| 06 May 2006 | First Round | Burnley Belvedere Second XI v Clitheroe Second XI | Holden Road, Reedley | Results |
| 06 May 2006 | First Round | Burnley Grammar School Old Boys v Feniscowles Second XI | Habergham Community College Ground, Burnley | Results |
| 06 May 2006 | First Round | Edenfield Second XI v Cherry Tree Second XI | Gincroft Lane, Edenfield | Results |
| 06 May 2006 | First Round | Feniscowles v Brinscall | War Memorial Ground, Feniscowles | Results |
| 06 May 2006 | First Round | Ghyll v Ghyll Second XI | Ghyll Lane Sports Ground, Barnoldswick | Results |
| 06 May 2006 | First Round | Great Harwood Second XI v Stacksteads | Evolve Document Solutions Cliffe Park, Great Harwood | Results |
| 06 May 2006 | First Round | Oswaldtwistle Immanuel Second XI v Baxenden Second XI | New Lane, Oswaldtwistle | Results |
| 06 May 2006 | First Round | Settle Second XI v Padiham Second XI | Marshfield, Settle | Results |
| 06 May 2006 | First Round | Stacksteads Second XI v Salesbury Second XI | New Hall Hey Cricket Ground, Rawtenstall | Results |
| 04 Jun 2006 | Second Round | Barnoldswick Second XI v Salesbury | Victory Park, Barnoldswick | Results |
| 04 Jun 2006 | Second Round | Burnley Belvedere v Baxenden Second XI | Holden Road, Reedley | Results |
| 04 Jun 2006 | Second Round | Clitheroe Second XI v Blackburn Northern Second XI | Chatburn Road, Clitheroe | Results |
| 04 Jun 2006 | Second Round | Great Harwood Second XI v Brinscall | Evolve Document Solutions Cliffe Park, Great Harwood | Results |
| 04 Jun 2006 | Second Round | Read Second XI v Edenfield Second XI | Whalley Road, Read | Results |
| 04 Jun 2006 | Second Round | Ribblesdale Wanderers Second XI v Ghyll | Church Meadow, Clitheroe | Results |
| 04 Jun 2006 | Second Round | Salesbury Second XI v Padiham Second XI | Ribchester Road, Salesbury | Results |
| 04 Jun 2006 | Second Round | Whalley Second XI v Burnley Grammar School Old Boys | Station Road, Whalley | Results |
| 18 Jun 2006 | Quarter-Final | Baxenden Second XI v Ribblesdale Wanderers Second XI | Back Lane, Baxenden | Results |
| 18 Jun 2006 | Quarter-Final | Edenfield Second XI v Padiham Second XI | Gincroft Lane, Edenfield | Results |
| 18 Jun 2006 | Quarter-Final | Salesbury v Clitheroe Second XI | Ribchester Road, Salesbury | Results |
| 18 Jun 2006 | Quarter-Final | Whalley Second XI v Brinscall | Station Road, Whalley | Results |
| 16 Jul 2006 | Semi-Final | Edenfield Second XI v Salesbury | Gincroft Lane, Edenfield | Results |
| 16 Jul 2006 | Semi-Final | Whalley Second XI v Ribblesdale Wanderers Second XI | Station Road, Whalley | Results |
| 13 Aug 2006 | Final | Edenfield Second XI v Ribblesdale Wanderers Second XI | Gincroft Lane, Edenfield | Results |
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