| 27 Apr 1922 | | Burslem v Bignall End | Greyhound Way, Stoke-on-Trent | Results |
| 27 Apr 1922 | | Crewe Alexandra v Cheadle | Alexandra Athletic Ground, Crewe | Results |
| 27 Apr 1922 | | Silverdale v Leek | Underwood Road, Silverdale | Results |
| 27 Apr 1922 | | Knypersley v Caverswall | Tunstall Road, Knypersley | Results |
| 27 Apr 1922 | | Nantwich v Norton | Kingsley Fields, Nantwich | Results |
| 27 Apr 1922 | | Longton v Porthill Park | Trentham Road, Stoke-on-Trent | Results |
| 06 May 1922 | | Cheadle v Burslem | Tean Road Sports Ground, Cheadle | Results |
| 06 May 1922 | | Bignall End v Longton | Boon Hill Road, Bignall End | Results |
| 06 May 1922 | | Leek v Crewe Alexandra | Highfield, Leek | Results |
| 06 May 1922 | | Caverswall v Silverdale | Alan Gott Memorial Ground, Stoke-on-Trent | Results |
| 06 May 1922 | | Norton v Knypersley | Community Drive, Smallthorne | Results |
| 06 May 1922 | | Porthill Park v Nantwich | Knutton Road, Wolstanton | Results |
| 13 May 1922 | | Burslem v Leek | Greyhound Way, Stoke-on-Trent | Results |
| 13 May 1922 | | Bignall End v Cheadle | Boon Hill Road, Bignall End | Results |
| 13 May 1922 | | Crewe Alexandra v Caverswall | Alexandra Athletic Ground, Crewe | Results |
| 13 May 1922 | | Silverdale v Norton | Underwood Road, Silverdale | Results |
| 13 May 1922 | | Knypersley v Porthill Park | Tunstall Road, Knypersley | Results |
| 13 May 1922 | | Longton v Nantwich | Trentham Road, Stoke-on-Trent | Results |
| 20 May 1922 | | Caverswall v Burslem | Alan Gott Memorial Ground, Stoke-on-Trent | Results |
| 20 May 1922 | | Leek v Bignall End | Highfield, Leek | Results |
| 20 May 1922 | | Cheadle v Longton | Tean Road Sports Ground, Cheadle | Results |
| 20 May 1922 | | Norton v Crewe Alexandra | Community Drive, Smallthorne | Results |
| 20 May 1922 | | Porthill Park v Silverdale | Knutton Road, Wolstanton | Results |
| 20 May 1922 | | Nantwich v Knypersley | Kingsley Fields, Nantwich | Results |
| 27 May 1922 | | Burslem v Norton | Greyhound Way, Stoke-on-Trent | Results |
| 27 May 1922 | | Bignall End v Caverswall | Boon Hill Road, Bignall End | Results |
| 27 May 1922 | | Cheadle v Leek | Tean Road Sports Ground, Cheadle | Results |
| 27 May 1922 | | Crewe Alexandra v Porthill Park | Alexandra Athletic Ground, Crewe | Results |
| 27 May 1922 | | Silverdale v Nantwich | Underwood Road, Silverdale | Results |
| 27 May 1922 | | Longton v Knypersley | Trentham Road, Stoke-on-Trent | Results |
| 03 Jun 1922 | | Porthill Park v Burslem | Knutton Road, Wolstanton | Results |
| 03 Jun 1922 | | Norton v Bignall End | Community Drive, Smallthorne | Results |
| 03 Jun 1922 | | Caverswall v Cheadle | Alan Gott Memorial Ground, Stoke-on-Trent | Results |
| 03 Jun 1922 | | Leek v Longton | Highfield, Leek | Results |
| 03 Jun 1922 | | Nantwich v Crewe Alexandra | Kingsley Fields, Nantwich | Results |
| 03 Jun 1922 | | Knypersley v Silverdale | Tunstall Road, Knypersley | Results |
| 05 Jun 1922 | | Burslem v Nantwich | Greyhound Way, Stoke-on-Trent | Results |
| 05 Jun 1922 | | Bignall End v Porthill Park | Boon Hill Road, Bignall End | Results |
| 05 Jun 1922 | | Cheadle v Norton | Tean Road Sports Ground, Cheadle | Results |
| 05 Jun 1922 | | Leek v Caverswall | Highfield, Leek | Results |
| 05 Jun 1922 | | Crewe Alexandra v Knypersley | Alexandra Athletic Ground, Crewe | Results |
| 05 Jun 1922 | | Longton v Silverdale | Trentham Road, Stoke-on-Trent | Results |
| 10 Jun 1922 | | Knypersley v Burslem | Tunstall Road, Knypersley | Results |
| 10 Jun 1922 | | Nantwich v Bignall End | Kingsley Fields, Nantwich | Results |
| 10 Jun 1922 | | Porthill Park v Cheadle | Knutton Road, Wolstanton | Results |
| 10 Jun 1922 | | Norton v Leek | Community Drive, Smallthorne | Results |
| 10 Jun 1922 | | Caverswall v Longton | Alan Gott Memorial Ground, Stoke-on-Trent | Results |
| 10 Jun 1922 | | Silverdale v Crewe Alexandra | Underwood Road, Silverdale | Results |
| 17 Jun 1922 | | Burslem v Silverdale | Greyhound Way, Stoke-on-Trent | Results |
| 17 Jun 1922 | | Bignall End v Knypersley | Boon Hill Road, Bignall End | Results |
| 17 Jun 1922 | | Cheadle v Nantwich | Tean Road Sports Ground, Cheadle | Results |
| 17 Jun 1922 | | Leek v Porthill Park | Highfield, Leek | Results |
| 17 Jun 1922 | | Caverswall v Norton | Alan Gott Memorial Ground, Stoke-on-Trent | Results |
| 17 Jun 1922 | | Longton v Crewe Alexandra | Trentham Road, Stoke-on-Trent | Results |
| 24 Jun 1922 | | Crewe Alexandra v Burslem | Alexandra Athletic Ground, Crewe | Results |
| 24 Jun 1922 | | Silverdale v Bignall End | Underwood Road, Silverdale | Results |
| 24 Jun 1922 | | Knypersley v Cheadle | Tunstall Road, Knypersley | Results |
| 24 Jun 1922 | | Nantwich v Leek | Kingsley Fields, Nantwich | Results |
| 24 Jun 1922 | | Porthill Park v Caverswall | Knutton Road, Wolstanton | Results |
| 24 Jun 1922 | | Longton v Norton | Trentham Road, Stoke-on-Trent | Results |
| 26 Jun 1922 | | Burslem v Longton | Greyhound Way, Stoke-on-Trent | Results |
| 26 Jun 1922 | | Bignall End v Crewe Alexandra | Boon Hill Road, Bignall End | Results |
| 26 Jun 1922 | | Cheadle v Silverdale | Tean Road Sports Ground, Cheadle | Results |
| 26 Jun 1922 | | Leek v Knypersley | Highfield, Leek | Results |
| 26 Jun 1922 | | Caverswall v Nantwich | Alan Gott Memorial Ground, Stoke-on-Trent | Results |
| 26 Jun 1922 | | Norton v Porthill Park | Community Drive, Smallthorne | Results |
| 01 Jul 1922 | | Bignall End v Burslem | Boon Hill Road, Bignall End | Results |
| 01 Jul 1922 | | Cheadle v Crewe Alexandra | Tean Road Sports Ground, Cheadle | Results |
| 01 Jul 1922 | | Leek v Silverdale | Highfield, Leek | Results |
| 01 Jul 1922 | | Caverswall v Knypersley | Alan Gott Memorial Ground, Stoke-on-Trent | Results |
| 01 Jul 1922 | | Norton v Nantwich | Community Drive, Smallthorne | Results |
| 01 Jul 1922 | | Porthill Park v Longton | Knutton Road, Wolstanton | Results |
| 08 Jul 1922 | | Burslem v Cheadle | Greyhound Way, Stoke-on-Trent | Results |
| 08 Jul 1922 | | Longton v Bignall End | Trentham Road, Stoke-on-Trent | Results |
| 08 Jul 1922 | | Crewe Alexandra v Leek | Alexandra Athletic Ground, Crewe | Results |
| 08 Jul 1922 | | Silverdale v Caverswall | Underwood Road, Silverdale | Results |
| 08 Jul 1922 | | Knypersley v Norton | Tunstall Road, Knypersley | Results |
| 08 Jul 1922 | | Nantwich v Porthill Park | Kingsley Fields, Nantwich | Results |
| 15 Jul 1922 | | Leek v Burslem | Highfield, Leek | Results |
| 15 Jul 1922 | | Cheadle v Bignall End | Tean Road Sports Ground, Cheadle | Results |
| 15 Jul 1922 | | Caverswall v Crewe Alexandra | Alan Gott Memorial Ground, Stoke-on-Trent | Results |
| 15 Jul 1922 | | Norton v Silverdale | Community Drive, Smallthorne | Results |
| 15 Jul 1922 | | Porthill Park v Knypersley | Knutton Road, Wolstanton | Results |
| 15 Jul 1922 | | Nantwich v Longton | Kingsley Fields, Nantwich | Results |
| 22 Jul 1922 | | Burslem v Caverswall | Greyhound Way, Stoke-on-Trent | Results |
| 22 Jul 1922 | | Bignall End v Leek | Boon Hill Road, Bignall End | Results |
| 22 Jul 1922 | | Longton v Cheadle | Trentham Road, Stoke-on-Trent | Results |
| 22 Jul 1922 | | Crewe Alexandra v Norton | Alexandra Athletic Ground, Crewe | Results |
| 22 Jul 1922 | | Silverdale v Porthill Park | Underwood Road, Silverdale | Results |
| 22 Jul 1922 | | Knypersley v Nantwich | Tunstall Road, Knypersley | Results |
| 29 Jul 1922 | | Norton v Burslem | Community Drive, Smallthorne | Results |
| 29 Jul 1922 | | Caverswall v Bignall End | Alan Gott Memorial Ground, Stoke-on-Trent | Results |
| 29 Jul 1922 | | Leek v Cheadle | Highfield, Leek | Results |
| 29 Jul 1922 | | Porthill Park v Crewe Alexandra | Knutton Road, Wolstanton | Results |
| 29 Jul 1922 | | Nantwich v Silverdale | Kingsley Fields, Nantwich | Results |
| 29 Jul 1922 | | Knypersley v Longton | Tunstall Road, Knypersley | Results |
| 05 Aug 1922 | | Burslem v Porthill Park | Greyhound Way, Stoke-on-Trent | Results |
| 05 Aug 1922 | | Bignall End v Norton | Boon Hill Road, Bignall End | Results |
| 05 Aug 1922 | | Cheadle v Caverswall | Tean Road Sports Ground, Cheadle | Results |
| 05 Aug 1922 | | Longton v Leek | Trentham Road, Stoke-on-Trent | Results |
| 05 Aug 1922 | | Crewe Alexandra v Nantwich | Alexandra Athletic Ground, Crewe | Results |
| 05 Aug 1922 | | Silverdale v Knypersley | Underwood Road, Silverdale | Results |
| 12 Aug 1922 | | Nantwich v Burslem | Kingsley Fields, Nantwich | Results |
| 12 Aug 1922 | | Porthill Park v Bignall End | Knutton Road, Wolstanton | Results |
| 12 Aug 1922 | | Norton v Cheadle | Community Drive, Smallthorne | Results |
| 12 Aug 1922 | | Caverswall v Leek | Alan Gott Memorial Ground, Stoke-on-Trent | Results |
| 12 Aug 1922 | | Knypersley v Crewe Alexandra | Tunstall Road, Knypersley | Results |
| 12 Aug 1922 | | Silverdale v Longton | Underwood Road, Silverdale | Results |
| 19 Aug 1922 | | Burslem v Knypersley | Greyhound Way, Stoke-on-Trent | Results |
| 19 Aug 1922 | | Bignall End v Nantwich | Boon Hill Road, Bignall End | Results |
| 19 Aug 1922 | | Cheadle v Porthill Park | Tean Road Sports Ground, Cheadle | Results |
| 19 Aug 1922 | | Leek v Norton | Highfield, Leek | Results |
| 19 Aug 1922 | | Longton v Caverswall | Trentham Road, Stoke-on-Trent | Results |
| 19 Aug 1922 | | Crewe Alexandra v Silverdale | Alexandra Athletic Ground, Crewe | Results |
| 26 Aug 1922 | | Silverdale v Burslem | Underwood Road, Silverdale | Results |
| 26 Aug 1922 | | Knypersley v Bignall End | Tunstall Road, Knypersley | Results |
| 26 Aug 1922 | | Nantwich v Cheadle | Kingsley Fields, Nantwich | Results |
| 26 Aug 1922 | | Porthill Park v Leek | Knutton Road, Wolstanton | Results |
| 26 Aug 1922 | | Norton v Caverswall | Community Drive, Smallthorne | Results |
| 26 Aug 1922 | | Crewe Alexandra v Longton | Alexandra Athletic Ground, Crewe | Results |
| 02 Sep 1922 | | Burslem v Crewe Alexandra | Greyhound Way, Stoke-on-Trent | Results |
| 02 Sep 1922 | | Bignall End v Silverdale | Boon Hill Road, Bignall End | Results |
| 02 Sep 1922 | | Cheadle v Knypersley | Tean Road Sports Ground, Cheadle | Results |
| 02 Sep 1922 | | Leek v Nantwich | Highfield, Leek | Results |
| 02 Sep 1922 | | Caverswall v Porthill Park | Alan Gott Memorial Ground, Stoke-on-Trent | Results |
| 02 Sep 1922 | | Norton v Longton | Community Drive, Smallthorne | Results |
| 09 Sep 1922 | | Longton v Burslem | Trentham Road, Stoke-on-Trent | Results |
| 09 Sep 1922 | | Crewe Alexandra v Bignall End | Alexandra Athletic Ground, Crewe | Results |
| 09 Sep 1922 | | Silverdale v Cheadle | Underwood Road, Silverdale | Results |
| 09 Sep 1922 | | Knypersley v Leek | Tunstall Road, Knypersley | Results |
| 09 Sep 1922 | | Nantwich v Caverswall | Kingsley Fields, Nantwich | Results |
| 09 Sep 1922 | | Porthill Park v Norton | Knutton Road, Wolstanton | Results |
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