| 30 Apr 1921 | | Betley v Nantwich | Marl Pit, Betley | Results |
| 30 Apr 1921 | | Burslem High Lane v Shelton Welfare | Burslem High Lane Cricket Club Ground, Burslem | Results |
| 30 Apr 1921 | | Haslington v Kidsgrove | Clay Lane, Haslington | Results |
| 30 Apr 1921 | | North Staffordshire Railway v Madeley | not known | Results |
| 30 Apr 1921 | | Sandyford v Great Chell | Shelford Road, Sandyford | Results |
| 07 May 1921 | | Great Chell v Burslem High Lane | Great Chell Cricket Club Ground, Great Chell | Results |
| 07 May 1921 | | Kidsgrove v Betley | Kinnersley Ground, Kidsgrove | Results |
| 07 May 1921 | | Madeley v Sandyford | Park Street, Madeley | Results |
| 07 May 1921 | | Nantwich v North Staffordshire Railway | Kingsley Fields, Nantwich | Results |
| 07 May 1921 | | Shelton Welfare v Haslington | Shelton Welfare Cricket Club Ground, Stoke-on-Trent | Results |
| 14 May 1921 | | Betley v Shelton Welfare | Marl Pit, Betley | Results |
| 14 May 1921 | | Burslem High Lane v Madeley | Burslem High Lane Cricket Club Ground, Burslem | Results |
| 14 May 1921 | | Haslington v Great Chell | Clay Lane, Haslington | Results |
| 14 May 1921 | | Kidsgrove v Nantwich | Kinnersley Ground, Kidsgrove | Results |
| 14 May 1921 | | Sandyford v North Staffordshire Railway | Shelford Road, Sandyford | Results |
| 16 May 1921 | | Great Chell v Betley | Great Chell Cricket Club Ground, Great Chell | Results |
| 16 May 1921 | | Madeley v Haslington | Park Street, Madeley | Results |
| 16 May 1921 | | North Staffordshire Railway v Burslem High Lane | not known | Results |
| 16 May 1921 | | Nantwich v Sandyford | Kingsley Fields, Nantwich | Results |
| 16 May 1921 | | Shelton Welfare v Kidsgrove | Shelton Welfare Cricket Club Ground, Stoke-on-Trent | Results |
| 21 May 1921 | | Betley v Madeley | Marl Pit, Betley | Results |
| 21 May 1921 | | Burslem High Lane v Sandyford | Burslem High Lane Cricket Club Ground, Burslem | Results |
| 21 May 1921 | | Haslington v North Staffordshire Railway | Clay Lane, Haslington | Results |
| 21 May 1921 | | Kidsgrove v Great Chell | Kinnersley Ground, Kidsgrove | Results |
| 21 May 1921 | | Shelton Welfare v Nantwich | Shelton Welfare Cricket Club Ground, Stoke-on-Trent | Results |
| 28 May 1921 | | Great Chell v Shelton Welfare | Great Chell Cricket Club Ground, Great Chell | Results |
| 28 May 1921 | | Madeley v Kidsgrove | Park Street, Madeley | Results |
| 28 May 1921 | | North Staffordshire Railway v Betley | not known | Results |
| 28 May 1921 | | Nantwich v Burslem High Lane | Kingsley Fields, Nantwich | Results |
| 28 May 1921 | | Sandyford v Haslington | Shelford Road, Sandyford | Results |
| 04 Jun 1921 | | Betley v Sandyford | Marl Pit, Betley | Results |
| 04 Jun 1921 | | Great Chell v Nantwich | Great Chell Cricket Club Ground, Great Chell | Results |
| 04 Jun 1921 | | Haslington v Burslem High Lane | Clay Lane, Haslington | Results |
| 04 Jun 1921 | | Kidsgrove v North Staffordshire Railway | Kinnersley Ground, Kidsgrove | Results |
| 04 Jun 1921 | | Shelton Welfare v Madeley | Shelton Welfare Cricket Club Ground, Stoke-on-Trent | Results |
| 11 Jun 1921 | | Burslem High Lane v Betley | Burslem High Lane Cricket Club Ground, Burslem | Results |
| 11 Jun 1921 | | Haslington v Nantwich | Clay Lane, Haslington | Results |
| 11 Jun 1921 | | Madeley v Great Chell | Park Street, Madeley | Results |
| 11 Jun 1921 | | North Staffordshire Railway v Shelton Welfare | not known | Results |
| 11 Jun 1921 | | Sandyford v Kidsgrove | Shelford Road, Sandyford | Results |
| 18 Jun 1921 | | Betley v Haslington | Marl Pit, Betley | Results |
| 18 Jun 1921 | | Great Chell v North Staffordshire Railway | Great Chell Cricket Club Ground, Great Chell | Results |
| 18 Jun 1921 | | Kidsgrove v Burslem High Lane | Kinnersley Ground, Kidsgrove | Results |
| 18 Jun 1921 | | Nantwich v Madeley | Kingsley Fields, Nantwich | Results |
| 18 Jun 1921 | | Shelton Welfare v Sandyford | Shelton Welfare Cricket Club Ground, Stoke-on-Trent | Results |
| 25 Jun 1921 | | Great Chell v Sandyford | Great Chell Cricket Club Ground, Great Chell | Results |
| 25 Jun 1921 | | Kidsgrove v Haslington | Kinnersley Ground, Kidsgrove | Results |
| 25 Jun 1921 | | Madeley v North Staffordshire Railway | Park Street, Madeley | Results |
| 25 Jun 1921 | | Nantwich v Betley | Kingsley Fields, Nantwich | Results |
| 25 Jun 1921 | | Shelton Welfare v Burslem High Lane | Shelton Welfare Cricket Club Ground, Stoke-on-Trent | Results |
| 02 Jul 1921 | | Betley v Kidsgrove | Marl Pit, Betley | Results |
| 02 Jul 1921 | | Burslem High Lane v Great Chell | Burslem High Lane Cricket Club Ground, Burslem | Results |
| 02 Jul 1921 | | Haslington v Shelton Welfare | Clay Lane, Haslington | Results |
| 02 Jul 1921 | | North Staffordshire Railway v Nantwich | not known | Results |
| 02 Jul 1921 | | Sandyford v Madeley | Shelford Road, Sandyford | Results |
| 09 Jul 1921 | | Great Chell v Haslington | Great Chell Cricket Club Ground, Great Chell | Results |
| 09 Jul 1921 | | Madeley v Burslem High Lane | Park Street, Madeley | Results |
| 09 Jul 1921 | | North Staffordshire Railway v Sandyford | not known | Results |
| 09 Jul 1921 | | Nantwich v Kidsgrove | Kingsley Fields, Nantwich | Results |
| 09 Jul 1921 | | Shelton Welfare v Betley | Shelton Welfare Cricket Club Ground, Stoke-on-Trent | Results |
| 16 Jul 1921 | | Betley v Great Chell | Marl Pit, Betley | Results |
| 16 Jul 1921 | | Burslem High Lane v North Staffordshire Railway | Burslem High Lane Cricket Club Ground, Burslem | Results |
| 16 Jul 1921 | | Haslington v Madeley | Clay Lane, Haslington | Results |
| 16 Jul 1921 | | Kidsgrove v Shelton Welfare | Kinnersley Ground, Kidsgrove | Results |
| 16 Jul 1921 | | Sandyford v Nantwich | Shelford Road, Sandyford | Results |
| 23 Jul 1921 | | Great Chell v Kidsgrove | Great Chell Cricket Club Ground, Great Chell | Results |
| 23 Jul 1921 | | Madeley v Betley | Park Street, Madeley | Results |
| 23 Jul 1921 | | North Staffordshire Railway v Haslington | not known | Results |
| 23 Jul 1921 | | Nantwich v Shelton Welfare | Kingsley Fields, Nantwich | Results |
| 23 Jul 1921 | | Sandyford v Burslem High Lane | Shelford Road, Sandyford | Results |
| 30 Jul 1921 | | Betley v North Staffordshire Railway | Marl Pit, Betley | Results |
| 30 Jul 1921 | | Burslem High Lane v Nantwich | Burslem High Lane Cricket Club Ground, Burslem | Results |
| 30 Jul 1921 | | Haslington v Sandyford | Clay Lane, Haslington | Results |
| 30 Jul 1921 | | Kidsgrove v Madeley | Kinnersley Ground, Kidsgrove | Results |
| 30 Jul 1921 | | Shelton Welfare v Great Chell | Shelton Welfare Cricket Club Ground, Stoke-on-Trent | Results |
| 13 Aug 1921 | | Burslem High Lane v Haslington | Burslem High Lane Cricket Club Ground, Burslem | Results |
| 13 Aug 1921 | | Madeley v Shelton Welfare | Park Street, Madeley | Results |
| 13 Aug 1921 | | North Staffordshire Railway v Kidsgrove | not known | Results |
| 13 Aug 1921 | | Nantwich v Great Chell | Kingsley Fields, Nantwich | Results |
| 13 Aug 1921 | | Sandyford v Betley | Shelford Road, Sandyford | Results |
| 20 Aug 1921 | | Betley v Burslem High Lane | Marl Pit, Betley | Results |
| 20 Aug 1921 | | Great Chell v Madeley | Great Chell Cricket Club Ground, Great Chell | Results |
| 20 Aug 1921 | | Kidsgrove v Sandyford | Kinnersley Ground, Kidsgrove | Results |
| 20 Aug 1921 | | Nantwich v Haslington | Kingsley Fields, Nantwich | Results |
| 20 Aug 1921 | | Shelton Welfare v North Staffordshire Railway | Shelton Welfare Cricket Club Ground, Stoke-on-Trent | Results |
| 27 Aug 1921 | | Burslem High Lane v Kidsgrove | Burslem High Lane Cricket Club Ground, Burslem | Results |
| 27 Aug 1921 | | Haslington v Betley | Clay Lane, Haslington | Results |
| 27 Aug 1921 | | Madeley v Nantwich | Park Street, Madeley | Results |
| 27 Aug 1921 | | North Staffordshire Railway v Great Chell | not known | Results |
| 27 Aug 1921 | | Sandyford v Shelton Welfare | Shelford Road, Sandyford | Results |
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