| 30 Apr 1921 | | Bignall End v Stone | Boon Hill Road, Bignall End | Results |
| 30 Apr 1921 | | Crewe Alexandra v Burslem | Alexandra Athletic Ground, Crewe | Results |
| 30 Apr 1921 | | Leek v Knypersley | Highfield, Leek | Results |
| 30 Apr 1921 | | Longton v Caverswall | Trentham Road, Stoke-on-Trent | Results |
| 30 Apr 1921 | | Norton v Silverdale | Community Drive, Smallthorne | Results |
| 30 Apr 1921 | | Porthill Park v Cheadle | Knutton Road, Wolstanton | Results |
| 07 May 1921 | | Burslem v Leek | Greyhound Way, Stoke-on-Trent | Results |
| 07 May 1921 | | Caverswall v Crewe Alexandra | Alan Gott Memorial Ground, Stoke-on-Trent | Results |
| 07 May 1921 | | Cheadle v Bignall End | Tean Road Sports Ground, Cheadle | Results |
| 07 May 1921 | | Knypersley v Norton | Tunstall Road, Knypersley | Results |
| 07 May 1921 | | Silverdale v Porthill Park | Underwood Road, Silverdale | Results |
| 07 May 1921 | | Stone v Longton | Lichfield Road, Stone | Results |
| 14 May 1921 | | Bignall End v Silverdale | Boon Hill Road, Bignall End | Results |
| 14 May 1921 | | Cheadle v Stone | Tean Road Sports Ground, Cheadle | Results |
| 14 May 1921 | | Crewe Alexandra v Longton | Alexandra Athletic Ground, Crewe | Results |
| 14 May 1921 | | Leek v Caverswall | Highfield, Leek | Results |
| 14 May 1921 | | Norton v Burslem | Community Drive, Smallthorne | Results |
| 14 May 1921 | | Porthill Park v Knypersley | Knutton Road, Wolstanton | Results |
| 16 May 1921 | | Burslem v Porthill Park | Greyhound Way, Stoke-on-Trent | Results |
| 16 May 1921 | | Caverswall v Norton | Alan Gott Memorial Ground, Stoke-on-Trent | Results |
| 16 May 1921 | | Knypersley v Bignall End | Tunstall Road, Knypersley | Results |
| 16 May 1921 | | Longton v Leek | Trentham Road, Stoke-on-Trent | Results |
| 16 May 1921 | | Silverdale v Cheadle | Underwood Road, Silverdale | Results |
| 16 May 1921 | | Stone v Crewe Alexandra | Lichfield Road, Stone | Results |
| 17 May 1921 | | Bignall End v Burslem | Boon Hill Road, Bignall End | Results |
| 17 May 1921 | | Cheadle v Knypersley | Tean Road Sports Ground, Cheadle | Results |
| 17 May 1921 | | Leek v Crewe Alexandra | Highfield, Leek | Results |
| 17 May 1921 | | Norton v Longton | Community Drive, Smallthorne | Results |
| 17 May 1921 | | Porthill Park v Caverswall | Knutton Road, Wolstanton | Results |
| 17 May 1921 | | Silverdale v Stone | Underwood Road, Silverdale | Results |
| 21 May 1921 | | Burslem v Cheadle | Greyhound Way, Stoke-on-Trent | Results |
| 21 May 1921 | | Caverswall v Bignall End | Alan Gott Memorial Ground, Stoke-on-Trent | Results |
| 21 May 1921 | | Crewe Alexandra v Norton | Alexandra Athletic Ground, Crewe | Results |
| 21 May 1921 | | Knypersley v Silverdale | Tunstall Road, Knypersley | Results |
| 21 May 1921 | | Longton v Porthill Park | Trentham Road, Stoke-on-Trent | Results |
| 21 May 1921 | | Stone v Leek | Lichfield Road, Stone | Results |
| 28 May 1921 | | Bignall End v Longton | Boon Hill Road, Bignall End | Results |
| 28 May 1921 | | Cheadle v Caverswall | Tean Road Sports Ground, Cheadle | Results |
| 28 May 1921 | | Knypersley v Stone | Tunstall Road, Knypersley | Results |
| 28 May 1921 | | Norton v Leek | Community Drive, Smallthorne | Results |
| 28 May 1921 | | Porthill Park v Crewe Alexandra | Knutton Road, Wolstanton | Results |
| 28 May 1921 | | Silverdale v Burslem | Underwood Road, Silverdale | Results |
| 04 Jun 1921 | | Burslem v Knypersley | Greyhound Way, Stoke-on-Trent | Results |
| 04 Jun 1921 | | Caverswall v Silverdale | Alan Gott Memorial Ground, Stoke-on-Trent | Results |
| 04 Jun 1921 | | Crewe Alexandra v Bignall End | Alexandra Athletic Ground, Crewe | Results |
| 04 Jun 1921 | | Leek v Porthill Park | Highfield, Leek | Results |
| 04 Jun 1921 | | Longton v Cheadle | Trentham Road, Stoke-on-Trent | Results |
| 04 Jun 1921 | | Norton v Stone | Community Drive, Smallthorne | Results |
| 11 Jun 1921 | | Bignall End v Leek | Boon Hill Road, Bignall End | Results |
| 11 Jun 1921 | | Cheadle v Crewe Alexandra | Tean Road Sports Ground, Cheadle | Results |
| 11 Jun 1921 | | Knypersley v Caverswall | Tunstall Road, Knypersley | Results |
| 11 Jun 1921 | | Porthill Park v Norton | Knutton Road, Wolstanton | Results |
| 11 Jun 1921 | | Silverdale v Longton | Underwood Road, Silverdale | Results |
| 11 Jun 1921 | | Stone v Burslem | Lichfield Road, Stone | Results |
| 18 Jun 1921 | | Bignall End v Porthill Park | Boon Hill Road, Bignall End | Results |
| 18 Jun 1921 | | Burslem v Longton | Greyhound Way, Stoke-on-Trent | Results |
| 18 Jun 1921 | | Cheadle v Norton | Tean Road Sports Ground, Cheadle | Results |
| 18 Jun 1921 | | Knypersley v Crewe Alexandra | Tunstall Road, Knypersley | Results |
| 18 Jun 1921 | | Silverdale v Leek | Underwood Road, Silverdale | Results |
| 18 Jun 1921 | | Stone v Caverswall | Lichfield Road, Stone | Results |
| 25 Jun 1921 | | Caverswall v Burslem | Alan Gott Memorial Ground, Stoke-on-Trent | Results |
| 25 Jun 1921 | | Crewe Alexandra v Silverdale | Alexandra Athletic Ground, Crewe | Results |
| 25 Jun 1921 | | Leek v Cheadle | Highfield, Leek | Results |
| 25 Jun 1921 | | Longton v Knypersley | Trentham Road, Stoke-on-Trent | Results |
| 25 Jun 1921 | | Norton v Bignall End | Community Drive, Smallthorne | Results |
| 25 Jun 1921 | | Porthill Park v Stone | Knutton Road, Wolstanton | Results |
| 02 Jul 1921 | | Burslem v Crewe Alexandra | Greyhound Way, Stoke-on-Trent | Results |
| 02 Jul 1921 | | Caverswall v Longton | Alan Gott Memorial Ground, Stoke-on-Trent | Results |
| 02 Jul 1921 | | Cheadle v Porthill Park | Tean Road Sports Ground, Cheadle | Results |
| 02 Jul 1921 | | Knypersley v Leek | Tunstall Road, Knypersley | Results |
| 02 Jul 1921 | | Silverdale v Norton | Underwood Road, Silverdale | Results |
| 02 Jul 1921 | | Stone v Bignall End | Lichfield Road, Stone | Results |
| 09 Jul 1921 | | Bignall End v Cheadle | Boon Hill Road, Bignall End | Results |
| 09 Jul 1921 | | Crewe Alexandra v Caverswall | Alexandra Athletic Ground, Crewe | Results |
| 09 Jul 1921 | | Leek v Burslem | Highfield, Leek | Results |
| 09 Jul 1921 | | Longton v Stone | Trentham Road, Stoke-on-Trent | Results |
| 09 Jul 1921 | | Norton v Knypersley | Community Drive, Smallthorne | Results |
| 09 Jul 1921 | | Porthill Park v Silverdale | Knutton Road, Wolstanton | Results |
| 16 Jul 1921 | | Burslem v Norton | Greyhound Way, Stoke-on-Trent | Results |
| 16 Jul 1921 | | Caverswall v Leek | Alan Gott Memorial Ground, Stoke-on-Trent | Results |
| 16 Jul 1921 | | Knypersley v Porthill Park | Tunstall Road, Knypersley | Results |
| 16 Jul 1921 | | Longton v Crewe Alexandra | Trentham Road, Stoke-on-Trent | Results |
| 16 Jul 1921 | | Silverdale v Bignall End | Underwood Road, Silverdale | Results |
| 16 Jul 1921 | | Stone v Cheadle | Lichfield Road, Stone | Results |
| 23 Jul 1921 | | Bignall End v Knypersley | Boon Hill Road, Bignall End | Results |
| 23 Jul 1921 | | Cheadle v Silverdale | Tean Road Sports Ground, Cheadle | Results |
| 23 Jul 1921 | | Crewe Alexandra v Stone | Alexandra Athletic Ground, Crewe | Results |
| 23 Jul 1921 | | Leek v Longton | Highfield, Leek | Results |
| 23 Jul 1921 | | Norton v Caverswall | Community Drive, Smallthorne | Results |
| 23 Jul 1921 | | Porthill Park v Burslem | Knutton Road, Wolstanton | Results |
| 30 Jul 1921 | | Burslem v Bignall End | Greyhound Way, Stoke-on-Trent | Results |
| 30 Jul 1921 | | Caverswall v Porthill Park | Alan Gott Memorial Ground, Stoke-on-Trent | Results |
| 30 Jul 1921 | | Crewe Alexandra v Leek | Alexandra Athletic Ground, Crewe | Results |
| 30 Jul 1921 | | Knypersley v Cheadle | Tunstall Road, Knypersley | Results |
| 30 Jul 1921 | | Longton v Norton | Trentham Road, Stoke-on-Trent | Results |
| 30 Jul 1921 | | Stone v Silverdale | Lichfield Road, Stone | Results |
| 06 Aug 1921 | | Bignall End v Caverswall | Boon Hill Road, Bignall End | Results |
| 06 Aug 1921 | | Cheadle v Burslem | Tean Road Sports Ground, Cheadle | Results |
| 06 Aug 1921 | | Leek v Stone | Highfield, Leek | Results |
| 06 Aug 1921 | | Norton v Crewe Alexandra | Community Drive, Smallthorne | Results |
| 06 Aug 1921 | | Porthill Park v Longton | Knutton Road, Wolstanton | Results |
| 06 Aug 1921 | | Silverdale v Knypersley | Underwood Road, Silverdale | Results |
| 13 Aug 1921 | | Burslem v Silverdale | Greyhound Way, Stoke-on-Trent | Results |
| 13 Aug 1921 | | Caverswall v Cheadle | Alan Gott Memorial Ground, Stoke-on-Trent | Results |
| 13 Aug 1921 | | Crewe Alexandra v Porthill Park | Alexandra Athletic Ground, Crewe | Results |
| 13 Aug 1921 | | Leek v Norton | Highfield, Leek | Results |
| 13 Aug 1921 | | Longton v Bignall End | Trentham Road, Stoke-on-Trent | Results |
| 13 Aug 1921 | | Stone v Knypersley | Lichfield Road, Stone | Results |
| 20 Aug 1921 | | Bignall End v Crewe Alexandra | Boon Hill Road, Bignall End | Results |
| 20 Aug 1921 | | Cheadle v Longton | Tean Road Sports Ground, Cheadle | Results |
| 20 Aug 1921 | | Knypersley v Burslem | Tunstall Road, Knypersley | Results |
| 20 Aug 1921 | | Porthill Park v Leek | Knutton Road, Wolstanton | Results |
| 20 Aug 1921 | | Silverdale v Caverswall | Underwood Road, Silverdale | Results |
| 20 Aug 1921 | | Stone v Norton | Lichfield Road, Stone | Results |
| 27 Aug 1921 | | Burslem v Stone | Greyhound Way, Stoke-on-Trent | Results |
| 27 Aug 1921 | | Caverswall v Knypersley | Alan Gott Memorial Ground, Stoke-on-Trent | Results |
| 27 Aug 1921 | | Crewe Alexandra v Cheadle | Alexandra Athletic Ground, Crewe | Results |
| 27 Aug 1921 | | Leek v Bignall End | Highfield, Leek | Results |
| 27 Aug 1921 | | Longton v Silverdale | Trentham Road, Stoke-on-Trent | Results |
| 27 Aug 1921 | | Norton v Porthill Park | Community Drive, Smallthorne | Results |
| 03 Sep 1921 | | Caverswall v Stone | Alan Gott Memorial Ground, Stoke-on-Trent | Results |
| 03 Sep 1921 | | Crewe Alexandra v Knypersley | Alexandra Athletic Ground, Crewe | Results |
| 03 Sep 1921 | | Leek v Silverdale | Highfield, Leek | Results |
| 03 Sep 1921 | | Longton v Burslem | Trentham Road, Stoke-on-Trent | Results |
| 03 Sep 1921 | | Norton v Cheadle | Community Drive, Smallthorne | Results |
| 03 Sep 1921 | | Porthill Park v Bignall End | Knutton Road, Wolstanton | Results |
| 10 Sep 1921 | | Bignall End v Norton | Boon Hill Road, Bignall End | Results |
| 10 Sep 1921 | | Burslem v Caverswall | Greyhound Way, Stoke-on-Trent | Results |
| 10 Sep 1921 | | Cheadle v Leek | Tean Road Sports Ground, Cheadle | Results |
| 10 Sep 1921 | | Knypersley v Longton | Tunstall Road, Knypersley | Results |
| 10 Sep 1921 | | Silverdale v Crewe Alexandra | Underwood Road, Silverdale | Results |
| 10 Sep 1921 | | Stone v Porthill Park | Lichfield Road, Stone | Results |
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