| 23 Apr 1921 | | Stalybridge v Levenshulme | Oxford Street, Stalybridge | Results |
| 23 Apr 1921 | | Ashton-under-Lyne v Gorton | Ashton Club Ground, Ashton-under-Lyne | Results |
| 30 Apr 1921 | | Dukinfield v Cheetham | Higher King Street, Dukinfield | Results |
| 30 Apr 1921 | | Prestwich v Ashton-under-Lyne | The Heys, Prestwich | Results |
| 30 Apr 1921 | | Stand v Longsight | Hamilton Road, Whitefield | Results |
| 30 Apr 1921 | | Levenshulme v Glossop | Levenshulme | Results |
| 07 May 1921 | | Cheetham v Glossop | Cheetham Cricket Club Ground, Manchester | Results |
| 07 May 1921 | | Stalybridge v Prestwich | Oxford Street, Stalybridge | Results |
| 07 May 1921 | | Stand v Ashton-under-Lyne | Hamilton Road, Whitefield | Results |
| 07 May 1921 | | Gorton v Dukinfield | Gorton | Results |
| 14 May 1921 | | Dukinfield v Stand | Higher King Street, Dukinfield | Results |
| 14 May 1921 | | Stalybridge v Gorton | Oxford Street, Stalybridge | Results |
| 14 May 1921 | | Cheetham v Levenshulme | Cheetham Cricket Club Ground, Manchester | Results |
| 14 May 1921 | | Prestwich v Longsight | The Heys, Prestwich | Results |
| 16 May 1921 | | Stand v Cheetham | Oxford Street, Stalybridge | Results |
| 18 May 1921 | | Levenshulme v Longsight | Levenshulme | Results |
| 20 May 1921 | | Ashton-under-Lyne v Glossop | Ashton Club Ground, Ashton-under-Lyne | Results |
| 20 May 1921 | | Stand v Levenshulme | Hamilton Road, Whitefield | Results |
| 20 May 1921 | | Dukinfield v Stalybridge | Higher King Street, Dukinfield | Results |
| 21 May 1921 | | Prestwich v Dukinfield | The Heys, Prestwich | Results |
| 21 May 1921 | | Glossop v Gorton | North Road, Glossop | Results |
| 21 May 1921 | | Longsight v Levenshulme | East Road, Longsight | Results |
| 21 May 1921 | | Ashton-under-Lyne v Cheetham | Ashton Club Ground, Ashton-under-Lyne | Results |
| 23 May 1921 | | Dukinfield v Lancashire and Cheshire Cricket League | Higher King Street, Dukinfield | Results |
| 28 May 1921 | | Stalybridge v Ashton-under-Lyne | Oxford Street, Stalybridge | Results |
| 28 May 1921 | | Cheetham v Dukinfield | Cheetham Cricket Club Ground, Manchester | Results |
| 28 May 1921 | | Prestwich v Glossop | The Heys, Prestwich | Results |
| 28 May 1921 | | Gorton v Longsight | Gorton | Results |
| 04 Jun 1921 | | Glossop v Levenshulme | North Road, Glossop | Results |
| 04 Jun 1921 | | Ashton-under-Lyne v Dukinfield | Ashton Club Ground, Ashton-under-Lyne | Results |
| 04 Jun 1921 | | Longsight v Cheetham | East Road, Longsight | Results |
| 04 Jun 1921 | | Stand v Stalybridge | Hamilton Road, Whitefield | Results |
| 04 Jun 1921 | | Gorton v Prestwich | Gorton | Results |
| 11 Jun 1921 | | Ashton-under-Lyne v Longsight | Ashton Club Ground, Ashton-under-Lyne | Results |
| 11 Jun 1921 | | Stalybridge v Glossop | Oxford Street, Stalybridge | Results |
| 11 Jun 1921 | | Prestwich v Levenshulme | The Heys, Prestwich | Results |
| 11 Jun 1921 | | Gorton v Stand | Gorton | Results |
| 18 Jun 1921 | | Cheetham v Ashton-under-Lyne | Cheetham Cricket Club Ground, Manchester | Results |
| 18 Jun 1921 | | Longsight v Gorton | East Road, Longsight | Results |
| 18 Jun 1921 | | Dukinfield v Glossop | Higher King Street, Dukinfield | Results |
| 18 Jun 1921 | | Stand v Prestwich | Hamilton Road, Whitefield | Results |
| 25 Jun 1921 | | Stand v Dukinfield | Hamilton Road, Whitefield | Results |
| 25 Jun 1921 | | Ashton-under-Lyne v Levenshulme | Ashton Club Ground, Ashton-under-Lyne | Results |
| 25 Jun 1921 | | Glossop v Longsight | North Road, Glossop | Results |
| 25 Jun 1921 | | Gorton v Stalybridge | Gorton | Results |
| 02 Jul 1921 | | Cheetham v Prestwich | Cheetham Cricket Club Ground, Manchester | Results |
| 02 Jul 1921 | | Stalybridge v Longsight | Oxford Street, Stalybridge | Results |
| 02 Jul 1921 | | Dukinfield v Ashton-under-Lyne | Higher King Street, Dukinfield | Results |
| 02 Jul 1921 | | Stand v Levenshulme | Hamilton Road, Whitefield | Results |
| 09 Jul 1921 | | Longsight v Prestwich | East Road, Longsight | Results |
| 09 Jul 1921 | | Ashton-under-Lyne v Stand | Ashton Club Ground, Ashton-under-Lyne | Results |
| 09 Jul 1921 | | Stalybridge v Dukinfield | Oxford Street, Stalybridge | Results |
| 09 Jul 1921 | | Glossop v Cheetham | North Road, Glossop | Results |
| 16 Jul 1921 | | Prestwich v Stand | The Heys, Prestwich | Results |
| 16 Jul 1921 | | Cheetham v Longsight | Cheetham Cricket Club Ground, Manchester | Results |
| 16 Jul 1921 | | Glossop v Stalybridge | North Road, Glossop | Results |
| 16 Jul 1921 | | Gorton v Ashton-under-Lyne | Gorton | Results |
| 23 Jul 1921 | | Longsight v Glossop | East Road, Longsight | Results |
| 23 Jul 1921 | | Dukinfield v Prestwich | Higher King Street, Dukinfield | Results |
| 23 Jul 1921 | | Ashton-under-Lyne v Stalybridge | Ashton Club Ground, Ashton-under-Lyne | Results |
| 30 Jul 1921 | | Longsight v Stand | East Road, Longsight | Results |
| 30 Jul 1921 | | Gorton v Glossop | Gorton | Results |
| 30 Jul 1921 | | Levenshulme v Cheetham | Levenshulme | Results |
| 01 Aug 1921 | | Cheetham v Stand | Cheetham Cricket Club Ground, Manchester | Results |
| 06 Aug 1921 | | Dukinfield v Longsight | Higher King Street, Dukinfield | Results |
| 06 Aug 1921 | | Glossop v Prestwich | North Road, Glossop | Results |
| 06 Aug 1921 | | Gorton v Cheetham | Gorton | Results |
| 06 Aug 1921 | | Levenshulme v Stalybridge | Levenshulme | Results |
| 13 Aug 1921 | | Prestwich v Stalybridge | The Heys, Prestwich | Results |
| 13 Aug 1921 | | Glossop v Stand | North Road, Glossop | Results |
| 13 Aug 1921 | | Longsight v Ashton-under-Lyne | East Road, Longsight | Results |
| 13 Aug 1921 | | Dukinfield v Levenshulme | Higher King Street, Dukinfield | Results |
| 20 Aug 1921 | | Stand v Gorton | Hamilton Road, Whitefield | Results |
| 20 Aug 1921 | | Longsight v Stalybridge | East Road, Longsight | Results |
| 20 Aug 1921 | | Glossop v Ashton-under-Lyne | North Road, Glossop | Results |
| 20 Aug 1921 | | Prestwich v Cheetham | The Heys, Prestwich | Results |
| 27 Aug 1921 | | Stalybridge v Stand | Oxford Street, Stalybridge | Results |
| 27 Aug 1921 | | Ashton-under-Lyne v Prestwich | Ashton Club Ground, Ashton-under-Lyne | Results |
| 27 Aug 1921 | | Glossop v Dukinfield | North Road, Glossop | Results |
| 27 Aug 1921 | | Cheetham v Gorton | Cheetham Cricket Club Ground, Manchester | Results |
| 03 Sep 1921 | | Prestwich v Gorton | The Heys, Prestwich | Results |
| 03 Sep 1921 | | Stalybridge v Cheetham | Oxford Street, Stalybridge | Results |
| 03 Sep 1921 | | Longsight v Dukinfield | East Road, Longsight | Results |
| 03 Sep 1921 | | Levenshulme v Ashton-under-Lyne | Levenshulme | Results |
| 10 Sep 1921 | | Dukinfield v Gorton | Higher King Street, Dukinfield | Results |
| 10 Sep 1921 | | Stand v Glossop | Hamilton Road, Whitefield | Results |
| 10 Sep 1921 | | Levenshulme v Prestwich | Levenshulme | Results |
| 17 Sep 1921 | | Cheetham v Stalybridge | Cheetham Cricket Club Ground, Manchester | Results |
| 17 Sep 1921 | | Levenshulme v Dukinfield | Levenshulme | Results |
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