| 23 Apr 1910 | | Hope PSA v Cornbrook | Hope PSA Cricket Club Ground, Manchester | Results |
| 23 Apr 1910 | | Ashton Albion v Monton Sunday School | Ashton Club Ground, Ashton-under-Lyne | Results |
| 23 Apr 1910 | | North-East Manchester v East Levenshulme | Manchester | Results |
| 23 Apr 1910 | | Blackley Parish Church v Kirkmanshulme | Tweedle Hill Road, Blackley | Results |
| 23 Apr 1910 | | Reddish v Gorton | Reddish | Results |
| 30 Apr 1910 | | Monton Sunday School v Hope PSA | Monton Sunday School Cricket Club Ground, Monton | Results |
| 30 Apr 1910 | | East Levenshulme v Ashton Albion | Levenshulme | Results |
| 30 Apr 1910 | | Kirkmanshulme v North-East Manchester | Kirkmanshulme | Results |
| 30 Apr 1910 | | Gorton v Blackley Parish Church | Gorton | Results |
| 30 Apr 1910 | | Cornbrook v Reddish | Cornbrook | Results |
| 07 May 1910 | | Hope PSA v East Levenshulme | Hope PSA Cricket Club Ground, Manchester | Results |
| 07 May 1910 | | Ashton Albion v Kirkmanshulme | Ashton Club Ground, Ashton-under-Lyne | Results |
| 07 May 1910 | | North-East Manchester v Gorton | Manchester | Results |
| 07 May 1910 | | Blackley Parish Church v Reddish | Tweedle Hill Road, Blackley | Results |
| 07 May 1910 | | Monton Sunday School v Cornbrook | Monton Sunday School Cricket Club Ground, Monton | Results |
| 14 May 1910 | | Kirkmanshulme v Hope PSA | Kirkmanshulme | Results |
| 14 May 1910 | | Gorton v Ashton Albion | Gorton | Results |
| 14 May 1910 | | Reddish v North-East Manchester | Reddish | Results |
| 14 May 1910 | | Cornbrook v Blackley Parish Church | Cornbrook | Results |
| 14 May 1910 | | East Levenshulme v Monton Sunday School | Levenshulme | Results |
| 16 May 1910 | | Manchester and District Cricket League North v Manchester and District Cricket League South | not known | Results |
| 28 May 1910 | | Hope PSA v Gorton | Hope PSA Cricket Club Ground, Manchester | Results |
| 28 May 1910 | | Ashton Albion v Reddish | Ashton Club Ground, Ashton-under-Lyne | Results |
| 28 May 1910 | | North-East Manchester v Blackley Parish Church | Manchester | Results |
| 28 May 1910 | | Monton Sunday School v Kirkmanshulme | Monton Sunday School Cricket Club Ground, Monton | Results |
| 28 May 1910 | | East Levenshulme v Cornbrook | Levenshulme | Results |
| 04 Jun 1910 | | Reddish v Hope PSA | Reddish | Results |
| 04 Jun 1910 | | Blackley Parish Church v Ashton Albion | Tweedle Hill Road, Blackley | Results |
| 04 Jun 1910 | | North-East Manchester v Cornbrook | Manchester | Results |
| 04 Jun 1910 | | Gorton v Monton Sunday School | Gorton | Results |
| 04 Jun 1910 | | Kirkmanshulme v East Levenshulme | Kirkmanshulme | Results |
| 11 Jun 1910 | | Hope PSA v Blackley Parish Church | Hope PSA Cricket Club Ground, Manchester | Results |
| 11 Jun 1910 | | Ashton Albion v North-East Manchester | Ashton Club Ground, Ashton-under-Lyne | Results |
| 11 Jun 1910 | | Monton Sunday School v Reddish | Monton Sunday School Cricket Club Ground, Monton | Results |
| 11 Jun 1910 | | Cornbrook v Kirkmanshulme | Cornbrook | Results |
| 11 Jun 1910 | | East Levenshulme v Gorton | Levenshulme | Results |
| 18 Jun 1910 | | North-East Manchester v Hope PSA | Manchester | Results |
| 18 Jun 1910 | | Ashton Albion v Cornbrook | Ashton Club Ground, Ashton-under-Lyne | Results |
| 18 Jun 1910 | | Blackley Parish Church v Monton Sunday School | Tweedle Hill Road, Blackley | Results |
| 18 Jun 1910 | | Reddish v East Levenshulme | Reddish | Results |
| 18 Jun 1910 | | Gorton v Kirkmanshulme | Gorton | Results |
| 25 Jun 1910 | | Hope PSA v Ashton Albion | Hope PSA Cricket Club Ground, Manchester | Results |
| 25 Jun 1910 | | Monton Sunday School v North-East Manchester | Monton Sunday School Cricket Club Ground, Monton | Results |
| 25 Jun 1910 | | East Levenshulme v Blackley Parish Church | Levenshulme | Results |
| 25 Jun 1910 | | Kirkmanshulme v Reddish | Kirkmanshulme | Results |
| 25 Jun 1910 | | Cornbrook v Gorton | Cornbrook | Results |
| 02 Jul 1910 | | Cornbrook v Hope PSA | Cornbrook | Results |
| 02 Jul 1910 | | Monton Sunday School v Ashton Albion | Monton Sunday School Cricket Club Ground, Monton | Results |
| 02 Jul 1910 | | East Levenshulme v North-East Manchester | Levenshulme | Results |
| 02 Jul 1910 | | Kirkmanshulme v Blackley Parish Church | Kirkmanshulme | Results |
| 02 Jul 1910 | | Gorton v Reddish | Gorton | Results |
| 09 Jul 1910 | | Hope PSA v Monton Sunday School | Hope PSA Cricket Club Ground, Manchester | Results |
| 09 Jul 1910 | | Ashton Albion v East Levenshulme | Ashton Club Ground, Ashton-under-Lyne | Results |
| 09 Jul 1910 | | North-East Manchester v Kirkmanshulme | Manchester | Results |
| 09 Jul 1910 | | Blackley Parish Church v Gorton | Tweedle Hill Road, Blackley | Results |
| 09 Jul 1910 | | Reddish v Cornbrook | Reddish | Results |
| 16 Jul 1910 | | East Levenshulme v Hope PSA | Levenshulme | Results |
| 16 Jul 1910 | | Kirkmanshulme v Ashton Albion | Kirkmanshulme | Results |
| 16 Jul 1910 | | Gorton v North-East Manchester | Gorton | Results |
| 16 Jul 1910 | | Reddish v Blackley Parish Church | Reddish | Results |
| 16 Jul 1910 | | Cornbrook v Monton Sunday School | Cornbrook | Results |
| 23 Jul 1910 | | Hope PSA v Kirkmanshulme | Hope PSA Cricket Club Ground, Manchester | Results |
| 23 Jul 1910 | | Ashton Albion v Gorton | Ashton Club Ground, Ashton-under-Lyne | Results |
| 23 Jul 1910 | | North-East Manchester v Reddish | Manchester | Results |
| 23 Jul 1910 | | Blackley Parish Church v Cornbrook | Tweedle Hill Road, Blackley | Results |
| 23 Jul 1910 | | Monton Sunday School v East Levenshulme | Monton Sunday School Cricket Club Ground, Monton | Results |
| 30 Jul 1910 | | Gorton v Hope PSA | Gorton | Results |
| 30 Jul 1910 | | Reddish v Ashton Albion | Reddish | Results |
| 30 Jul 1910 | | Blackley Parish Church v North-East Manchester | Tweedle Hill Road, Blackley | Results |
| 30 Jul 1910 | | Kirkmanshulme v Monton Sunday School | Kirkmanshulme | Results |
| 30 Jul 1910 | | Cornbrook v East Levenshulme | Cornbrook | Results |
| 06 Aug 1910 | | Hope PSA v Reddish | Hope PSA Cricket Club Ground, Manchester | Results |
| 06 Aug 1910 | | Ashton Albion v Blackley Parish Church | Ashton Club Ground, Ashton-under-Lyne | Results |
| 06 Aug 1910 | | Cornbrook v North-East Manchester | Cornbrook | Results |
| 06 Aug 1910 | | Monton Sunday School v Gorton | Monton Sunday School Cricket Club Ground, Monton | Results |
| 06 Aug 1910 | | East Levenshulme v Kirkmanshulme | Levenshulme | Results |
| 10 Aug 1910 | | Manchester Club and Ground v Manchester and District Cricket League | GP Codie's Ground, Eccles | Results |
| 13 Aug 1910 | | Blackley Parish Church v Hope PSA | Tweedle Hill Road, Blackley | Results |
| 13 Aug 1910 | | North-East Manchester v Ashton Albion | Manchester | Results |
| 13 Aug 1910 | | Reddish v Monton Sunday School | Reddish | Results |
| 13 Aug 1910 | | Kirkmanshulme v Cornbrook | Kirkmanshulme | Results |
| 13 Aug 1910 | | Gorton v East Levenshulme | Gorton | Results |
| 20 Aug 1910 | | Hope PSA v North-East Manchester | Hope PSA Cricket Club Ground, Manchester | Results |
| 20 Aug 1910 | | Cornbrook v Ashton Albion | Cornbrook | Results |
| 20 Aug 1910 | | Monton Sunday School v Blackley Parish Church | Monton Sunday School Cricket Club Ground, Monton | Results |
| 20 Aug 1910 | | East Levenshulme v Reddish | Levenshulme | Results |
| 20 Aug 1910 | | Kirkmanshulme v Gorton | Kirkmanshulme | Results |
| 27 Aug 1910 | | Ashton Albion v Hope PSA | Ashton Club Ground, Ashton-under-Lyne | Results |
| 27 Aug 1910 | | North-East Manchester v Monton Sunday School | Manchester | Results |
| 27 Aug 1910 | | Blackley Parish Church v East Levenshulme | Tweedle Hill Road, Blackley | Results |
| 27 Aug 1910 | | Reddish v Kirkmanshulme | Reddish | Results |
| 27 Aug 1910 | | Gorton v Cornbrook | Gorton | Results |
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