| 06 Jun 2010 | | Astley and Tyldesley Third XI v Deane and Derby Third XI | Meanley Road, Astley | Results |
| 13 Jun 2010 | | Brooksbottom Third XI v Bolton Third XI | Rowlands Road, Summerseat | Results |
| 13 Jun 2010 | | Flixton Third XI v Swinton Moorside Third XI | Lawrence Road, Flixton | Results |
| 13 Jun 2010 | | Heywood Third XI v Stretford Third XI | The Crimble Ground, Heywood | Results |
| 13 Jun 2010 | | Winton Third XI v South West Manchester Third XI | Alder Forest Avenue, Winton | Results |
| 13 Jun 2010 | | Worsley Third XI v Whalley Range Third XI | Walkden Road, Worsley | Results |
| 27 Jun 2010 | | Brooksbottom Third XI v Flixton Third XI | Rowlands Road, Summerseat | Results |
| 27 Jun 2010 | | Deane and Derby Third XI v Bolton Third XI | Sunnyside Park, Bolton | Results |
| 04 Jul 2010 | | Bolton Third XI v Whalley Range Third XI | Green Lane, Bolton | Results |
| 04 Jul 2010 | | Brooksbottom Third XI v Deane and Derby Third XI | Rowlands Road, Summerseat | Results |
| 04 Jul 2010 | | Flixton Third XI v Heywood Third XI | Lawrence Road, Flixton | Results |
| 04 Jul 2010 | | South West Manchester Third XI v Astley and Tyldesley Third XI | Ellesmere Road, Chorlton-cum-Hardy | Results |
| 04 Jul 2010 | | Winton Third XI v Swinton Moorside Third XI | Alder Forest Avenue, Winton | Results |
| 04 Jul 2010 | | Worsley Third XI v Stretford Third XI | Walkden Road, Worsley | Results |
| 11 Jul 2010 | | Bolton Third XI v South West Manchester Third XI | Green Lane, Bolton | Results |
| 11 Jul 2010 | | Astley and Tyldesley Third XI v Stretford Third XI | Meanley Road, Astley | Results |
| 11 Jul 2010 | | Brooksbottom Third XI v Whalley Range Third XI | Rowlands Road, Summerseat | Results |
| 11 Jul 2010 | | Flixton Third XI v Deane and Derby Third XI | Lawrence Road, Flixton | Results |
| 11 Jul 2010 | | Winton Third XI v Heywood Third XI | Alder Forest Avenue, Winton | Results |
| 11 Jul 2010 | | Worsley Third XI v Swinton Moorside Third XI | Walkden Road, Worsley | Results |
| 18 Jul 2010 | | Whalley Range Third XI v Astley and Tyldesley Third XI | Kingsbrook Road, Whalley Range | Results |
| 25 Jul 2010 | | Bolton Third XI v Stretford Third XI | Green Lane, Bolton | Results |
| 25 Jul 2010 | | Deane and Derby Third XI v Whalley Range Third XI | Sunnyside Park, Bolton | Results |
| 25 Jul 2010 | | Winton Third XI v Flixton Third XI | Alder Forest Avenue, Winton | Results |
| 25 Jul 2010 | | Worsley Third XI v Heywood Third XI | Walkden Road, Worsley | Results |
| 01 Aug 2010 | | South West Manchester Third XI v Deane and Derby Third XI | Ellesmere Road, Chorlton-cum-Hardy | Results |
| 01 Aug 2010 | | Stretford Third XI v Brooksbottom Third XI | The Boundary, Stretford | Results |
| 01 Aug 2010 | | Whalley Range Third XI v Flixton Third XI | Kingsbrook Road, Whalley Range | Results |
| 08 Aug 2010 | | Heywood Third XI v Brooksbottom Third XI | The Crimble Ground, Heywood | Results |
| 08 Aug 2010 | | South West Manchester Third XI v Flixton Third XI | Ellesmere Road, Chorlton-cum-Hardy | Results |
| 08 Aug 2010 | | Stretford Third XI v Whalley Range Third XI | The Boundary, Stretford | Results |
| 08 Aug 2010 | | Swinton Moorside Third XI v Deane and Derby Third XI | Moorside Park, Swinton | Results |
| 08 Aug 2010 | | Winton Third XI v Bolton Third XI | Alder Forest Avenue, Winton | Results |
| 08 Aug 2010 | | Worsley Third XI v Astley and Tyldesley Third XI | Walkden Road, Worsley | Results |
| 15 Aug 2010 | | Astley and Tyldesley Third XI v Heywood Third XI | Meanley Road, Astley | Results |
| 15 Aug 2010 | | Brooksbottom Third XI v South West Manchester Third XI | Rowlands Road, Summerseat | Results |
| 15 Aug 2010 | | Worsley Third XI v Winton Third XI | Walkden Road, Worsley | Results |
| 22 Aug 2010 | | Bolton Third XI v Heywood Third XI | Green Lane, Bolton | Results |
| 22 Aug 2010 | | Astley and Tyldesley Third XI v Winton Third XI | Meanley Road, Astley | Results |
| 22 Aug 2010 | | Brooksbottom Third XI v Swinton Moorside Third XI | Rowlands Road, Summerseat | Results |
| 22 Aug 2010 | | Deane and Derby Third XI v Stretford Third XI | Sunnyside Park, Bolton | Results |
| 22 Aug 2010 | | Flixton Third XI v Worsley Third XI | Lawrence Road, Flixton | Results |
| 22 Aug 2010 | | South West Manchester Third XI v Whalley Range Third XI | Ellesmere Road, Chorlton-cum-Hardy | Results |
| 29 Aug 2010 | | Astley and Tyldesley Third XI v Flixton Third XI | Meanley Road, Astley | Results |
| 29 Aug 2010 | | Brooksbottom Third XI v Winton Third XI | Rowlands Road, Summerseat | Results |
| 29 Aug 2010 | | Deane and Derby Third XI v Heywood Third XI | Sunnyside Park, Bolton | Results |
| 29 Aug 2010 | | South West Manchester Third XI v Stretford Third XI | Ellesmere Road, Chorlton-cum-Hardy | Results |
| 29 Aug 2010 | | Whalley Range Third XI v Swinton Moorside Third XI | Kingsbrook Road, Whalley Range | Results |
| 29 Aug 2010 | | Bolton Third XI v Worsley Third XI | Green Lane, Bolton | Results |
| 30 Aug 2010 | | Swinton Moorside Third XI v Heywood Third XI | Moorside Park, Swinton | Results |
| 01 Sep 2010 | | Astley and Tyldesley Third XI v Swinton Moorside Third XI | Meanley Road, Astley | Results |
| 05 Sep 2010 | | Bolton Third XI v Astley and Tyldesley Third XI | Green Lane, Bolton | Results |
| 05 Sep 2010 | | Flixton Third XI v Stretford Third XI | Lawrence Road, Flixton | Results |
| 05 Sep 2010 | | Swinton Moorside Third XI v South West Manchester Third XI | Moorside Park, Swinton | Results |
| 05 Sep 2010 | | Whalley Range Third XI v Heywood Third XI | Kingsbrook Road, Whalley Range | Results |
| 05 Sep 2010 | | Winton Third XI v Deane and Derby Third XI | Alder Forest Avenue, Winton | Results |
| 05 Sep 2010 | | Worsley Third XI v Brooksbottom Third XI | Walkden Road, Worsley | Results |
| 12 Sep 2010 | | Bolton Third XI v Flixton Third XI | Green Lane, Bolton | Results |
| 12 Sep 2010 | | Brooksbottom Third XI v Astley and Tyldesley Third XI | Rowlands Road, Summerseat | Results |
| 12 Sep 2010 | | Deane and Derby Third XI v Worsley Third XI | Sunnyside Park, Bolton | Results |
| 12 Sep 2010 | | South West Manchester Third XI v Heywood Third XI | Ellesmere Road, Chorlton-cum-Hardy | Results |
| 12 Sep 2010 | | Stretford Third XI v Swinton Moorside Third XI | The Boundary, Stretford | Results |
| 12 Sep 2010 | | Whalley Range Third XI v Winton Third XI | Kingsbrook Road, Whalley Range | Results |
| 19 Sep 2010 | | South West Manchester Third XI v Worsley Third XI | Ellesmere Road, Chorlton-cum-Hardy | Results |
| 19 Sep 2010 | | Stretford Third XI v Winton Third XI | The Boundary, Stretford | Results |
| 19 Sep 2010 | | Swinton Moorside Third XI v Bolton Third XI | Moorside Park, Swinton | Results |
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