| 22 May 2010 | | Bury Second XI v Swinton Moorside Second XI | Radcliffe Road, Bury | Results |
| 22 May 2010 | | Euxton Second XI v Deane and Derby Second XI | Balshaw Park, Euxton | Results |
| 22 May 2010 | | Stretford Second XI v Wythenshawe Second XI | The Boundary, Stretford | Results |
| 22 May 2010 | | Winton Second XI v Hindley St Peters Second XI | Alder Forest Avenue, Winton | Results |
| 22 May 2010 | | Worsley Second XI v South West Manchester Second XI | Walkden Road, Worsley | Results |
| 29 May 2010 | | Deane and Derby Second XI v Stretford Second XI | Sunnyside Park, Bolton | Results |
| 29 May 2010 | | Hindley St Peters Second XI v Worsley Second XI | St Peters Recreation Ground, Hindley | Results |
| 29 May 2010 | | South West Manchester Second XI v Euxton Second XI | Ellesmere Road, Chorlton-cum-Hardy | Results |
| 29 May 2010 | | Swinton Moorside Second XI v Winton Second XI | Moorside Park, Swinton | Results |
| 29 May 2010 | | Wythenshawe Second XI v Bury Second XI | Longley Lane, Northenden | Results |
| 05 Jun 2010 | | Bury Second XI v Deane and Derby Second XI | Radcliffe Road, Bury | Results |
| 05 Jun 2010 | | Euxton Second XI v Stretford Second XI | Balshaw Park, Euxton | Results |
| 05 Jun 2010 | | South West Manchester Second XI v Hindley St Peters Second XI | Ellesmere Road, Chorlton-cum-Hardy | Results |
| 05 Jun 2010 | | Winton Second XI v Wythenshawe Second XI | Alder Forest Avenue, Winton | Results |
| 05 Jun 2010 | | Worsley Second XI v Swinton Moorside Second XI | Walkden Road, Worsley | Results |
| 12 Jun 2010 | | Deane and Derby Second XI v Winton Second XI | Sunnyside Park, Bolton | Results |
| 12 Jun 2010 | | Hindley St Peters Second XI v Euxton Second XI | St Peters Recreation Ground, Hindley | Results |
| 12 Jun 2010 | | Stretford Second XI v Bury Second XI | The Boundary, Stretford | Results |
| 12 Jun 2010 | | Swinton Moorside Second XI v South West Manchester Second XI | Moorside Park, Swinton | Results |
| 12 Jun 2010 | | Wythenshawe Second XI v Worsley Second XI | Longley Lane, Northenden | Results |
| 19 Jun 2010 | | Euxton Second XI v Bury Second XI | Balshaw Park, Euxton | Results |
| 19 Jun 2010 | | Hindley St Peters Second XI v Swinton Moorside Second XI | St Peters Recreation Ground, Hindley | Results |
| 19 Jun 2010 | | South West Manchester Second XI v Wythenshawe Second XI | Ellesmere Road, Chorlton-cum-Hardy | Results |
| 19 Jun 2010 | | Winton Second XI v Stretford Second XI | Alder Forest Avenue, Winton | Results |
| 19 Jun 2010 | | Worsley Second XI v Deane and Derby Second XI | Walkden Road, Worsley | Results |
| 26 Jun 2010 | | Stretford Second XI v Worsley Second XI | The Boundary, Stretford | Results |
| 26 Jun 2010 | | Bury Second XI v Winton Second XI | Radcliffe Road, Bury | Results |
| 26 Jun 2010 | | Deane and Derby Second XI v South West Manchester Second XI | Sunnyside Park, Bolton | Results |
| 26 Jun 2010 | | Swinton Moorside Second XI v Euxton Second XI | Moorside Park, Swinton | Results |
| 26 Jun 2010 | | Wythenshawe Second XI v Hindley St Peters Second XI | Longley Lane, Northenden | Results |
| 03 Jul 2010 | | Euxton Second XI v Winton Second XI | Balshaw Park, Euxton | Results |
| 03 Jul 2010 | | Hindley St Peters Second XI v Deane and Derby Second XI | St Peters Recreation Ground, Hindley | Results |
| 03 Jul 2010 | | South West Manchester Second XI v Stretford Second XI | Ellesmere Road, Chorlton-cum-Hardy | Results |
| 03 Jul 2010 | | Swinton Moorside Second XI v Wythenshawe Second XI | Moorside Park, Swinton | Results |
| 03 Jul 2010 | | Worsley Second XI v Bury Second XI | Walkden Road, Worsley | Results |
| 10 Jul 2010 | | Bury Second XI v South West Manchester Second XI | Radcliffe Road, Bury | Results |
| 10 Jul 2010 | | Deane and Derby Second XI v Swinton Moorside Second XI | Sunnyside Park, Bolton | Results |
| 10 Jul 2010 | | Euxton Second XI v Wythenshawe Second XI | Balshaw Park, Euxton | Results |
| 10 Jul 2010 | | Stretford Second XI v Hindley St Peters Second XI | The Boundary, Stretford | Results |
| 10 Jul 2010 | | Winton Second XI v Worsley Second XI | Alder Forest Avenue, Winton | Results |
| 17 Jul 2010 | | Hindley St Peters Second XI v Bury Second XI | St Peters Recreation Ground, Hindley | Results |
| 17 Jul 2010 | | South West Manchester Second XI v Winton Second XI | Ellesmere Road, Chorlton-cum-Hardy | Results |
| 17 Jul 2010 | | Swinton Moorside Second XI v Stretford Second XI | Moorside Park, Swinton | Results |
| 17 Jul 2010 | | Worsley Second XI v Euxton Second XI | Walkden Road, Worsley | Results |
| 17 Jul 2010 | | Wythenshawe Second XI v Deane and Derby Second XI | Longley Lane, Northenden | Results |
| 24 Jul 2010 | | Deane and Derby Second XI v Euxton Second XI | Sunnyside Park, Bolton | Results |
| 24 Jul 2010 | | Hindley St Peters Second XI v Winton Second XI | St Peters Recreation Ground, Hindley | Results |
| 24 Jul 2010 | | South West Manchester Second XI v Worsley Second XI | Ellesmere Road, Chorlton-cum-Hardy | Results |
| 24 Jul 2010 | | Swinton Moorside Second XI v Bury Second XI | Moorside Park, Swinton | Results |
| 24 Jul 2010 | | Wythenshawe Second XI v Stretford Second XI | Longley Lane, Northenden | Results |
| 31 Jul 2010 | | Bury Second XI v Wythenshawe Second XI | Radcliffe Road, Bury | Results |
| 31 Jul 2010 | | Euxton Second XI v South West Manchester Second XI | Balshaw Park, Euxton | Results |
| 31 Jul 2010 | | Stretford Second XI v Deane and Derby Second XI | The Boundary, Stretford | Results |
| 31 Jul 2010 | | Winton Second XI v Swinton Moorside Second XI | Alder Forest Avenue, Winton | Results |
| 31 Jul 2010 | | Worsley Second XI v Hindley St Peters Second XI | Walkden Road, Worsley | Results |
| 07 Aug 2010 | | Deane and Derby Second XI v Bury Second XI | Sunnyside Park, Bolton | Results |
| 07 Aug 2010 | | Hindley St Peters Second XI v South West Manchester Second XI | St Peters Recreation Ground, Hindley | Results |
| 07 Aug 2010 | | Stretford Second XI v Euxton Second XI | The Boundary, Stretford | Results |
| 07 Aug 2010 | | Swinton Moorside Second XI v Worsley Second XI | Moorside Park, Swinton | Results |
| 07 Aug 2010 | | Wythenshawe Second XI v Winton Second XI | Longley Lane, Northenden | Results |
| 14 Aug 2010 | | Bury Second XI v Stretford Second XI | Radcliffe Road, Bury | Results |
| 14 Aug 2010 | | Euxton Second XI v Hindley St Peters Second XI | Balshaw Park, Euxton | Results |
| 14 Aug 2010 | | South West Manchester Second XI v Swinton Moorside Second XI | Ellesmere Road, Chorlton-cum-Hardy | Results |
| 14 Aug 2010 | | Winton Second XI v Deane and Derby Second XI | Alder Forest Avenue, Winton | Results |
| 14 Aug 2010 | | Worsley Second XI v Wythenshawe Second XI | Walkden Road, Worsley | Results |
| 21 Aug 2010 | | Bury Second XI v Euxton Second XI | Radcliffe Road, Bury | Results |
| 21 Aug 2010 | | Deane and Derby Second XI v Worsley Second XI | Sunnyside Park, Bolton | Results |
| 21 Aug 2010 | | Stretford Second XI v Winton Second XI | The Boundary, Stretford | Results |
| 21 Aug 2010 | | Swinton Moorside Second XI v Hindley St Peters Second XI | Moorside Park, Swinton | Results |
| 21 Aug 2010 | | Wythenshawe Second XI v South West Manchester Second XI | Longley Lane, Northenden | Results |
| 28 Aug 2010 | | Euxton Second XI v Swinton Moorside Second XI | Balshaw Park, Euxton | Results |
| 28 Aug 2010 | | Hindley St Peters Second XI v Wythenshawe Second XI | St Peters Recreation Ground, Hindley | Results |
| 28 Aug 2010 | | South West Manchester Second XI v Deane and Derby Second XI | Ellesmere Road, Chorlton-cum-Hardy | Results |
| 28 Aug 2010 | | Winton Second XI v Bury Second XI | Alder Forest Avenue, Winton | Results |
| 28 Aug 2010 | | Worsley Second XI v Stretford Second XI | Walkden Road, Worsley | Results |
| 04 Sep 2010 | | Deane and Derby Second XI v Hindley St Peters Second XI | Sunnyside Park, Bolton | Results |
| 04 Sep 2010 | | Stretford Second XI v South West Manchester Second XI | The Boundary, Stretford | Results |
| 04 Sep 2010 | | Winton Second XI v Euxton Second XI | Alder Forest Avenue, Winton | Results |
| 04 Sep 2010 | | Wythenshawe Second XI v Swinton Moorside Second XI | Longley Lane, Northenden | Results |
| 04 Sep 2010 | | Bury Second XI v Worsley Second XI | Radcliffe Road, Bury | Results |
| 11 Sep 2010 | | South West Manchester Second XI v Bury Second XI | Ellesmere Road, Chorlton-cum-Hardy | Results |
| 11 Sep 2010 | | Swinton Moorside Second XI v Deane and Derby Second XI | Moorside Park, Swinton | Results |
| 11 Sep 2010 | | Worsley Second XI v Winton Second XI | Walkden Road, Worsley | Results |
| 11 Sep 2010 | | Wythenshawe Second XI v Euxton Second XI | Longley Lane, Northenden | Results |
| 11 Sep 2010 | | Hindley St Peters Second XI v Stretford Second XI | St Peters Recreation Ground, Hindley | Results |
| 18 Sep 2010 | | Bury Second XI v Hindley St Peters Second XI | Radcliffe Road, Bury | Results |
| 18 Sep 2010 | | Deane and Derby Second XI v Wythenshawe Second XI | Sunnyside Park, Bolton | Results |
| 18 Sep 2010 | | Euxton Second XI v Worsley Second XI | Balshaw Park, Euxton | Results |
| 18 Sep 2010 | | Stretford Second XI v Swinton Moorside Second XI | The Boundary, Stretford | Results |
| 18 Sep 2010 | | Winton Second XI v South West Manchester Second XI | Alder Forest Avenue, Winton | Results |
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