| 21 May 2006 | First Round | Southport Trinity v Darcy Lever | The Rookery, Southport | Results |
| 21 May 2006 | First Round | Wythenshawe v Kearsley | Longley Lane, Northenden | Results |
| 21 May 2006 | First Round | Walshaw v Little Lever | Sycamore Road, Tottington | Results |
| 21 May 2006 | First Round | Rainford v Ormskirk | Jubilee Recreation Ground, Rainford | Results |
| 21 May 2006 | First Round | Morecambe v Prestatyn | Woodhill Lane, Morecambe | Results |
| 21 May 2006 | First Round | Greenfield v Atherton | Ladhill Lane, Greenfield | Results |
| 21 May 2006 | First Round | Wallasey v Farnworth Social Circle | The Kevin McCullagh Oval, Wallasey | Results |
| 21 May 2006 | First Round | St Annes v Freckleton | Vernon Road, St Annes | Results |
| 21 May 2006 | First Round | Bootle v Flowery Field | Wadham Road, Bootle | Results |
| 21 May 2006 | First Round | Edenfield v Bolton | Gincroft Lane, Edenfield | Results |
| 21 May 2006 | First Round | Moorside v Northern | Turf Pit Lane, Moorside | Results |
| 21 May 2006 | First Round | Irlam v Clitheroe | Irlam Steel Recreation Ground, Irlam | Results |
| 21 May 2006 | First Round | Old Xaverians v Lytham | St Francis Xavier's College Ground, Woolton | Results |
| 21 May 2006 | First Round | Netherfield v Denton | Parkside Road, Kendal | Results |
| 21 May 2006 | First Round | Greenmount v Standish | Brandlesholme Road, Greenmount | Results |
| 21 May 2006 | First Round | Bamford Fieldhouse v Spring View | Hollin Lane, Bamford | Results |
| 21 May 2006 | First Round | Longridge v Thornton Cleveleys | George Newsham Memorial Cricket Ground, Longridge | Results |
| 21 May 2006 | First Round | Hollinwood v Blackpool | Lime Lane, Hollinwood | Results |
| 21 May 2006 | First Round | Stretford v Fulwood and Broughton | The Boundary, Stretford | Results |
| 21 May 2006 | First Round | Prestwich v Padiham | The Heys, Prestwich | Results |
| 21 May 2006 | First Round | Euxton v Denton St Lawrence | Balshaw Park, Euxton | Results |
| 21 May 2006 | First Round | Saddleworth v Shawclough Village | Well-i-Hole, Saddleworth | Results |
| 28 May 2006 | First Round | Darwen v Rapid | The Brookhouse Aerospace Birch Hall Cricket Ground, Darwen | Results |
| 11 Jun 2006 | Second Round | St Annes v Bootle | Vernon Road, St Annes | Results |
| 11 Jun 2006 | Second Round | Barnoldswick v Ormskirk | Victory Park, Barnoldswick | Results |
| 11 Jun 2006 | Second Round | Lytham v Huyton | Church Road, Lytham St Annes | Results |
| 18 Jun 2006 | Second Round | Standish v Netherfield | Green Lane, Standish | Results |
| 18 Jun 2006 | Second Round | Farnworth v Bamford Fieldhouse | Bridgeman Park, Farnworth | Results |
| 18 Jun 2006 | Second Round | Thornton Cleveleys v St John's | Illawalla, Thornton Cleveleys | Results |
| 18 Jun 2006 | Second Round | Hollinwood v Stretford | Lime Lane, Hollinwood | Results |
| 18 Jun 2006 | Second Round | Prestwich v Norley Hall | The Heys, Prestwich | Results |
| 18 Jun 2006 | Second Round | Denton St Lawrence v Saddleworth | Sycamore Park, Denton | Results |
| 18 Jun 2006 | Second Round | Hindley St Peters v Darwen | St Peters Recreation Ground, Hindley | Results |
| 18 Jun 2006 | Second Round | Morecambe v Atherton | Woodhill Lane, Morecambe | Results |
| 18 Jun 2006 | Second Round | Settle v Farnworth Social Circle | Marshfield, Settle | Results |
| 18 Jun 2006 | Second Round | Edenfield v Vernon Carus | Gincroft Lane, Edenfield | Results |
| 18 Jun 2006 | Second Round | Northern v Irlam | Moor Park, Great Crosby | Results |
| 18 Jun 2006 | Second Round | Darcy Lever v Walkden | The Levers, Darcy Lever | Results |
| 18 Jun 2006 | Second Round | Kearsley v Walshaw | Springfield Road, Kearsley | Results |
| 02 Jul 2006 | Third Round | Darwen v Denton St Lawrence | The Brookhouse Aerospace Birch Hall Cricket Ground, Darwen | Results |
| 09 Jul 2006 | Third Round | Walshaw v Walkden | Sycamore Road, Tottington | Results |
| 09 Jul 2006 | Third Round | Atherton v Ormskirk | Higham Park, Atherton | Results |
| 09 Jul 2006 | Third Round | Bootle v Settle | Wadham Road, Bootle | Results |
| 09 Jul 2006 | Third Round | Irlam v Vernon Carus | Irlam Steel Recreation Ground, Irlam | Results |
| 09 Jul 2006 | Third Round | Netherfield v Huyton | Parkside Road, Kendal | Results |
| 09 Jul 2006 | Third Round | Thornton Cleveleys v Farnworth | Illawalla, Thornton Cleveleys | Results |
| 09 Jul 2006 | Third Round | Prestwich v Stretford | The Heys, Prestwich | Results |
| 30 Jul 2006 | Quarter-Final | Walshaw v Ormskirk | Sycamore Road, Tottington | Results |
| 30 Jul 2006 | Quarter-Final | Bootle v Irlam | Wadham Road, Bootle | Results |
| 30 Jul 2006 | Quarter-Final | Huyton v Farnworth | Huyton Lane, Huyton | Results |
| 30 Jul 2006 | Quarter-Final | Prestwich v Darwen | The Heys, Prestwich | Results |
| 13 Aug 2006 | Semi-Final | Bootle v Ormskirk | Wadham Road, Bootle | Results |
| 13 Aug 2006 | Semi-Final | Darwen v Huyton | The Brookhouse Aerospace Birch Hall Cricket Ground, Darwen | Results |
| 03 Sep 2006 | Final | Bootle v Darwen | Emirates Old Trafford, Manchester | Results |
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