| 15 May 2005 | First Round | Darcy Lever v Vertex | The Levers, Darcy Lever | Results |
| 15 May 2005 | First Round | Wavertree v Leigh | Sandown Lane, Wavertree | Results |
| 15 May 2005 | First Round | Tonge v Northern | Castle Hill, Bolton | Results |
| 15 May 2005 | First Round | Walshaw v Settle | Sycamore Road, Tottington | Results |
| 15 May 2005 | First Round | Hindley St Peters v Horwich RMI | St Peters Recreation Ground, Hindley | Results |
| 15 May 2005 | First Round | Denton v Chorley | Egerton Street, Denton | Results |
| 15 May 2005 | First Round | Walkden v Norley Hall | The Oval, Walkden | Results |
| 15 May 2005 | First Round | Denton St Lawrence v Ribblesdale Wanderers | Sycamore Park, Denton | Results |
| 15 May 2005 | First Round | Penwortham v Darwen | Middleforth Green, Penwortham | Results |
| 15 May 2005 | First Round | Morecambe v Atherton | Woodhill Lane, Morecambe | Results |
| 15 May 2005 | First Round | Ormskirk v Dukinfield | Brook Lane, Ormskirk | Results |
| 15 May 2005 | First Round | Read v Greenmount | Whalley Road, Read | Results |
| 15 May 2005 | First Round | South West Manchester v Wallasey | Ellesmere Road, Chorlton-cum-Hardy | Results |
| 15 May 2005 | First Round | Stretford v Earby | The Boundary, Stretford | Results |
| 15 May 2005 | First Round | Moorfield v Castletown | Moorfield Road, Widnes | Results |
| 15 May 2005 | First Round | Vernon Carus v St John's | Factory Lane, Penwortham | Results |
| 15 May 2005 | First Round | Ainsdale v Barnoldswick | Liverpool Road, Ainsdale | Results |
| 15 May 2005 | First Round | Great Eccleston v Woodhouses | Hall Lane, Great Eccleston | Results |
| 15 May 2005 | First Round | Rainhill v Degham Hibbert | Rainhill Recreation Ground, Rainhill | Results |
| 05 Jun 2005 | Second Round | Fulwood and Broughton v Northern | Highfield, Broughton | Results |
| 05 Jun 2005 | Second Round | Stretford v Lytham | The Boundary, Stretford | Results |
| 05 Jun 2005 | Second Round | Morecambe v Darwen | Woodhill Lane, Morecambe | Results |
| 05 Jun 2005 | Second Round | Greenmount v Westhoughton | Brandlesholme Road, Greenmount | Results |
| 06 Jun 2005 | Second Round | Bootle v Darcy Lever | Wadham Road, Bootle | Results |
| 12 Jun 2005 | Second Round | Longridge v Leigh | George Newsham Memorial Cricket Ground, Longridge | Results |
| 12 Jun 2005 | Second Round | Dukinfield v Wythenshawe | Higher King Street, Dukinfield | Results |
| 12 Jun 2005 | Second Round | Wallasey v Prestwich | The Kevin McCullagh Oval, Wallasey | Results |
| 12 Jun 2005 | Second Round | Daisy Hill v Moorfield | St James Street, Daisy Hill | Results |
| 12 Jun 2005 | Second Round | Netherfield v St John's | Parkside Road, Kendal | Results |
| 12 Jun 2005 | Second Round | Woodhouses v Barnoldswick | Medlock Road, Woodhouses | Results |
| 12 Jun 2005 | Second Round | Rainhill v Elton | Rainhill Recreation Ground, Rainhill | Results |
| 12 Jun 2005 | Second Round | Hindley St Peters v Walshaw | St Peters Recreation Ground, Hindley | Results |
| 12 Jun 2005 | Second Round | Chorley v Fleetwood | Windsor Park, Chorley | Results |
| 12 Jun 2005 | Second Round | Swinton Moorside v Walkden | Moorside Park, Swinton | Results |
| 12 Jun 2005 | Second Round | Eagley v Denton St Lawrence | Blackburn Road, Dunscar | Results |
| 03 Jul 2005 | Third Round | Dukinfield v Greenmount | Higher King Street, Dukinfield | Results |
| 03 Jul 2005 | Third Round | Wallasey v Lytham | The Kevin McCullagh Oval, Wallasey | Results |
| 03 Jul 2005 | Third Round | Daisy Hill v Netherfield | St James Street, Daisy Hill | Results |
| 03 Jul 2005 | Third Round | Barnoldswick v Rainhill | Victory Park, Barnoldswick | Results |
| 03 Jul 2005 | Third Round | Bootle v Leigh | Wadham Road, Bootle | Results |
| 03 Jul 2005 | Third Round | Northern v Hindley St Peters | Moor Park, Great Crosby | Results |
| 03 Jul 2005 | Third Round | Fleetwood v Swinton Moorside | Broadwaters, Fleetwood | Results |
| 10 Jul 2005 | Third Round | Denton St Lawrence v Darwen | Sycamore Park, Denton | Results |
| 10 Jul 2005 | Quarter-Final | Rainhill v Netherfield | Rainhill Recreation Ground, Rainhill | Results |
| 17 Jul 2005 | Quarter-Final | Lytham v Greenmount | Church Road, Lytham St Annes | Results |
| 17 Jul 2005 | Quarter-Final | Northern v Bootle | Moor Park, Great Crosby | Results |
| 24 Jul 2005 | Quarter-Final | Darwen v Fleetwood | The Brookhouse Aerospace Birch Hall Cricket Ground, Darwen | Results |
| 31 Jul 2005 | Semi-Final | Bootle v Fleetwood | Wadham Road, Bootle | Results |
| 07 Aug 2005 | Semi-Final | Greenmount v Netherfield | Brandlesholme Road, Greenmount | Results |
| 04 Sep 2005 | Final | Bootle v Greenmount | Emirates Old Trafford, Manchester | Results |
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