| 08 May 2010 | | Ainsdale v Wavertree | Liverpool Road, Ainsdale | Results |
| 08 May 2010 | | Alder v St Helens | Alder Road, Liverpool | Results |
| 08 May 2010 | | Burscough v Caldy | School Lane, Burscough | Results |
| 08 May 2010 | | Moorfield v Parkfield Liscard | Moorfield Road, Widnes | Results |
| 08 May 2010 | | St Helens Recreation v Southport Trinity | The Oval, St Helens | Results |
| 08 May 2010 | | Sutton v Birkenhead St Mary's | New Street, Sutton | Results |
| 15 May 2010 | | Alder v Burscough | Alder Road, Liverpool | Results |
| 15 May 2010 | | Birkenhead St Mary's v Ainsdale | Ashville Road, Birkenhead Park | Results |
| 15 May 2010 | | Parkfield Liscard v Sutton | Pemberton's Meadow, Wallasey | Results |
| 15 May 2010 | | St Helens v Moorfield | Windleshaw Road, St Helens | Results |
| 15 May 2010 | | Southport Trinity v Caldy | The Rookery, Southport | Results |
| 15 May 2010 | | Wavertree v St Helens Recreation | Sandown Lane, Wavertree | Results |
| 22 May 2010 | | Ainsdale v Parkfield Liscard | Liverpool Road, Ainsdale | Results |
| 22 May 2010 | | Burscough v Southport Trinity | School Lane, Burscough | Results |
| 22 May 2010 | | Caldy v Wavertree | Paton Field, Caldy | Results |
| 22 May 2010 | | Moorfield v Alder | Moorfield Road, Widnes | Results |
| 22 May 2010 | | St Helens Recreation v Birkenhead St Mary's | The Oval, St Helens | Results |
| 22 May 2010 | | Sutton v St Helens | New Street, Sutton | Results |
| 29 May 2010 | | Alder v Sutton | Alder Road, Liverpool | Results |
| 29 May 2010 | | Birkenhead St Mary's v Caldy | Ashville Road, Birkenhead Park | Results |
| 29 May 2010 | | Moorfield v Burscough | Moorfield Road, Widnes | Results |
| 29 May 2010 | | Parkfield Liscard v St Helens Recreation | Pemberton's Meadow, Wallasey | Results |
| 29 May 2010 | | St Helens v Ainsdale | Windleshaw Road, St Helens | Results |
| 29 May 2010 | | Wavertree v Southport Trinity | Sandown Lane, Wavertree | Results |
| 31 May 2010 | | Ainsdale v Alder | Liverpool Road, Ainsdale | Results |
| 31 May 2010 | | Burscough v Wavertree | School Lane, Burscough | Results |
| 31 May 2010 | | Caldy v Parkfield Liscard | Paton Field, Caldy | Results |
| 31 May 2010 | | St Helens Recreation v St Helens | The Oval, St Helens | Results |
| 31 May 2010 | | Southport Trinity v Birkenhead St Mary's | The Rookery, Southport | Results |
| 31 May 2010 | | Sutton v Moorfield | New Street, Sutton | Results |
| 05 Jun 2010 | | Alder v St Helens Recreation | Alder Road, Liverpool | Results |
| 05 Jun 2010 | | Birkenhead St Mary's v Wavertree | Ashville Road, Birkenhead Park | Results |
| 05 Jun 2010 | | Moorfield v Ainsdale | Moorfield Road, Widnes | Results |
| 05 Jun 2010 | | Parkfield Liscard v Southport Trinity | Pemberton's Meadow, Wallasey | Results |
| 05 Jun 2010 | | St Helens v Caldy | Windleshaw Road, St Helens | Results |
| 05 Jun 2010 | | Sutton v Burscough | New Street, Sutton | Results |
| 12 Jun 2010 | | Ainsdale v Sutton | Liverpool Road, Ainsdale | Results |
| 12 Jun 2010 | | Birkenhead St Mary's v Burscough | Ashville Road, Birkenhead Park | Results |
| 12 Jun 2010 | | Caldy v Alder | Paton Field, Caldy | Results |
| 12 Jun 2010 | | St Helens Recreation v Moorfield | The Oval, St Helens | Results |
| 12 Jun 2010 | | Southport Trinity v St Helens | The Rookery, Southport | Results |
| 12 Jun 2010 | | Wavertree v Parkfield Liscard | Sandown Lane, Wavertree | Results |
| 19 Jun 2010 | | Alder v Southport Trinity | Alder Road, Liverpool | Results |
| 19 Jun 2010 | | Burscough v Ainsdale | School Lane, Burscough | Results |
| 19 Jun 2010 | | Moorfield v Caldy | Moorfield Road, Widnes | Results |
| 19 Jun 2010 | | Parkfield Liscard v Birkenhead St Mary's | Pemberton's Meadow, Wallasey | Results |
| 19 Jun 2010 | | St Helens v Wavertree | Windleshaw Road, St Helens | Results |
| 19 Jun 2010 | | Sutton v St Helens Recreation | New Street, Sutton | Results |
| 26 Jun 2010 | | Ainsdale v St Helens Recreation | Liverpool Road, Ainsdale | Results |
| 26 Jun 2010 | | Alder v Wavertree | Alder Road, Liverpool | Results |
| 26 Jun 2010 | | Burscough v Parkfield Liscard | School Lane, Burscough | Results |
| 26 Jun 2010 | | Moorfield v Southport Trinity | Moorfield Road, Widnes | Results |
| 26 Jun 2010 | | St Helens v Birkenhead St Mary's | Windleshaw Road, St Helens | Results |
| 26 Jun 2010 | | Sutton v Caldy | New Street, Sutton | Results |
| 03 Jul 2010 | | Birkenhead St Mary's v Alder | Ashville Road, Birkenhead Park | Results |
| 03 Jul 2010 | | Caldy v Ainsdale | Paton Field, Caldy | Results |
| 03 Jul 2010 | | Parkfield Liscard v St Helens | Pemberton's Meadow, Wallasey | Results |
| 03 Jul 2010 | | St Helens Recreation v Burscough | The Oval, St Helens | Results |
| 03 Jul 2010 | | Southport Trinity v Sutton | The Rookery, Southport | Results |
| 03 Jul 2010 | | Wavertree v Moorfield | Sandown Lane, Wavertree | Results |
| 10 Jul 2010 | | Ainsdale v Southport Trinity | Liverpool Road, Ainsdale | Results |
| 10 Jul 2010 | | Alder v Parkfield Liscard | Alder Road, Liverpool | Results |
| 10 Jul 2010 | | Burscough v St Helens | School Lane, Burscough | Results |
| 10 Jul 2010 | | Moorfield v Birkenhead St Mary's | Moorfield Road, Widnes | Results |
| 10 Jul 2010 | | St Helens Recreation v Caldy | The Oval, St Helens | Results |
| 10 Jul 2010 | | Sutton v Wavertree | New Street, Sutton | Results |
| 17 Jul 2010 | | Birkenhead St Mary's v Sutton | Ashville Road, Birkenhead Park | Results |
| 17 Jul 2010 | | Caldy v Burscough | Paton Field, Caldy | Results |
| 17 Jul 2010 | | Parkfield Liscard v Moorfield | Pemberton's Meadow, Wallasey | Results |
| 17 Jul 2010 | | St Helens v Alder | Windleshaw Road, St Helens | Results |
| 17 Jul 2010 | | Southport Trinity v St Helens Recreation | The Rookery, Southport | Results |
| 17 Jul 2010 | | Wavertree v Ainsdale | Sandown Lane, Wavertree | Results |
| 24 Jul 2010 | | Ainsdale v Birkenhead St Mary's | Liverpool Road, Ainsdale | Results |
| 24 Jul 2010 | | Burscough v Alder | School Lane, Burscough | Results |
| 24 Jul 2010 | | Caldy v Southport Trinity | Paton Field, Caldy | Results |
| 24 Jul 2010 | | Moorfield v St Helens | Moorfield Road, Widnes | Results |
| 24 Jul 2010 | | St Helens Recreation v Wavertree | The Oval, St Helens | Results |
| 24 Jul 2010 | | Sutton v Parkfield Liscard | New Street, Sutton | Results |
| 31 Jul 2010 | | Alder v Moorfield | Alder Road, Liverpool | Results |
| 31 Jul 2010 | | Birkenhead St Mary's v St Helens Recreation | Ashville Road, Birkenhead Park | Results |
| 31 Jul 2010 | | Parkfield Liscard v Ainsdale | Pemberton's Meadow, Wallasey | Results |
| 31 Jul 2010 | | St Helens v Sutton | Windleshaw Road, St Helens | Results |
| 31 Jul 2010 | | Southport Trinity v Burscough | The Rookery, Southport | Results |
| 31 Jul 2010 | | Wavertree v Caldy | Sandown Lane, Wavertree | Results |
| 07 Aug 2010 | | Ainsdale v St Helens | Liverpool Road, Ainsdale | Results |
| 07 Aug 2010 | | Burscough v Moorfield | School Lane, Burscough | Results |
| 07 Aug 2010 | | Caldy v Birkenhead St Mary's | Paton Field, Caldy | Results |
| 07 Aug 2010 | | St Helens Recreation v Parkfield Liscard | The Oval, St Helens | Results |
| 07 Aug 2010 | | Southport Trinity v Wavertree | The Rookery, Southport | Results |
| 07 Aug 2010 | | Sutton v Alder | New Street, Sutton | Results |
| 14 Aug 2010 | | Ainsdale v Moorfield | Liverpool Road, Ainsdale | Results |
| 14 Aug 2010 | | Burscough v Sutton | School Lane, Burscough | Results |
| 14 Aug 2010 | | Caldy v St Helens | Paton Field, Caldy | Results |
| 14 Aug 2010 | | St Helens Recreation v Alder | The Oval, St Helens | Results |
| 14 Aug 2010 | | Southport Trinity v Parkfield Liscard | The Rookery, Southport | Results |
| 14 Aug 2010 | | Wavertree v Birkenhead St Mary's | Sandown Lane, Wavertree | Results |
| 21 Aug 2010 | | Alder v Caldy | Alder Road, Liverpool | Results |
| 21 Aug 2010 | | Burscough v Birkenhead St Mary's | School Lane, Burscough | Results |
| 21 Aug 2010 | | Moorfield v St Helens Recreation | Moorfield Road, Widnes | Results |
| 21 Aug 2010 | | Parkfield Liscard v Wavertree | Pemberton's Meadow, Wallasey | Results |
| 21 Aug 2010 | | St Helens v Southport Trinity | Windleshaw Road, St Helens | Results |
| 21 Aug 2010 | | Sutton v Ainsdale | New Street, Sutton | Results |
| 28 Aug 2010 | | Ainsdale v Burscough | Liverpool Road, Ainsdale | Results |
| 28 Aug 2010 | | Birkenhead St Mary's v Parkfield Liscard | Ashville Road, Birkenhead Park | Results |
| 28 Aug 2010 | | Caldy v Moorfield | Paton Field, Caldy | Results |
| 28 Aug 2010 | | St Helens Recreation v Sutton | The Oval, St Helens | Results |
| 28 Aug 2010 | | Southport Trinity v Alder | The Rookery, Southport | Results |
| 28 Aug 2010 | | Wavertree v St Helens | Sandown Lane, Wavertree | Results |
| 30 Aug 2010 | | Alder v Ainsdale | Alder Road, Liverpool | Results |
| 30 Aug 2010 | | Birkenhead St Mary's v Southport Trinity | Ashville Road, Birkenhead Park | Results |
| 30 Aug 2010 | | Moorfield v Sutton | Moorfield Road, Widnes | Results |
| 30 Aug 2010 | | Parkfield Liscard v Caldy | Pemberton's Meadow, Wallasey | Results |
| 30 Aug 2010 | | St Helens v St Helens Recreation | Windleshaw Road, St Helens | Results |
| 30 Aug 2010 | | Wavertree v Burscough | Sandown Lane, Wavertree | Results |
| 04 Sep 2010 | | Birkenhead St Mary's v St Helens | Ashville Road, Birkenhead Park | Results |
| 04 Sep 2010 | | Caldy v Sutton | Paton Field, Caldy | Results |
| 04 Sep 2010 | | Parkfield Liscard v Burscough | Pemberton's Meadow, Wallasey | Results |
| 04 Sep 2010 | | St Helens Recreation v Ainsdale | The Oval, St Helens | Results |
| 04 Sep 2010 | | Southport Trinity v Moorfield | The Rookery, Southport | Results |
| 04 Sep 2010 | | Wavertree v Alder | Sandown Lane, Wavertree | Results |
| 11 Sep 2010 | | Ainsdale v Caldy | Liverpool Road, Ainsdale | Results |
| 11 Sep 2010 | | Alder v Birkenhead St Mary's | Alder Road, Liverpool | Results |
| 11 Sep 2010 | | Burscough v St Helens Recreation | School Lane, Burscough | Results |
| 11 Sep 2010 | | Moorfield v Wavertree | Moorfield Road, Widnes | Results |
| 11 Sep 2010 | | St Helens v Parkfield Liscard | Windleshaw Road, St Helens | Results |
| 11 Sep 2010 | | Sutton v Southport Trinity | New Street, Sutton | Results |
| 18 Sep 2010 | | Birkenhead St Mary's v Moorfield | Ashville Road, Birkenhead Park | Results |
| 18 Sep 2010 | | Caldy v St Helens Recreation | Paton Field, Caldy | Results |
| 18 Sep 2010 | | Parkfield Liscard v Alder | Pemberton's Meadow, Wallasey | Results |
| 18 Sep 2010 | | St Helens v Burscough | Windleshaw Road, St Helens | Results |
| 18 Sep 2010 | | Southport Trinity v Ainsdale | The Rookery, Southport | Results |
| 18 Sep 2010 | | Wavertree v Sutton | Sandown Lane, Wavertree | Results |
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