| 15 Apr 2012 | First Round | Lowerhouse v Read | The Brooks Foundation Ground, Lowerhouse | Results |
| 15 Apr 2012 | First Round | Ramsbottom v Ribblesdale Wanderers | Acre Bottom, Ramsbottom | Results |
| 21 Apr 2012 | First Round | Accrington v Gujarat | The iMEP Arena, Accrington | Results |
| 21 Apr 2012 | First Round | Westhoughton v Church | The Tyldesleys, Westhoughton | Results |
| 26 May 2012 | Second Round | Accrington v Lowerhouse | The iMEP Arena, Accrington | Results |
| 26 May 2012 | Second Round | Todmorden v Denton St Lawrence | Centre Vale, Todmorden | Results |
| 13 May 2012 | First Round | Littleborough v Northern | Hare Hill, Littleborough | Results |
| 22 Apr 2012 | First Round | Blackpool v Baxenden | Stanley Park, Blackpool | Results |
| 28 Apr 2012 | First Round | Accrington v Gujarat | The iMEP Arena, Accrington | Results |
| 29 Apr 2012 | First Round | Westhoughton v Church | The Tyldesleys, Westhoughton | Results |
| 06 May 2012 | First Round | Lytham v Chorley | Church Road, Lytham St Annes | Results |
| 06 May 2012 | First Round | Leigh v Vernon Carus | Beech Walk, Leigh | Results |
| 06 May 2012 | First Round | Ormskirk v BAC-EE Preston | Brook Lane, Ormskirk | Results |
| 07 May 2012 | First Round | Greenmount v Great Eccleston | Brandlesholme Road, Greenmount | Results |
| 07 May 2012 | First Round | Castletown v Heyside | King William's College, Castletown | Results |
| 13 May 2012 | First Round | Walshaw v Bootle | Sycamore Road, Tottington | Results |
| 13 May 2012 | First Round | Darcy Lever v Rochdale | The Levers, Darcy Lever | Results |
| 13 May 2012 | First Round | Bury v Farnworth Social Circle | Radcliffe Road, Bury | Results |
| 13 May 2012 | First Round | Old Xaverians v Shaw | St Francis Xavier's College Ground, Woolton | Results |
| 13 May 2012 | First Round | Norden v Winton | Woodhouse Lane, Norden | Results |
| 13 May 2012 | First Round | Prestwich v Netherfield | The Heys, Prestwich | Results |
| 13 May 2012 | First Round | Whalley v Leyland | Station Road, Whalley | Results |
| 13 May 2012 | First Round | Garstang v Uppermill | Riverside Sports Ground, Garstang | Results |
| 13 May 2012 | First Round | St Annes v Swinton Moorside | Vernon Road, St Annes | Results |
| 13 May 2012 | First Round | Heywood v Flixton | The Crimble Ground, Heywood | Results |
| 13 May 2012 | First Round | Bamford Fieldhouse v Woodhouses | Hollin Lane, Bamford | Results |
| 13 May 2012 | First Round | Hindley St Peters v Denton St Lawrence | St Peters Recreation Ground, Hindley | Results |
| 13 May 2012 | First Round | Penwortham v Barnoldswick | Middleforth Green, Penwortham | Results |
| 13 May 2012 | First Round | Astley Bridge v Blackrod | Sharples Park, Astley Bridge | Results |
| 13 May 2012 | First Round | Walkden v Horwich RMI | The Oval, Walkden | Results |
| 13 May 2012 | First Round | Saddleworth v Elton | Well-i-Hole, Saddleworth | Results |
| 13 May 2012 | First Round | Farnworth v Middleton | Bridgeman Park, Farnworth | Results |
| 13 May 2012 | Second Round | Blackpool v Denton West | Stanley Park, Blackpool | Results |
| 16 May 2012 | Second Round | Elton v Ramsbottom | Leigh Lane, Elton | Results |
| 18 May 2012 | Second Round | Greenmount v Middleton | Brandlesholme Road, Greenmount | Results |
| 27 May 2012 | Second Round | Bamford Fieldhouse v Heywood | Hollin Lane, Bamford | Results |
| 27 May 2012 | Second Round | Heyside v Chorley | Little Hey Street, Heyside | Results |
| 27 May 2012 | Second Round | Rochdale v Bootle | Redbrook, Rochdale | Results |
| 03 Jun 2012 | Second Round | Westhoughton v Norden | The Tyldesleys, Westhoughton | Results |
| 03 Jun 2012 | Second Round | Walkden v Ormskirk | The Oval, Walkden | Results |
| 03 Jun 2012 | Second Round | Glossop v Netherfield | North Road, Glossop | Results |
| 03 Jun 2012 | Second Round | Garstang v Leyland | Riverside Sports Ground, Garstang | Results |
| 03 Jun 2012 | Second Round | Whalley Range v St Annes | Kingsbrook Road, Whalley Range | Results |
| 03 Jun 2012 | Second Round | Blackrod v Barnoldswick | Vicarage Road, Blackrod | Results |
| 03 Jun 2012 | Second Round | Vernon Carus v Northern | Factory Lane, Penwortham | Results |
| 04 Jun 2012 | Second Round | Shaw v Farnworth Social Circle | Holebottom Clough, Shaw | Results |
| 10 Jun 2012 | Third Round | Greenmount v Blackpool | Brandlesholme Road, Greenmount | Results |
| 01 Jul 2012 | Third Round | Leyland v Whalley Range | The John Stanning Memorial Cricket Ground, Leyland | Results |
| 01 Jul 2012 | Third Round | Bamford Fieldhouse v Todmorden | Hollin Lane, Bamford | Results |
| 01 Jul 2012 | Third Round | Blackrod v Northern | Vicarage Road, Blackrod | Results |
| 01 Jul 2012 | Third Round | Ormskirk v Elton | Brook Lane, Ormskirk | Results |
| 01 Jul 2012 | Third Round | Heyside v Netherfield | Little Hey Street, Heyside | Results |
| 01 Jul 2012 | Third Round | Bootle v Lowerhouse | Wadham Road, Bootle | Results |
| 01 Jul 2012 | Third Round | Farnworth Social Circle v Norden | Piggott Park, Farnworth | Results |
| 22 Jul 2012 | Quarter-Final | Bamford Fieldhouse v Leyland | Hollin Lane, Bamford | Results |
| 22 Jul 2012 | Quarter-Final | Heyside v Ormskirk | Little Hey Street, Heyside | Results |
| 22 Jul 2012 | Quarter-Final | Norden v Bootle | Woodhouse Lane, Norden | Results |
| 29 Jul 2012 | Quarter-Final | Blackpool v Northern | Stanley Park, Blackpool | Results |
| 12 Aug 2012 | Semi-Final | Northern v Bootle | Moor Park, Great Crosby | Results |
| 26 Aug 2012 | Semi-Final | Heyside v Bamford Fieldhouse | Little Hey Street, Heyside | Results |
| 16 Sep 2012 | Final | Bamford Fieldhouse v Northern | Emirates Old Trafford, Manchester | Results |
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