| 24 May 1981 | First Round | Association of Kent Cricket Clubs v Middlesex Cricket Union | not known | Results |
| 24 May 1981 | First Round | Dorset Cricket Association v Isle of Wight Cricket Association | not known | Results |
| 24 May 1981 | First Round | Wiltshire Cricket Association v Hampshire Cricket Association | not known | Results |
| 24 May 1981 | First Round | Surrey Cricket Association v Sussex Cricket Association | New Malden Cricket Club Ground, New Malden | Results |
| 14 Jun 1981 | First Round | Warwickshire Cricket Association v Shropshire Cricket Association | Edgbaston Foundation Community Sports Ground, Birmingham | Results |
| 24 May 1981 | First Round | Gloucestershire Cricket Association v Worcestershire Cricket Association | Stinchcombe | Results |
| 24 May 1981 | First Round | Oxfordshire County Cricket Association v Herefordshire Cricket Association | not known | Results |
| 24 May 1981 | First Round | Essex Cricket Association v Northamptonshire Cricket Association | School Lane, Orsett | Results |
| 24 May 1981 | First Round | Huntingdonshire and Peterborough Cricket Association v Suffolk Cricket Association | not known | Results |
| 24 May 1981 | First Round | Cumbria Cricket Association v Northumberland Cricket Association | Vicars Croft, Appleby Eden | Results |
| 24 May 1981 | First Round | Yorkshire Cricket Association v Nottinghamshire Cricket Association | Cemetery Road, Heckmondwike | Results |
| 31 May 1981 | First Round | Yorkshire Cricket Association v Nottinghamshire Cricket Association | Town Fields, Doncaster | Results |
| 21 Jun 1981 | Second Round | not known v Middlesex Cricket Union | not known | Results |
| 21 Jun 1981 | Second Round | Sussex Cricket Association v Wiltshire Cricket Association | New County Ground, Hove | Results |
| 21 Jun 1981 | Second Round | Warwickshire Cricket Association v Worcestershire Cricket Association | Griff and Coton Ground, Nuneaton | Results |
| 21 Jun 1981 | Second Round | not known v Somerset Cricket Association | not known | Results |
| 21 Jun 1981 | Second Round | Essex Cricket Association v Derbyshire Cricket Association | not known | Results |
| 21 Jun 1981 | Second Round | Suffolk Cricket Association v Bedfordshire Association of Cricket Clubs | Framlingham College Ground, Framlingham | Results |
| 21 Jun 1981 | Second Round | Cumbria Cricket Association v Durham Cricket Association | not known | Results |
| 21 Jun 1981 | Second Round | Yorkshire Cricket Association v Lincolnshire and South Humberside Cricket Association | not known | Results |
| 12 Jul 1981 | Quarter-Final | Middlesex Cricket Union v Sussex Cricket Association | Cool Oak Lane, Hendon | Results |
| 12 Jul 1981 | Quarter-Final | Worcestershire Cricket Association v Somerset Cricket Association | War Memorial Ground, Amblecote | Results |
| 19 Jul 1981 | Quarter-Final | Essex Cricket Association v Suffolk Cricket Association | School Lane, Orsett | Results |
| 12 Jul 1981 | Quarter-Final | Durham Cricket Association v Yorkshire Cricket Association | not known | Results |
| 23 Aug 1981 | Semi-Final | Sussex Cricket Association v Worcestershire Cricket Association | Hurstpierpoint College Ground, Hurstpierpoint | Results |
| 03 Aug 1981 | Semi-Final | Essex Cricket Association v Yorkshire Cricket Association | School Lane, Orsett | Results |
| 07 Sep 1981 | Final | Sussex Cricket Association v Yorkshire Cricket Association | Visit Worcestershire New Road, Worcester | Results |
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