| 17 Apr 2010 | | Brooklands v Warrington | Brooklands Sports Club, Sale | Results |
| 17 Apr 2010 | | Tattenhall v Timperley | Flacca Field, Tattenhall | Results |
| 17 Apr 2010 | | Stockport Georgians v Ashton-on-Mersey | Cromley Road, Woodsmoor | Results |
| 17 Apr 2010 | | Bredbury St Marks v Congleton | Hillside Road, Woodley | Results |
| 17 Apr 2010 | | Mobberley v Sale | Church Lane, Mobberley | Results |
| 17 Apr 2010 | | Marple v Birkenhead Park | Bowden Lane, Marple | Results |
| 24 Apr 2010 | | Warrington v Bredbury St Marks | Walton Lea Road, Warrington | Results |
| 24 Apr 2010 | | Timperley v Brooklands | Stockport Road, Timperley | Results |
| 24 Apr 2010 | | Congleton v Marple | Booth Street, Congleton | Results |
| 24 Apr 2010 | | Birkenhead Park v Mobberley | Park Drive, Birkenhead | Results |
| 24 Apr 2010 | | Ashton-on-Mersey v Tattenhall | The Beets, Sale | Results |
| 24 Apr 2010 | | Sale v Stockport Georgians | Rookwood, Sale | Results |
| 01 May 2010 | | Brooklands v Bredbury St Marks | Brooklands Sports Club, Sale | Results |
| 01 May 2010 | | Mobberley v Congleton | Church Lane, Mobberley | Results |
| 01 May 2010 | | Stockport Georgians v Birkenhead Park | Cromley Road, Woodsmoor | Results |
| 01 May 2010 | | Marple v Warrington | Bowden Lane, Marple | Results |
| 01 May 2010 | | Timperley v Ashton-on-Mersey | Stockport Road, Timperley | Results |
| 01 May 2010 | | Tattenhall v Sale | Flacca Field, Tattenhall | Results |
| 08 May 2010 | | Warrington v Mobberley | Walton Lea Road, Warrington | Results |
| 08 May 2010 | | Congleton v Stockport Georgians | Booth Street, Congleton | Results |
| 08 May 2010 | | Sale v Timperley | Rookwood, Sale | Results |
| 08 May 2010 | | Birkenhead Park v Tattenhall | Park Drive, Birkenhead | Results |
| 08 May 2010 | | Bredbury St Marks v Marple | Hillside Road, Woodley | Results |
| 08 May 2010 | | Ashton-on-Mersey v Brooklands | The Beets, Sale | Results |
| 15 May 2010 | | Ashton-on-Mersey v Sale | The Beets, Sale | Results |
| 15 May 2010 | | Brooklands v Marple | Brooklands Sports Club, Sale | Results |
| 15 May 2010 | | Mobberley v Bredbury St Marks | Church Lane, Mobberley | Results |
| 15 May 2010 | | Timperley v Birkenhead Park | Stockport Road, Timperley | Results |
| 15 May 2010 | | Stockport Georgians v Warrington | Cromley Road, Woodsmoor | Results |
| 15 May 2010 | | Tattenhall v Congleton | Flacca Field, Tattenhall | Results |
| 22 May 2010 | | Warrington v Tattenhall | Walton Lea Road, Warrington | Results |
| 22 May 2010 | | Congleton v Timperley | Booth Street, Congleton | Results |
| 22 May 2010 | | Marple v Mobberley | Bowden Lane, Marple | Results |
| 22 May 2010 | | Sale v Brooklands | Rookwood, Sale | Results |
| 22 May 2010 | | Bredbury St Marks v Stockport Georgians | Hillside Road, Woodley | Results |
| 22 May 2010 | | Birkenhead Park v Ashton-on-Mersey | Park Drive, Birkenhead | Results |
| 29 May 2010 | | Ashton-on-Mersey v Congleton | The Beets, Sale | Results |
| 29 May 2010 | | Brooklands v Mobberley | Brooklands Sports Club, Sale | Results |
| 29 May 2010 | | Sale v Birkenhead Park | Rookwood, Sale | Results |
| 29 May 2010 | | Tattenhall v Bredbury St Marks | Flacca Field, Tattenhall | Results |
| 29 May 2010 | | Stockport Georgians v Marple | Cromley Road, Woodsmoor | Results |
| 29 May 2010 | | Timperley v Warrington | Stockport Road, Timperley | Results |
| 05 Jun 2010 | | Warrington v Ashton-on-Mersey | Walton Lea Road, Warrington | Results |
| 05 Jun 2010 | | Marple v Tattenhall | Bowden Lane, Marple | Results |
| 05 Jun 2010 | | Congleton v Sale | Booth Street, Congleton | Results |
| 05 Jun 2010 | | Mobberley v Stockport Georgians | Church Lane, Mobberley | Results |
| 05 Jun 2010 | | Bredbury St Marks v Timperley | Hillside Road, Woodley | Results |
| 05 Jun 2010 | | Birkenhead Park v Brooklands | Park Drive, Birkenhead | Results |
| 12 Jun 2010 | | Ashton-on-Mersey v Bredbury St Marks | The Beets, Sale | Results |
| 12 Jun 2010 | | Birkenhead Park v Congleton | Park Drive, Birkenhead | Results |
| 12 Jun 2010 | | Sale v Warrington | Rookwood, Sale | Results |
| 12 Jun 2010 | | Brooklands v Stockport Georgians | Brooklands Sports Club, Sale | Results |
| 12 Jun 2010 | | Tattenhall v Mobberley | Flacca Field, Tattenhall | Results |
| 12 Jun 2010 | | Timperley v Marple | Stockport Road, Timperley | Results |
| 19 Jun 2010 | | Stockport Georgians v Tattenhall | Cromley Road, Woodsmoor | Results |
| 19 Jun 2010 | | Warrington v Birkenhead Park | Walton Lea Road, Warrington | Results |
| 19 Jun 2010 | | Congleton v Brooklands | Booth Street, Congleton | Results |
| 19 Jun 2010 | | Marple v Ashton-on-Mersey | Bowden Lane, Marple | Results |
| 19 Jun 2010 | | Mobberley v Timperley | Church Lane, Mobberley | Results |
| 19 Jun 2010 | | Bredbury St Marks v Sale | Hillside Road, Woodley | Results |
| 26 Jun 2010 | | Ashton-on-Mersey v Mobberley | The Beets, Sale | Results |
| 26 Jun 2010 | | Birkenhead Park v Bredbury St Marks | Park Drive, Birkenhead | Results |
| 26 Jun 2010 | | Sale v Marple | Rookwood, Sale | Results |
| 26 Jun 2010 | | Congleton v Warrington | Booth Street, Congleton | Results |
| 26 Jun 2010 | | Brooklands v Tattenhall | Brooklands Sports Club, Sale | Results |
| 26 Jun 2010 | | Timperley v Stockport Georgians | Stockport Road, Timperley | Results |
| 03 Jul 2010 | | Warrington v Brooklands | Walton Lea Road, Warrington | Results |
| 03 Jul 2010 | | Timperley v Tattenhall | Stockport Road, Timperley | Results |
| 03 Jul 2010 | | Sale v Mobberley | Rookwood, Sale | Results |
| 03 Jul 2010 | | Congleton v Bredbury St Marks | Booth Street, Congleton | Results |
| 03 Jul 2010 | | Ashton-on-Mersey v Stockport Georgians | The Beets, Sale | Results |
| 03 Jul 2010 | | Birkenhead Park v Marple | Park Drive, Birkenhead | Results |
| 10 Jul 2010 | | Bredbury St Marks v Warrington | Hillside Road, Woodley | Results |
| 10 Jul 2010 | | Mobberley v Birkenhead Park | Church Lane, Mobberley | Results |
| 10 Jul 2010 | | Marple v Congleton | Bowden Lane, Marple | Results |
| 10 Jul 2010 | | Brooklands v Timperley | Brooklands Sports Club, Sale | Results |
| 10 Jul 2010 | | Stockport Georgians v Sale | Cromley Road, Woodsmoor | Results |
| 10 Jul 2010 | | Tattenhall v Ashton-on-Mersey | Flacca Field, Tattenhall | Results |
| 17 Jul 2010 | | Warrington v Marple | Walton Lea Road, Warrington | Results |
| 17 Jul 2010 | | Congleton v Mobberley | Booth Street, Congleton | Results |
| 17 Jul 2010 | | Sale v Tattenhall | Rookwood, Sale | Results |
| 17 Jul 2010 | | Ashton-on-Mersey v Timperley | The Beets, Sale | Results |
| 17 Jul 2010 | | Birkenhead Park v Stockport Georgians | Park Drive, Birkenhead | Results |
| 17 Jul 2010 | | Bredbury St Marks v Brooklands | Hillside Road, Woodley | Results |
| 24 Jul 2010 | | Brooklands v Ashton-on-Mersey | Brooklands Sports Club, Sale | Results |
| 24 Jul 2010 | | Marple v Bredbury St Marks | Bowden Lane, Marple | Results |
| 24 Jul 2010 | | Mobberley v Warrington | Church Lane, Mobberley | Results |
| 24 Jul 2010 | | Tattenhall v Birkenhead Park | Flacca Field, Tattenhall | Results |
| 24 Jul 2010 | | Stockport Georgians v Congleton | Cromley Road, Woodsmoor | Results |
| 24 Jul 2010 | | Timperley v Sale | Stockport Road, Timperley | Results |
| 31 Jul 2010 | | Warrington v Stockport Georgians | Walton Lea Road, Warrington | Results |
| 31 Jul 2010 | | Sale v Ashton-on-Mersey | Rookwood, Sale | Results |
| 31 Jul 2010 | | Congleton v Tattenhall | Booth Street, Congleton | Results |
| 31 Jul 2010 | | Marple v Brooklands | Bowden Lane, Marple | Results |
| 31 Jul 2010 | | Bredbury St Marks v Mobberley | Hillside Road, Woodley | Results |
| 31 Jul 2010 | | Birkenhead Park v Timperley | Park Drive, Birkenhead | Results |
| 07 Aug 2010 | | Ashton-on-Mersey v Birkenhead Park | The Beets, Sale | Results |
| 07 Aug 2010 | | Brooklands v Sale | Brooklands Sports Club, Sale | Results |
| 07 Aug 2010 | | Mobberley v Marple | Church Lane, Mobberley | Results |
| 07 Aug 2010 | | Timperley v Congleton | Stockport Road, Timperley | Results |
| 07 Aug 2010 | | Tattenhall v Warrington | Flacca Field, Tattenhall | Results |
| 07 Aug 2010 | | Stockport Georgians v Bredbury St Marks | Cromley Road, Woodsmoor | Results |
| 14 Aug 2010 | | Warrington v Timperley | Walton Lea Road, Warrington | Results |
| 14 Aug 2010 | | Mobberley v Brooklands | Church Lane, Mobberley | Results |
| 14 Aug 2010 | | Marple v Stockport Georgians | Bowden Lane, Marple | Results |
| 14 Aug 2010 | | Congleton v Ashton-on-Mersey | Booth Street, Congleton | Results |
| 14 Aug 2010 | | Bredbury St Marks v Tattenhall | Hillside Road, Woodley | Results |
| 14 Aug 2010 | | Birkenhead Park v Sale | Park Drive, Birkenhead | Results |
| 21 Aug 2010 | | Ashton-on-Mersey v Warrington | The Beets, Sale | Results |
| 21 Aug 2010 | | Brooklands v Birkenhead Park | Brooklands Sports Club, Sale | Results |
| 21 Aug 2010 | | Sale v Congleton | Rookwood, Sale | Results |
| 21 Aug 2010 | | Stockport Georgians v Mobberley | Cromley Road, Woodsmoor | Results |
| 21 Aug 2010 | | Tattenhall v Marple | Flacca Field, Tattenhall | Results |
| 21 Aug 2010 | | Timperley v Bredbury St Marks | Stockport Road, Timperley | Results |
| 28 Aug 2010 | | Warrington v Sale | Walton Lea Road, Warrington | Results |
| 28 Aug 2010 | | Stockport Georgians v Brooklands | Cromley Road, Woodsmoor | Results |
| 28 Aug 2010 | | Marple v Timperley | Bowden Lane, Marple | Results |
| 28 Aug 2010 | | Mobberley v Tattenhall | Church Lane, Mobberley | Results |
| 28 Aug 2010 | | Congleton v Birkenhead Park | Booth Street, Congleton | Results |
| 28 Aug 2010 | | Bredbury St Marks v Ashton-on-Mersey | Hillside Road, Woodley | Results |
| 04 Sep 2010 | | Birkenhead Park v Warrington | Park Drive, Birkenhead | Results |
| 04 Sep 2010 | | Brooklands v Congleton | Brooklands Sports Club, Sale | Results |
| 04 Sep 2010 | | Sale v Bredbury St Marks | Rookwood, Sale | Results |
| 04 Sep 2010 | | Ashton-on-Mersey v Marple | The Beets, Sale | Results |
| 04 Sep 2010 | | Timperley v Mobberley | Stockport Road, Timperley | Results |
| 04 Sep 2010 | | Tattenhall v Stockport Georgians | Flacca Field, Tattenhall | Results |
| 11 Sep 2010 | | Warrington v Congleton | Walton Lea Road, Warrington | Results |
| 11 Sep 2010 | | Mobberley v Ashton-on-Mersey | Church Lane, Mobberley | Results |
| 11 Sep 2010 | | Stockport Georgians v Timperley | Cromley Road, Woodsmoor | Results |
| 11 Sep 2010 | | Tattenhall v Brooklands | Flacca Field, Tattenhall | Results |
| 11 Sep 2010 | | Marple v Sale | Bowden Lane, Marple | Results |
| 11 Sep 2010 | | Bredbury St Marks v Birkenhead Park | Hillside Road, Woodley | Results |
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