| 22 Apr 2010 | North Division | Marylebone Cricket Club Young Cricketers v Warwickshire Second XI | London Road, High Wycombe | Results |
| 20 Apr 2010 | North Division | Nottinghamshire Second XI v Glamorgan Second XI | Nottinghamshire Sports Ground, Nottingham | Results |
| 26 Apr 2010 | South Division | Hampshire Second XI v Gloucestershire Second XI | Utilita Bowl, Southampton | Results |
| 26 Apr 2010 | South Division | Surrey Second XI v Somerset Second XI | The Kia Oval, Kennington | Results |
| 27 Apr 2010 | North Division | Nottinghamshire Second XI v Yorkshire Second XI | Nottinghamshire Sports Ground, Nottingham | Results |
| 03 May 2010 | South Division | Northamptonshire Second XI v Hampshire Second XI | Campbell Park, Milton Keynes | Results |
| 04 May 2010 | North Division | Glamorgan Second XI v Leicestershire Second XI | Sophia Gardens, Cardiff | Results |
| 04 May 2010 | South Division | Essex Second XI v Kent Second XI | Garon Park, Southend-on-Sea | Results |
| 04 May 2010 | North Division | Derbyshire Second XI v Yorkshire Second XI | Racecourse Ground, Derby | Results |
| 04 May 2010 | South Division | Gloucestershire Second XI v Surrey Second XI | Seat Unique Stadium, Bristol | Results |
| 10 May 2010 | South Division | Somerset Second XI v Middlesex Second XI | Taunton Vale Sports Club Ground, Taunton | Results |
| 10 May 2010 | South Division | Kent Second XI v Gloucestershire Second XI | The Kent County Cricket Ground, Beckenham | Results |
| 11 May 2010 | North Division | Nottinghamshire Second XI v Marylebone Cricket Club Young Cricketers | Caythorpe Road, Caythorpe | Results |
| 14 May 2010 | North Division | Durham Second XI v Lancashire Second XI | Seat Unique Riverside Ground, Chester-le-Street | Results |
| 17 May 2010 | South Division | Gloucestershire Second XI v Northamptonshire Second XI | Seat Unique Stadium, Bristol | Results |
| 17 May 2010 | South Division | Hampshire Second XI v Essex Second XI | Utilita Bowl (Nursery), Southampton | Results |
| 17 May 2010 | North Division | Yorkshire Second XI v Leicestershire Second XI | Headingley, Leeds | Results |
| 18 May 2010 | South Division | Surrey Second XI v Sussex Second XI | The Ridge, Purley | Results |
| 18 May 2010 | North Division | Nottinghamshire Second XI v Lancashire Second XI | Nottinghamshire Sports Ground, Nottingham | Results |
| 18 May 2010 | North Division | Glamorgan Second XI v Marylebone Cricket Club Young Cricketers | Lower Mill Street, Usk | Results |
| 25 May 2010 | North Division | Worcestershire Second XI v Nottinghamshire Second XI | Main Road, Ombersley | Results |
| 25 May 2010 | North Division | Lancashire Second XI v Warwickshire Second XI | Stanley Park, Blackpool | Results |
| 25 May 2010 | North Division | Glamorgan Second XI v Derbyshire Second XI | Sophia Gardens, Cardiff | Results |
| 25 May 2010 | South Division | Somerset Second XI v Hampshire Second XI | Taunton Vale Sports Club Ground, Taunton | Results |
| 01 Jun 2010 | South Division | Gloucestershire Second XI v Essex Second XI | Seat Unique Stadium, Bristol | Results |
| 01 Jun 2010 | South Division | Northamptonshire Second XI v Middlesex Second XI | County Ground, Northampton | Results |
| 01 Jun 2010 | South Division | Somerset Second XI v Kent Second XI | Taunton Vale Sports Club Ground, Taunton | Results |
| 02 Jun 2010 | South Division | Minor Counties v Northamptonshire Second XI | Marlins, Long Marston | Results |
| 04 Jun 2010 | South Division | Middlesex Second XI v Surrey Second XI | Brunton Memorial Ground, Radlett | Results |
| 08 Jun 2010 | North Division | Worcestershire Second XI v Marylebone Cricket Club Young Cricketers | Chester Road North, Kidderminster | Results |
| 08 Jun 2010 | North Division | Derbyshire Second XI v Warwickshire Second XI | Deer Park, Dunstall | Results |
| 09 Jun 2010 | South Division | Hampshire Second XI v Surrey Second XI | Utilita Bowl, Southampton | Results |
| 15 Jun 2010 | North Division | Durham Second XI v Glamorgan Second XI | Feethams Cricket Ground, Darlington | Results |
| 15 Jun 2010 | North Division | Marylebone Cricket Club Young Cricketers v Leicestershire Second XI | Brunton Memorial Ground, Radlett | Results |
| 15 Jun 2010 | South Division | Somerset Second XI v Gloucestershire Second XI | Taunton Vale Sports Club Ground, Taunton | Results |
| 17 Jun 2010 | South Division | Essex Second XI v Minor Counties | The Toby Howe Cricket Ground, Billericay | Results |
| 17 Jun 2010 | South Division | Sussex Second XI v Hampshire Second XI | Cricket Field Road, Horsham | Results |
| 22 Jun 2010 | South Division | Northamptonshire Second XI v Sussex Second XI | Wellingborough School Ground, Wellingborough | Results |
| 24 Jun 2010 | South Division | Minor Counties v Somerset Second XI | The Fortfield, Sidmouth | Results |
| 25 Jun 2010 | South Division | Middlesex Second XI v Essex Second XI | Brunton Memorial Ground, Radlett | Results |
| 28 Jun 2010 | North Division | Lancashire Second XI v Leicestershire Second XI | Centre Vale, Todmorden | Results |
| 28 Jun 2010 | North Division | Worcestershire Second XI v Glamorgan Second XI | Chester Road North, Kidderminster | Results |
| 28 Jun 2010 | North Division | Yorkshire Second XI v Warwickshire Second XI | Clifton Park, York | Results |
| 28 Jun 2010 | South Division | Middlesex Second XI v Gloucestershire Second XI | Brunton Memorial Ground, Radlett | Results |
| 28 Jun 2010 | South Division | Northamptonshire Second XI v Somerset Second XI | Campbell Park, Milton Keynes | Results |
| 28 Jun 2010 | South Division | Surrey Second XI v Minor Counties | Peaches Close, Cheam | Results |
| 28 Jun 2010 | North Division | Marylebone Cricket Club Young Cricketers v Durham Second XI | Uxbridge Cricket Club Ground, Uxbridge | Results |
| 05 Jul 2010 | North Division | Marylebone Cricket Club Young Cricketers v Yorkshire Second XI | Brunton Memorial Ground, Radlett | Results |
| 05 Jul 2010 | North Division | Leicestershire Second XI v Durham Second XI | Upper Field, Uppingham School | Results |
| 06 Jul 2010 | South Division | Surrey Second XI v Northamptonshire Second XI | Whitgift School, Croydon | Results |
| 06 Jul 2010 | North Division | Derbyshire Second XI v Worcestershire Second XI | Highfield, Leek | Results |
| 08 Jul 2010 | South Division | Minor Counties v Sussex Second XI | Enborne Lodge, Newbury | Results |
| 09 Jul 2010 | South Division | Hampshire Second XI v Minor Counties | Utilita Bowl, Southampton | Results |
| 13 Jul 2010 | South Division | Kent Second XI v Middlesex Second XI | Birley's Field, Canterbury | Results |
| 12 Jul 2010 | North Division | Warwickshire Second XI v Worcestershire Second XI | King Edward's School Birmingham Ground, Birmingham | Results |
| 15 Jul 2010 | South Division | Gloucestershire Second XI v Minor Counties | Clifton College Close Ground, Clifton | Results |
| 16 Jul 2010 | North Division | Nottinghamshire Second XI v Derbyshire Second XI | Trent College Ground, Long Eaton | Results |
| 16 Jul 2010 | South Division | Essex Second XI v Sussex Second XI | Hare Field, Coggeshall | Results |
| 19 Jul 2010 | South Division | Kent Second XI v Hampshire Second XI | Spitfire Ground, St Lawrence, Canterbury | Results |
| 20 Jul 2010 | North Division | Lancashire Second XI v Marylebone Cricket Club Young Cricketers | The Crimble Ground, Heywood | Results |
| 20 Jul 2010 | North Division | Leicestershire Second XI v Nottinghamshire Second XI | Uptonsteel County Ground, Leicester | Results |
| 20 Jul 2010 | North Division | Warwickshire Second XI v Glamorgan Second XI | Kings Heath Cricket Club Ground, Kings Heath | Results |
| 20 Jul 2010 | North Division | Derbyshire Second XI v Durham Second XI | Raynesway, Alvaston | Results |
| 20 Jul 2010 | South Division | Sussex Second XI v Gloucestershire Second XI | Cricket Field Road, Horsham | Results |
| 26 Jul 2010 | North Division | Yorkshire Second XI v Worcestershire Second XI | Wagon Lane, Bingley | Results |
| 27 Jul 2010 | North Division | Marylebone Cricket Club Young Cricketers v Derbyshire Second XI | Brunton Memorial Ground, Radlett | Results |
| 27 Jul 2010 | North Division | Warwickshire Second XI v Durham Second XI | Station Road, Dorridge | Results |
| 27 Jul 2010 | North Division | Glamorgan Second XI v Lancashire Second XI | Panteg House, Griffithstown | Results |
| 29 Jul 2010 | South Division | Minor Counties v Middlesex Second XI | Manor Park, Horsford | Results |
| 30 Jul 2010 | South Division | Essex Second XI v Northamptonshire Second XI | The Toby Howe Cricket Ground, Billericay | Results |
| 30 Jul 2010 | South Division | Minor Counties v Kent Second XI | Manor Park, Horsford | Results |
| 02 Aug 2010 | North Division | Derbyshire Second XI v Leicestershire Second XI | Racecourse Ground, Derby | Results |
| 02 Aug 2010 | North Division | Lancashire Second XI v Yorkshire Second XI | Moor Park, Great Crosby | Results |
| 03 Aug 2010 | North Division | Durham Second XI v Worcestershire Second XI | Roseworth Terrace, Gosforth | Results |
| 03 Aug 2010 | South Division | Sussex Second XI v Kent Second XI | New County Ground, Hove | Results |
| 05 Aug 2010 | South Division | Surrey Second XI v Essex Second XI | The Kia Oval, Kennington | Results |
| 09 Aug 2010 | South Division | Middlesex Second XI v Hampshire Second XI | Brunton Memorial Ground, Radlett | Results |
| 09 Aug 2010 | North Division | Worcestershire Second XI v Lancashire Second XI | Main Road, Ombersley | Results |
| 09 Aug 2010 | South Division | Sussex Second XI v Somerset Second XI | The Pavilion, Birdham | Results |
| 10 Aug 2010 | North Division | Leicestershire Second XI v Warwickshire Second XI | Uptonsteel County Ground, Leicester | Results |
| 10 Aug 2010 | North Division | Durham Second XI v Nottinghamshire Second XI | Acklam Park, Middlesbrough | Results |
| 16 Aug 2010 | North Division | Lancashire Second XI v Derbyshire Second XI | Emirates Old Trafford, Manchester | Results |
| 16 Aug 2010 | South Division | Northamptonshire Second XI v Kent Second XI | Bedford School Ground, Bedford | Results |
| 16 Aug 2010 | North Division | Yorkshire Second XI v Durham Second XI | Headingley, Leeds | Results |
| 17 Aug 2010 | South Division | Essex Second XI v Somerset Second XI | The Cloud County Ground, Chelmsford | Results |
| 17 Aug 2010 | South Division | Sussex Second XI v Middlesex Second XI | New County Ground, Hove | Results |
| 17 Aug 2010 | North Division | Warwickshire Second XI v Nottinghamshire Second XI | Meeting House Lane, Balsall Common | Results |
| 17 Aug 2010 | North Division | Leicestershire Second XI v Worcestershire Second XI | Uptonsteel County Ground, Leicester | Results |
| 23 Aug 2010 | North Division | Glamorgan Second XI v Yorkshire Second XI | Sophia Gardens, Cardiff | Results |
| 24 Aug 2010 | South Division | Kent Second XI v Surrey Second XI | Spitfire Ground, St Lawrence, Canterbury | Results |
| 30 Aug 2010 | Semi-Final | Middlesex Second XI v Lancashire Second XI | Brunton Memorial Ground, Radlett | Results |
| 31 Aug 2010 | Semi-Final | Nottinghamshire Second XI v Essex Second XI | Trent Bridge, Nottingham | Results |
| 13 Sep 2010 | Final | Essex Second XI v Lancashire Second XI | The Cloud County Ground, Chelmsford | Results |
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