| 13 Apr 2010 | South Division | Northamptonshire Second XI v Middlesex Second XI | County Ground, Northampton | Results |
| 19 Apr 2010 | North Division | Marylebone Cricket Club Young Cricketers v Warwickshire Second XI | London Road, High Wycombe | Results |
| 21 Apr 2010 | South Division | Middlesex Second XI v Surrey Second XI | Brunton Memorial Ground, Radlett | Results |
| 21 Apr 2010 | North Division | Nottinghamshire Second XI v Glamorgan Second XI | Nottinghamshire Sports Ground, Nottingham | Results |
| 27 Apr 2010 | South Division | Hampshire Second XI v Gloucestershire Second XI | Utilita Bowl (Nursery), Southampton | Results |
| 27 Apr 2010 | South Division | Surrey Second XI v Somerset Second XI | The Kia Oval, Kennington | Results |
| 28 Apr 2010 | North Division | Nottinghamshire Second XI v Yorkshire Second XI | Nottinghamshire Sports Ground, Nottingham | Results |
| 04 May 2010 | South Division | Northamptonshire Second XI v Hampshire Second XI | Stowe School Ground, Stowe | Results |
| 05 May 2010 | South Division | Gloucestershire Second XI v Surrey Second XI | Seat Unique Stadium, Bristol | Results |
| 05 May 2010 | North Division | Glamorgan Second XI v Leicestershire Second XI | Pen-y-Pound, Abergavenny | Results |
| 05 May 2010 | North Division | Derbyshire Second XI v Yorkshire Second XI | Racecourse Ground, Derby | Results |
| 12 May 2010 | South Division | Surrey Second XI v Essex Second XI | Woodbridge Road, Guildford | Results |
| 11 May 2010 | South Division | Somerset Second XI v Middlesex Second XI | Taunton Vale Sports Club Ground, Taunton | Results |
| 11 May 2010 | South Division | Kent Second XI v Gloucestershire Second XI | The Kent County Cricket Ground, Beckenham | Results |
| 12 May 2010 | North Division | Nottinghamshire Second XI v Marylebone Cricket Club Young Cricketers | Nottinghamshire Sports Ground, Nottingham | Results |
| 11 May 2010 | North Division | Durham Second XI v Lancashire Second XI | Seat Unique Riverside Ground, Chester-le-Street | Results |
| 18 May 2010 | South Division | Gloucestershire Second XI v Northamptonshire Second XI | Seat Unique Stadium, Bristol | Results |
| 18 May 2010 | North Division | Yorkshire Second XI v Leicestershire Second XI | Shaw Lane, Barnsley | Results |
| 18 May 2010 | South Division | Hampshire Second XI v Essex Second XI | Utilita Bowl, Southampton | Results |
| 19 May 2010 | North Division | Nottinghamshire Second XI v Lancashire Second XI | Sports Ground, Cleethorpes | Results |
| 19 May 2010 | North Division | Glamorgan Second XI v Marylebone Cricket Club Young Cricketers | Lower Mill Street, Usk | Results |
| 19 May 2010 | South Division | Surrey Second XI v Sussex Second XI | The Ridge, Purley | Results |
| 26 May 2010 | South Division | Somerset Second XI v Hampshire Second XI | Taunton Vale Sports Club Ground, Taunton | Results |
| 26 May 2010 | North Division | Lancashire Second XI v Warwickshire Second XI | Stanley Park, Blackpool | Results |
| 26 May 2010 | North Division | Worcestershire Second XI v Nottinghamshire Second XI | Main Road, Ombersley | Results |
| 26 May 2010 | North Division | Glamorgan Second XI v Derbyshire Second XI | Pontarddulais Park, Pontarddulais | Results |
| 02 Jun 2010 | South Division | Gloucestershire Second XI v Essex Second XI | Seat Unique Stadium, Bristol | Results |
| 02 Jun 2010 | South Division | Somerset Second XI v Kent Second XI | Taunton Vale Sports Club Ground, Taunton | Results |
| 02 Jun 2010 | South Division | Sussex Second XI v Hampshire Second XI | The Pavilion, Birdham | Results |
| 09 Jun 2010 | North Division | Worcestershire Second XI v Marylebone Cricket Club Young Cricketers | Chester Road North, Kidderminster | Results |
| 09 Jun 2010 | South Division | Essex Second XI v Kent Second XI | Garon Park, Southend-on-Sea | Results |
| 09 Jun 2010 | North Division | Derbyshire Second XI v Warwickshire Second XI | Deer Park, Dunstall | Results |
| 16 Jun 2010 | South Division | Somerset Second XI v Gloucestershire Second XI | Taunton Vale Sports Club Ground, Taunton | Results |
| 16 Jun 2010 | North Division | Marylebone Cricket Club Young Cricketers v Leicestershire Second XI | Brunton Memorial Ground, Radlett | Results |
| 16 Jun 2010 | North Division | Durham Second XI v Glamorgan Second XI | Feethams Cricket Ground, Darlington | Results |
| 23 Jun 2010 | South Division | Northamptonshire Second XI v Sussex Second XI | Dolben Cricket Ground, Finedon | Results |
| 29 Jun 2010 | North Division | Yorkshire Second XI v Warwickshire Second XI | Clifton Park, York | Results |
| 29 Jun 2010 | South Division | Northamptonshire Second XI v Somerset Second XI | Campbell Park, Milton Keynes | Results |
| 29 Jun 2010 | North Division | Worcestershire Second XI v Glamorgan Second XI | Chester Road North, Kidderminster | Results |
| 29 Jun 2010 | North Division | Marylebone Cricket Club Young Cricketers v Durham Second XI | Uxbridge Cricket Club Ground, Uxbridge | Results |
| 29 Jun 2010 | North Division | Lancashire Second XI v Leicestershire Second XI | Centre Vale, Todmorden | Results |
| 29 Jun 2010 | South Division | Middlesex Second XI v Gloucestershire Second XI | Brunton Memorial Ground, Radlett | Results |
| 30 Jun 2010 | South Division | Marylebone Cricket Club Universities v Sussex Second XI | Cricket Field Road, Horsham | Results |
| 06 Jul 2010 | North Division | Leicestershire Second XI v Durham Second XI | Lime Kilns Ground, Oakham | Results |
| 06 Jul 2010 | North Division | Marylebone Cricket Club Young Cricketers v Yorkshire Second XI | Brunton Memorial Ground, Radlett | Results |
| 07 Jul 2010 | North Division | Derbyshire Second XI v Worcestershire Second XI | Christchurch Meadows, Belper | Results |
| 07 Jul 2010 | South Division | Essex Second XI v Marylebone Cricket Club Universities | The Toby Howe Cricket Ground, Billericay | Results |
| 07 Jul 2010 | South Division | Surrey Second XI v Northamptonshire Second XI | Whitgift School, Croydon | Results |
| 13 Jul 2010 | South Division | Hampshire Second XI v Marylebone Cricket Club Universities | Utilita Bowl, Southampton | Results |
| 13 Jul 2010 | South Division | Essex Second XI v Sussex Second XI | Hare Field, Coggeshall | Results |
| 14 Jul 2010 | South Division | Kent Second XI v Middlesex Second XI | Birley's Field, Canterbury | Results |
| 13 Jul 2010 | North Division | Worcestershire Second XI v Warwickshire Second XI | Cherry Hill Road, Barnt Green | Results |
| 20 Jul 2010 | South Division | Kent Second XI v Hampshire Second XI | Spitfire Ground, St Lawrence, Canterbury | Results |
| 21 Jul 2010 | South Division | Sussex Second XI v Gloucestershire Second XI | Cricket Field Road, Horsham | Results |
| 21 Jul 2010 | South Division | Middlesex Second XI v Essex Second XI | Brunton Memorial Ground, Radlett | Results |
| 21 Jul 2010 | North Division | Warwickshire Second XI v Glamorgan Second XI | Swans Nest Lane, Stratford-upon-Avon | Results |
| 21 Jul 2010 | South Division | Marylebone Cricket Club Universities v Northamptonshire Second XI | Weetwood Playing Fields, Leeds | Results |
| 21 Jul 2010 | North Division | Derbyshire Second XI v Durham Second XI | The Copper Yard, Denby Village | Results |
| 21 Jul 2010 | North Division | Lancashire Second XI v Marylebone Cricket Club Young Cricketers | Church Road, Lytham St Annes | Results |
| 21 Jul 2010 | North Division | Leicestershire Second XI v Nottinghamshire Second XI | Fairfield Road, Market Harborough | Results |
| 27 Jul 2010 | North Division | Yorkshire Second XI v Worcestershire Second XI | Centre Vale, Todmorden | Results |
| 27 Jul 2010 | South Division | Essex Second XI v Northamptonshire Second XI | The Toby Howe Cricket Ground, Billericay | Results |
| 28 Jul 2010 | South Division | Surrey Second XI v Marylebone Cricket Club Universities | Jubilee, Cranleigh School | Results |
| 28 Jul 2010 | North Division | Glamorgan Second XI v Lancashire Second XI | Panteg House, Griffithstown | Results |
| 28 Jul 2010 | North Division | Marylebone Cricket Club Young Cricketers v Derbyshire Second XI | Brunton Memorial Ground, Radlett | Results |
| 28 Jul 2010 | North Division | Warwickshire Second XI v Durham Second XI | Scorers, Shirley | Results |
| 02 Aug 2010 | South Division | Hampshire Second XI v Surrey Second XI | Utilita Bowl, Southampton | Results |
| 03 Aug 2010 | North Division | Derbyshire Second XI v Leicestershire Second XI | Racecourse Ground, Derby | Results |
| 03 Aug 2010 | North Division | Lancashire Second XI v Yorkshire Second XI | Moor Park, Great Crosby | Results |
| 04 Aug 2010 | South Division | Marylebone Cricket Club Universities v Middlesex Second XI | FP Fenner's Ground, Cambridge | Results |
| 04 Aug 2010 | South Division | Sussex Second XI v Kent Second XI | New County Ground, Hove | Results |
| 04 Aug 2010 | North Division | Durham Second XI v Worcestershire Second XI | Roseworth Terrace, Gosforth | Results |
| 10 Aug 2010 | South Division | Sussex Second XI v Somerset Second XI | The Pavilion, Birdham | Results |
| 10 Aug 2010 | North Division | Worcestershire Second XI v Lancashire Second XI | Main Road, Ombersley | Results |
| 10 Aug 2010 | South Division | Middlesex Second XI v Hampshire Second XI | Brunton Memorial Ground, Radlett | Results |
| 11 Aug 2010 | North Division | Durham Second XI v Nottinghamshire Second XI | Acklam Park, Middlesbrough | Results |
| 11 Aug 2010 | North Division | Leicestershire Second XI v Warwickshire Second XI | Kibworth Cricket Club New Ground, Kibworth | Results |
| 11 Aug 2010 | South Division | Marylebone Cricket Club Universities v Kent Second XI | FP Fenner's Ground, Cambridge | Results |
| 17 Aug 2010 | South Division | Northamptonshire Second XI v Kent Second XI | Campbell Park, Milton Keynes | Results |
| 17 Aug 2010 | North Division | Lancashire Second XI v Derbyshire Second XI | Emirates Old Trafford, Manchester | Results |
| 17 Aug 2010 | South Division | Gloucestershire Second XI v Marylebone Cricket Club Universities | Seat Unique Stadium, Bristol | Results |
| 17 Aug 2010 | North Division | Yorkshire Second XI v Durham Second XI | Headingley, Leeds | Results |
| 18 Aug 2010 | South Division | Essex Second XI v Somerset Second XI | The Cloud County Ground, Chelmsford | Results |
| 18 Aug 2010 | South Division | Sussex Second XI v Middlesex Second XI | New County Ground, Hove | Results |
| 18 Aug 2010 | North Division | Leicestershire Second XI v Worcestershire Second XI | Fairfield Road, Market Harborough | Results |
| 18 Aug 2010 | North Division | Warwickshire Second XI v Nottinghamshire Second XI | Glasshouse Park, Kenilworth | Results |
| 24 Aug 2010 | South Division | Somerset Second XI v Marylebone Cricket Club Universities | Millfield School, Street | Results |
| 24 Aug 2010 | North Division | Glamorgan Second XI v Yorkshire Second XI | Sophia Gardens, Cardiff | Results |
| 25 Aug 2010 | South Division | Kent Second XI v Surrey Second XI | Spitfire Ground, St Lawrence, Canterbury | Results |
| 25 Aug 2010 | North Division | Nottinghamshire Second XI v Derbyshire Second XI | Nottinghamshire Sports Ground, Nottingham | Results |
| 07 Sep 2010 | Final | Surrey Second XI v Warwickshire Second XI | Sir Paul Getty's Ground, Wormsley | Results |
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